Chemotherapy-type anticancer drug inhalation powder preparation and preparing method and application thereof

An anticancer drug and powder technology is applied in the field of inhaled dosage forms of inhaled chemotherapy anticancer drugs, which can solve the problems of insufficient active ingredients and strong toxic and side effects, and achieve the effects of reducing high blood pressure, complete absorption, and reducing toxicity.

Inactive Publication Date: 2017-05-03
ZHOUSHAN SANHE BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] For cancers of the respiratory system, such as lung cancer, oral cancer, laryngeal cancer, nasopharyngeal cancer, etc., in order to solve the problems

Method used

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  • Chemotherapy-type anticancer drug inhalation powder preparation and preparing method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1 Chemotherapy anticancer drug inhalation powder formulation

[0038] The preparation method is as follows:

[0039] 1) Active ingredient powder

[0040] 2g paclitaxel (or docetaxel, cabazitaxel) was dissolved in 40g absolute ethanol.

[0041] Mix 4.5g of Omega-3 fatty acid sodium salt, 0.4g of phytic acid, 0.1g of poloxamer, 0.1g of vitamin E and 40g of water.

[0042] The above-mentioned paclitaxel solution and Omega-3 solution are thoroughly mixed, the powder is made by freeze-drying method, and the powder is pulverized with a fluid energy mill, and the powder with a particle size of 2-3 μm is selected.

[0043] 2) Carrier powder

[0044] Mix 20 g of lactose, 0.3 g of poloxamer and 1 g of magnesium stearate thoroughly, prepare powder by spray drying method, grind with a fluid energy mill, sieving, and take powder with a particle size of 20-40 μm.

[0045] 3) Mix the above-mentioned active ingredient powder and carrier powder uniformly. This formula is 1,000 unit doses. Ea...

Embodiment 2

[0047] Example 2 Chemotherapy anticancer drug inhalation powder formulation

[0048] The preparation method is as follows:

[0049] 1) Active ingredient powder

[0050] Combine 2g paclitaxel (or docetaxel, cabazitaxel), 4.5g Omega-3 fatty acids (including ethyl ester, or triglycerides, or free acid form), 0.4g phytic acid, 0.4g absolute ethanol, 0.1g poise Loxamer and 0.1 g of vitamin E are thoroughly mixed and dissolved, and the powder is made by spray drying method, and the powder is pulverized with a fluid energy mill, and the powder with a particle size of 2-3 μm is selected.

[0051] 2) Carrier powder

[0052] Mix 20 g of lactose, 0.3 g of poloxamer and 1 g of magnesium stearate thoroughly, prepare powder by spray drying method, grind with a fluid energy mill, sieving, and take powder with a particle size of 20-30 μm.

[0053] 3) Mix the above-mentioned active ingredient powder and carrier powder uniformly. This formula is 1,000 unit doses. Each unit of medicine is packed into a ca...

Embodiment 3

[0055] Example 3 Chemotherapy anticancer drug inhalation powder formulation

[0056] The preparation method is as follows:

[0057] 1) Active ingredient powder

[0058] Mix 2g of paclitaxel (or docetaxel, cabazitaxel), 4.5g of Omega-3 fatty acid sodium salt, 0.4g of phytic acid, 0.4g of absolute ethanol, and 0.1g of vitamin E to dissolve it, and spray-dry it to make a powder. The fluid energy mill grinds to obtain fine powder, and the powder with a particle size of 1-3μm is selected.

[0059] 2) Carrier powder 1

[0060] Mix 2 g of lactose, 0.03 g of poloxamer and 0.1 g of magnesium stearate thoroughly, spray-dry the powder into powder, and grind it with a fluid energy mill to obtain a powder with a particle size of 4-6 μm.

[0061] 3) Carrier powder 2

[0062] Mix 20 g of lactose, 0.3 g of poloxamer, 1 g of magnesium stearate and 1 g of anhydrous ethanol, and use the spray drying method to prepare a powder, which is ground with a fluid energy mill to obtain a powder with a particle size...

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Abstract

The invention relates to a chemotherapy-type anticancer drug inhalation powder preparation and a preparing method and application thereof. According to the technical scheme, the chemotherapy-type anticancer drug inhalation powder preparation is obtained by mixing effective constituent powder with the grain diameter being 0.4-5 microns or 10-100 microns and carrier powder with the grain diameter being 10-100 microns. The effective constituent powder comprises a chemotherapy-type anticancer drug and Omega-3 fatty acid. The carrier powder comprises saccharides, an emulsifier and magnesium stearate. The application effect of the preparation in treatment of respiratory system cancers like a laryngeal cancer, a lung cancer and other tumor diseases is obvious. The inhalant form toxicity is small, the application is convenient, and the anticancer treatment effect has advantages compared with other dosage forms.

Description

Technical field [0001] The invention belongs to the field of chemotherapeutic anticancer drug preparations, and particularly relates to an inhaled dosage form of an inhaled chemotherapeutic anticancer drug, which is used for the treatment of respiratory system cancer by a topical drug method to achieve the effects of increasing curative effect and reducing toxicity. Background technique [0002] Chemotherapy anticancer drugs have long been used to treat cancer. Such drugs include (1) alkylating agents: alkylating agents directly act on DNA to prevent cancer cells from regenerating; (2) antimetabolites: antimetabolites that interfere with the synthesis of DNA and RNA. Such drugs are mainly used to treat chronic diseases. Leukemia, breast cancer, ovarian cancer, gastric cancer and colorectal cancer; (3) Anti-tumor antibiotics: interfere with DNA by inhibiting the action of enzymes and mitosis or changing cell membranes. Such drugs are widely used in the treatment of cancer; (4) Pl...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K9/72A61K31/337A61K31/202A61K31/557A61P35/00
Inventor 蔺新力
Owner ZHOUSHAN SANHE BIOTECH CO LTD
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