Method for preparing 3-(2-aminopropyl)phenol
A technology of aminopropyl and phenol, which is applied in the field of preparation of 3-phenol, can solve the problems of complex post-processing operation, unfavorable industrial production, and poor production safety, so as to simplify the reaction process and post-processing process, reduce production risks, reduce The effect of production costs
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[0032] Example 1
[0033] The first step: the synthesis of 1-(3-methoxyphenyl) isopropanol.
[0034] Slowly add a solution of m-methoxybromobenzene (481mmol, 90g) in tetrahydrofuran (400ml) dropwise to a solution of 1,2-dibromoethane (4ml) and magnesium chips (481mmol, 11.7g) in ether (400ml) The reaction mixture was stirred and refluxed until the magnesium chips were dissolved. Then propylene oxide (433 mmol, 25.15 g) was added to the reaction mixture at 30°C, and the reaction was reacted at this temperature for 20 minutes, and then the temperature was raised to room temperature and stirred for 1 hour. The reaction was quenched with aqueous ammonium chloride solution (600ml) and extracted with ether (2000ml). The organic layer was washed with water and brine successively, dried over sodium sulfate, spin-dried and passed through an elution column (eluent: petroleum ether / ethyl acetate = 4 / 1) 1-(3-methoxyphenyl) isopropanol (64.7 g, yield: 80.89%) was obtained as an oil.
[0035] A...
Example Embodiment
[0048] Example 2
[0049] The first step: the synthesis of 1-(3-methoxyphenyl) isopropanol.
[0050] Slowly add a solution of m-methoxybromobenzene (481mmol, 90g) in ether (400ml) dropwise to the solution of 1,2-dibromoethane (4ml) and magnesium chips (481mmol, 11.7g) in ether (400ml) The reaction mixture was stirred and refluxed until the magnesium chips were dissolved. Then propylene oxide (457 mmol, 26.5 g) was added to the reaction mixture at 30°C, and the reaction was allowed to react at this temperature for 20 minutes, and then the temperature was raised to room temperature and stirred for 1 hour. The reaction was quenched with aqueous ammonium chloride solution (600ml) and extracted with ether (2000ml). The organic layer was washed with water and brine successively, dried over sodium sulfate, spin-dried and passed through an elution column (eluent: petroleum ether / ethyl acetate = 4 / 1) 1-(3-methoxyphenyl)isopropanol (65.6g, yield: 82%) was obtained as an oil.
[0051] After ...
Example Embodiment
[0062] Example 3
[0063] The first step: the synthesis of 1-(3-methoxyphenyl) isopropanol.
[0064] Slowly add a solution of m-methoxybromobenzene (481mmol, 90g) in 1,2-dibromoethane (400ml) dropwise to 1,2-dibromoethane (4ml) and magnesium chips (481mmol, 11.7g) In the ether (400ml) solution, the reaction mixture was stirred and refluxed until the magnesium chips were dissolved. Then propylene oxide (409mmol, 23.8g) was added to the reaction mixture at 30°C, and the reaction was reacted at this temperature for 20 minutes, then the temperature was raised to room temperature and stirred for 1 hour. The reaction was quenched with aqueous ammonium chloride solution (600ml) and extracted with ether (2000ml). The organic layer was washed with water and brine successively, dried over sodium sulfate, spin-dried and passed through an elution column (eluent: petroleum ether / ethyl acetate = 4 / 1) 1-(3-methoxyphenyl)isopropanol (64.1 g, yield: 80.1%) was obtained as an oil.
[0065] After nu...
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