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Water-soluble glabridin microcapsule and preparation method thereof

A glabridin, water-soluble technology, applied in pharmaceutical formulations, cosmetic preparations, cosmetic preparations, etc., can solve problems such as poor stability of water-soluble glabridin capsules, and achieve protection of structural integrity and stability, spherical shape The effect of improving the active utilization rate

Inactive Publication Date: 2017-05-10
SHANGHAI INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Aiming at the above-mentioned technical problems in the prior art, the invention provides a kind of water-soluble glabridin microcapsules and its preparation method, and the described water-soluble glabridin microcapsules and its preparation method will solve the problems in the prior art. The technical problem of poor stability of the water-soluble glabridin capsules in high tide environment

Method used

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  • Water-soluble glabridin microcapsule and preparation method thereof
  • Water-soluble glabridin microcapsule and preparation method thereof
  • Water-soluble glabridin microcapsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Based on 1000g of formulation raw materials, take 1g of water-soluble glabridin, 10g of lipophilic emulsifier, 10g of chitosan, 10g of glacial acetic acid, 10g of water, 0.05g of glutaraldehyde, and 958.95g of liquid oil.

[0047] Described lipophilic emulsifier is ceteareth-6;

[0048] The liquid oil is caprylic capric triglyceride;

[0049] The steps of preparation method are as follows:

[0050] 1) glacial acetic acid is dissolved in water to make acetic acid solution;

[0051]2) Chitosan is added to the acetic acid solution prepared in step 1), heated at 30° C. to dissolve completely, and the chitosan acetic acid solution is obtained after standing to remove air bubbles;

[0052] 3) adding water-soluble glabridin into the solution prepared in step 2), and stirring evenly at 25°C to obtain the first solution;

[0053] 4) Add the lipophilic emulsifier into the liquid oil, and stir evenly in a constant temperature water bath at 25°C to obtain the second solution;

...

Embodiment 1

[0058] Embodiment 1 comparative example:

[0059] That is, a 1% water-soluble glabridin aqueous solution is prepared.

[0060] The water-soluble glabridin microcapsules obtained in the above-mentioned Example 1 and the obtained comparative example of Example 1 contain 1% water-soluble glabridin aqueous solution permeability data determination, and the results are shown in the following table:

[0061]

Embodiment 2

[0063] Based on 1000g of formula raw materials, take 50g of water-soluble glabridin, 300g of lipophilic emulsifier, 100g of chitosan, 100g of glacial acetic acid, 300g of water, 1g of glutaraldehyde, and 149g of liquid oil.

[0064] Described lipophilic emulsifier is ceteareth-25;

[0065] Described liquid grease is isopropyl myristate;

[0066] The steps of preparation method are as follows:

[0067] 1) glacial acetic acid is dissolved in water to make acetic acid solution;

[0068] 2) Chitosan is added to the acetic acid solution prepared in step 1), heated at 60° C. to completely dissolve, and the chitosan acetic acid solution is obtained after standing to remove air bubbles;

[0069] 3) adding water-soluble glabridin to the solution prepared in step 2), stirring at 50°C to obtain the first solution;

[0070] 4) Add the lipophilic emulsifier into the liquid oil, and stir evenly in a constant temperature water bath at 60°C to obtain the second solution;

[0071] 5) Heati...

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Abstract

The invention relates to a water-soluble glabridin microcapsule which is prepared from the following materials in mass percent concentration: 0.1 to 5% of water-soluble glabridin, 1 to 30% of lipophilic emulsifier, 1 to 10% of chitosan, 1 to 10% of glacial acetic acid, 1 to 30% of water, 0.005 to 0.1% of glutaric dialdehyde and the balance of liquid-state grease. The invention further provides a preparation method of the microcapsule. The preparation method comprises the steps of heating and dissolving the water-soluble glabridin, the chitosan and the glacial acetic acid into the water to obtain a water-phase component; mixing, heating and evenly scattering the lipophilic emulsifier and the liquid-state grease to obtain an oil-phase component; adding the water-phase component into the oil-phase component in stirring to obtain lactescence; adding the glutaric dialdehyde into the lactescence for curing, and sequentially performing centrifuging, washing with ethanol and petroleum ether, acetone scattering and air drying to obtain the water-soluble glabridin microcapsule. The water-soluble glabridin microcapsule of the invention has the advantages of good biocompatibility, good safety and a good slow-release effect, thus improving absorption and permeation on skin.

Description

technical field [0001] The invention belongs to the field of cosmetics and relates to microcapsules, in particular to a water-soluble glabridin microcapsule and a preparation method thereof. Background technique [0002] Glabridin is a natural high-efficiency whitening factor. Its whitening effect is 232 times higher than the common ingredient vitamin C. It is known as "whitening gold". It has antibacterial, anti-oxidant, and prevents inflammation, pigmentation and skin It can cooperate with the skin's self-repair process, enhance the whitening effect, and deeply moisturize the skin after sun exposure. However, glabridin is insoluble in water and has poor permeability. Generally, it is modified into water-soluble by introducing functional groups to expand its application range in the field of cosmetics. However, water-soluble glabridin has poor stability in a high tide environment, which affects water-soluble light. Glycyrrhizin is widely used in the field of cosmetics. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/11A61K8/49A61K8/73A61K8/37A61K8/36A61K8/33A61Q19/08A61Q19/02A61Q19/00A61Q17/00
CPCA61K8/498A61K8/11A61K8/33A61K8/36A61K8/37A61K8/375A61K8/736A61K2800/10A61K2800/412A61Q17/005A61Q19/00A61Q19/02A61Q19/08
Inventor 张婉萍赵晓伟张倩洁朱海洋
Owner SHANGHAI INST OF TECH
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