A drug-loaded protein particle and its preparation method

Abstract

The invention provides drug-loaded protein microparticles. The drug-loaded protein microparticles are prepared from protein and a drug, wherein a mass ratio of the protein to the drug is (5 to 7) to 1; the shape of the drug-loaded protein microparticles is spherical or approximately spherical. The invention also provides a preparation method of the drug-loaded protein microparticles. The preparation method comprises the following steps: adopting a consolute solution of the protein and the drug as a core solution; adopting an acid mixed solvent as a sheath solution; respectively controlling the speed of injecting working fluid of the core solution and the sheath solution into a coaxial spray nozzle through two axial flow pumps, starting a high-voltage generator, atomizing and drying the working fluid of the core solution and the sheath solution after passing through the coaxial spray nozzle under the action of high-voltage static electricity, and collecting through a foil wrapped hard board, thus obtaining the drug-loaded protein microparticles which are spherical or approximately spherical. The high-voltage electrostatic spraying drug-loaded protein microparticles provided by the invention are capable of providing a better drug sustained or controlled release effect. A preparation technology of the invention is simple, single steps are effective, and an effective implementation method can be provided for design and preparation of many drug micro-nano sustained or controlled release dosing systems.

Description

technical field

[0001] The invention belongs to the field of material science, and relates to a drug sustained and controlled release material, in particular to a drug-loaded protein particle and a preparation method thereof. Background technique

[0002] High-voltage electrostatic spray technology (referred to as EFI) is a top-down (top-down) micro-nano manufacturing technology. This technology overcomes the surface tension and viscoelastic force of the liquid droplets at the tip of the nozzle by applying an electric field force to form a jet. Under the joint action of electrostatic repulsion, Coulomb force and surface tension, the atomized liquid evaporates quickly due to its huge surface area, and the polymer solute is dried into fine micro-nano particles. The technical process is simple, easy to operate, a wide range of polymer materials can be selected, strong controllability, and continuous industrial production can be realized. The application of this technology to pr...

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