Preparation method of (Z)-2-(tert-methoxycarbonyl methoxyimino)-2-(2-aminothiazol-4-yl)acetic acid
A technology of cefixime side chain acid and cefixime ring-opening side chain acid, applied in the direction of organic chemistry, etc., can solve problems such as hidden dangers of production safety, increase process flow, increase production cost, etc. The effect of simple handling and lower production costs
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[0021] This embodiment relates to a method for preparing cefixime side chain acid, including the following steps:
[0022] Cefixime ring-opening side chain acid is prepared by laboratory synthesis reaction. Using tert-butyl acetoacetate as raw material, cefixime ring-opening side chain acid is synthesized through oximation, alkylation, and chloro-acid hydrolysis. The purity is greater than 92. %;
[0023] a. In a 500ml four-necked bottle, add 150g water and 100g cefixime ring-opening side chain acid successively, control the temperature at 15~20℃, and slowly add ammonium bicarbonate until the cefixime ring-opening side chain acid is dissolved, and then use Adjust the pH value of ammonium bicarbonate to 4.5±0.2, then add activated carbon for decolorization, stir at 15°C for 30 minutes, and filter to obtain the ammonium salt aqueous solution of cefixime ring-opening side chain acid; the amount of ammonium bicarbonate added in this step is 30.67g;
[0024] b. Add 34.6g of thiourea, 230...
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