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Application of medicinal preparation to preparation of medicines for treating helicobacter pylori infectious diseases

A technology for Helicobacter pylori and infectious diseases, which is applied to the application field of pharmaceutical preparations in the preparation of medicines for treating Helicobacter pylori infectious diseases, can solve problems such as super drug-resistant bacteria, infectious diseases, and antibiotic abuse, and achieve compliance The effect of good sex, simple usage and high safety

Pending Publication Date: 2017-05-31
刘海涛
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] Eradication of gastric and duodenal Helicobacter pylori in a large number of people is an inevitable choice, but for the control of many bacterial infectious diseases in humans, it is necessary to use antibiotics to eradicate gastric and duodenal Helicobacter pylori infection. Indeed, the abuse of antibiotics will lead to the emergence of super-resistant bacteria, which will have extremely serious consequences for the control of bacterial infectious diseases in humans

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Example 1: Volunteer, male, adult, diagnosed with moderate to severe atrophic gastritis by ordinary endoscopy and biopsy, before eradication treatment, 14 C Helicobacter pylori test report (2016-4-25 13:18:5): DPM=2660, positive ++++ ; The pharmaceutical preparation used to eradicate Helicobacter pylori in the stomach and duodenum is an aqueous pharmaceutical preparation composed of iodine starch, potassium iodide and water, orally, 50ml each time, containing 3mg of iodine, once a day, for 5 consecutive days , taken on an empty stomach in the morning; no adverse reactions occurred during the medication. 1 month after drug withdrawal 14 C Helicobacter pylori test report (2016-6-20 13:17:5): DPM=182, positive + .

[0048] Conclusion: The test shows that the aqueous solution of the pharmaceutical preparation composed of iodine starch, potassium iodide and water has a significant effect on the eradication of Helicobacter pylori in the stomach and duodenum; better results...

Embodiment 2

[0050] Embodiment 1 Voluntary experimenter, use the aqueous solution of the pharmaceutical preparation that is made up of elemental iodine and potassium iodide instead to eradicate Helicobacter pylori in the stomach and duodenum, orally, 100ml each time, containing 15mg of iodine, once a day, and take it for 5 days , taken on an empty stomach in the morning; significant adverse reactions such as stomach discomfort, abdominal pain, nausea, and vomiting occurred during the medication and for a long time after drug withdrawal. Before eradication 14 C Helicobacter pylori test report (2016-6-20 13:17:5): DPM=182, positive + ; 1 month after drug withdrawal 14 C Helicobacter pylori test report (2016-8-8 10:10:02):: DPM=0, negative - .

[0051] Conclusion: The test shows that the aqueous solution of the pharmaceutical preparation composed of iodine element and potassium iodide has a very significant effect on the eradication of Helicobacter pylori in the stomach and duodenum; but t...

Embodiment 3

[0053] Volunteer, female, adult, diagnosed with chronic non-atrophic gastritis by painless gastroscopy, before eradication treatment 14 C Helicobacter pylori test report (2016-5-13 11:18:5): DPM=490, positive + .

[0054] The patient was treated according to the current routine treatment plan for eradicating Helicobacter pylori in the stomach and duodenum. Four drugs, including Polite 10mg, Livzon Dele 440mg, Amoxicillin 1000mg and clarithromycin 500mg, were administered in combination, and were taken orally. , 2 times a day for 14 consecutive days; nausea, vomiting and other significant adverse reactions occurred during the medication.

[0055] 1 month after drug withdrawal 14 C Helicobacter pylori test report (2016-6-20 13:20:3): DPM=245, positive + ; The results of the treatment showed that Helicobacter pylori in the stomach and duodenum had not been completely eradicated.

[0056] Change to the aqueous solution of pharmaceutical preparations composed of simple iodine a...

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Abstract

The invention relates to application of a medicinal preparation to preparation of medicines for treating helicobacter pylori infectious diseases. The medicinal preparation contains an iodine elementary substance or an iodine compound; molecular iodine exists in an aqueous solution of the medicinal preparation containing the iodine elementary substance or the iodine compound; the medicinal preparation containing the iodine elementary substance or the iodine compound is applied to the preparation of medicines for treating stomach and duodenal helicobacter pylori infectious diseases, can completely eliminate stomach and duodenal helicobacter pylori, is safe and effective, avoids medicine tolerance, has few and slight adverse effects, and is short in treatment course, convenient to take and low in price.

Description

technical field [0001] The invention relates to the application of a pharmaceutical preparation in the preparation of medicines for treating Helicobacter pylori infectious diseases. Background technique [0002] Helicobacter pylori infection is an infectious disease that is transmitted from person to person. [0003] Helicobacter pylori infection is a global problem. In 1994, it was listed as a class I carcinogen of human gastric cancer by the World Health Organization (WHO) and the International Agency For Research on Cancer (IARC), and Helicobacter pylori has become the only one so far to obtain such a dangerous level. bacteria. [0004] Helicobacter pylori mainly enters the human stomach through the oral cavity and colonizes the gastric epithelium. After colonization, the body is difficult to clear spontaneously, and almost all of them can cause active inflammation of the gastric mucosa. On the basis of active inflammation, chronic gastritis, A series of common disease...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/18A61K31/718A61P31/04A61P1/00
CPCA61K31/718A61K33/18A61K2300/00
Inventor 刘海涛
Owner 刘海涛
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