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Bionic ligament and bionic ligament system

A ligament and bionic technology, applied in the field of biomedicine, can solve problems such as uncontrollable mechanical stability, foreign body rejection, and few joint points, and achieve good fixation and repair effects, good mechanical properties, and reduce mechanical loss.

Active Publication Date: 2017-05-31
MEDPRIN REGENERATIVE MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of these artificial ligaments are braided structures, resulting in too tight structure, non-degradable materials, poor biocompatibility, and it is difficult for new tissues to grow in or it is difficult to realize the anti-tension and anti-friction effect of wrapping materials.
And with long-term friction and stretching, the artificial ligament is prone to strain and fracture
Moreover, if no new ligament tissue is formed on the artificial ligament to replace the artificial ligament, the artificial ligament will eventually break, and the fibrous debris produced by the frictional strain of the artificial ligament will remain in the joint, causing obvious foreign body rejection, leading to severe slippage. meningitis, arthritis etc.
[0005] In addition, degradable and absorbable artificial ligaments are attracting more and more attention. For example, LC ligaments on the market can avoid the retention of foreign bodies and reduce rejection, but the biomechanical properties of degradable absorbing materials are different from those of tendons. The sharp decline is much faster than the formation of new tendons, which is not conducive to the repair of tendons and the maintenance of functions, and it is prone to fracture due to material fatigue two or three years after surgery
[0006] In addition, the existing artificial ligament products have a single material, it is difficult to simulate the complex anatomical structure of human ligaments, and it is impossible to achieve functional replacement to the greatest extent.
Due to the lack of joint points and difficult fusion with the existing artificial ligament and bone tunnel, it is easy to cause the ligament to detach from the bone tunnel
And the mechanical stability cannot be controlled, which makes it difficult to fuse the bone tunnel with the artificial ligament

Method used

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  • Bionic ligament and bionic ligament system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0096]

[0097] Use hexafluoroisopropanol to dissolve polylactic acid, configure an electrospinning solution with a mass concentration of 10%, add the electrospinning solution into the syringe, and connect the front tube of the micropump and the spinneret needle, set the spinning voltage to 25kV, and the solution The propulsion speed is 10mL / h, and the receiving distance is 30cm. After electrospinning, the obtained electrospun membrane was placed in a forced air drying oven at 50°C for 5 hours, then soaked in 75% alcohol for 1 hour, and then dried in a drying oven at 50°C overnight to obtain a polylactic acid nanofiber membrane.

[0098]

[0099] A fiber thread made of 45 (1 cluster) PET fiber filaments was selected, and the fiber thread was fixed on the polylactic acid nanofiber film by sewing to obtain a composite film. Wherein, one fiber thread is made of one cluster of PET fiber threads, four fiber threads are one fiber thread group, the fiber threads in the same fiber...

Embodiment 2

[0105]

[0106] Use hexafluoroisopropanol to dissolve polycaprolactone, prepare a mass concentration of 10% electrospinning solution, add the electrospinning solution into the syringe, and connect the front tube of the micropump and the spinning needle, and set the spinning voltage to 28.5kV , solution advancing speed 8mL / h, receiving distance 30cm. After electrospinning, the obtained electrospun membrane was placed in an air-blast drying oven at 50°C for 5 hours, then soaked in 75% alcohol for 1 hour, and then dried in a drying oven at 50°C overnight to obtain a polycaprolactone nanofiber membrane.

[0107]

[0108] A fiber thread made of 25 (1 cluster) PET fiber filaments was selected, and the fiber thread was fixed on the polycaprolactone nanofiber film by sewing to obtain a composite film. Among them, one fiber thread is made of a cluster of PET fibers, two fiber threads are a fiber thread group, the fiber threads in the same fiber thread group extend in the same direc...

Embodiment 3

[0114]

[0115] Use hexafluoroisopropanol to dissolve L-polylactic acid, prepare an electrospinning solution with a mass concentration of 20%, add the electrospinning solution into the syringe, connect the front tube of the micropump and the spinning needle, and set the spinning voltage to 35kV , solution advancing speed 2.5mL / h, receiving distance 30cm. After electrospinning, the obtained electrospun membrane was placed in a forced air drying oven at 50°C to dry for 5 hours, then soaked in 75% alcohol for 1 hour, and then placed in a drying oven to dry at 50°C overnight to obtain a L-polylactic acid nanofiber membrane.

[0116]

[0117] Use hexafluoroisopropanol to dissolve L-polylactic acid, configure the L-polylactic acid solution with a mass concentration of 8%, then add hydroxyapatite powder to the L-polylactic acid solution, and the mass of polylactic acid and hydroxyapatite The ratio is 5:2, stirred at a rotation speed of 1500 rpm for 30 minutes, introduced into a w...

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Abstract

The invention provides a bionic ligament and a bionic ligament system. The bionic ligament comprises a body part and branch parts, wherein the body part comprises a porous membrane and multiple fiber filaments, the body part is in a cylindrical shape which is formed by winding the porous membrane and provided with a cavity, the fiber filaments are fixed to the porous membrane, and at least one of the fiber filaments extends in the direction approximately same as the length direction of the body part; the branch parts extend out from the two ends in the length direction of the body part, the branch parts are connected with the part body, the free ends, away from the body part, of the branch parts can be bent along the radial outer side, and accordingly the free ends of the branch parts are separated from each other. The bionic ligament can promote new tissue growth, promotes bone-tunnel and bionic ligament three-dimensional fusion, can maintain the balance between mechanical attenuation of the bionic ligament and mechanical progressive increase of a new ligament, and accordingly stable mechanical support is provided.

Description

technical field [0001] The application relates to a bionic ligament and a bionic ligament system, belonging to the field of biomedicine. Background technique [0002] Ligaments are dense fibrous connective tissue bundles or connective tissue membranes that connect two adjacent bones or cartilage in a joint, and are interwoven by elastic fibers and collagen fibers. Ligaments are strong in tensile strength and have a certain degree of elasticity, which can maintain the stability of joints and limit their activities beyond the physiological range. In daily life and sports activities, the probability of ligament damage is very high, which directly leads to problems such as joint instability, synovitis, and hydrojoint, which have become health problems that cannot be ignored. [0003] Due to the poor self-repair ability of ligaments, the commonly used clinical treatment methods include autologous transplantation, homologous or heterogeneous tendon transplantation, and artificial...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/08A61L27/56A61L27/46A61L27/58
CPCA61F2/08A61F2/0811A61F2002/0817A61L27/46A61L27/56A61L27/58A61L2430/10C08L67/04C08L89/06
Inventor 李广耀袁玉宇
Owner MEDPRIN REGENERATIVE MEDICAL TECH
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