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Preparation method of drug loaded porous nanoparticle

A nanoparticle and drug-carrying technology, applied in pharmaceutical formulations, non-active medical preparations, drug combinations, etc., can solve problems such as easy decomposition and poor stability, and achieve increased curative effect, high yield, and simple and fast preparation process. Effect

Inactive Publication Date: 2017-05-31
SOUTHWEST UNIV
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  • Claims
  • Application Information

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Problems solved by technology

Curcumin (CUR) is an active substance extracted from the rhizomes of turmeric, turmeric and other plants in the ginger family. It is relatively safe for humans, but it is easy to decompose in a neutral and alkaline environment and has poor stability. Due to these defects, it has not been widely used in clinical practice

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  • Preparation method of drug loaded porous nanoparticle
  • Preparation method of drug loaded porous nanoparticle
  • Preparation method of drug loaded porous nanoparticle

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1 is the preparation method of loading CUR porous nanoparticles, comprising the following steps:

[0032] 1) Dissolve 100mg PLGA and 6mg CUR in 2mL dichloromethane to make a solution;

[0033] 2) adding 3% ammonium bicarbonate aqueous solution dropwise to the organic solution in step 1) while vortexing to form a mixed solution;

[0034] 3) Add the mixed solution of step 2) dropwise to 4mL 5% polyvinyl alcohol aqueous solution to form an emulsion;

[0035] 4) Immediately put the emulsion obtained in step 3) into an ice bath, and perform ultrasonication with an ultrasonic amplitude of 50%, 10 s each time, 1 s interval, and 1 min ultrasonic time;

[0036] 5) After the ultrasound is completed, quickly pour the above emulsion into 50 mL of 0.05% polyvinyl alcohol aqueous solution;

[0037] 6) At room temperature, after the organic solvent in the above emulsion was volatilized, the obtained nanoparticles were collected by centrifugation, and washed 3 times with d...

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Abstract

The invention discloses a preparation method of a drug loaded porous nanoparticle. Ammonium bicarbonate serving as a pore-foaming agent is introduced into the nanoparticle, observation through a scanning electron microscope shows that the nanoparticle is round or oval, and a plurality of pores are formed in the surface. Compared with the nanoparticle without a pore, the porous nanometer structure remarkably improves the drug release efficiency, so that the treatment efficiency of colitis is effectively strengthened.

Description

technical field [0001] The invention belongs to the technical field of nano drug carriers, and in particular relates to a preparation method and application of drug-loaded porous nanoparticles. Background technique [0002] Ulcerative colitis (UC) is the most important type of inflammatory bowel disease. The main clinical symptoms are diarrhea, blood in the stool, weight loss, abdominal pain, fatigue and fever. According to data, the incidence of ulcerative colitis is relatively high in European and American countries. Taking the United States as an example, the incidence rate is as high as 2‰. Symptoms of UC usually get worse over time. Traditional treatment drugs mainly include aminosalicylic acid drugs (such as 5-aminosalicylic acid), immunosuppressant drugs (such as methotrexate) and glucocorticoid drugs (such as budesonide). [0003] In recent years, micro- and nano-particles based on polylactic-co-glycolic acid (PLGA) have been widely studied, which have good biocomp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K47/34A61K47/04A61K31/12A61P1/00A61P1/04
CPCA61K9/5153A61K31/12A61K47/02
Inventor 肖波司笑莹陈秋冰
Owner SOUTHWEST UNIV