233 results about "Duodenum/Duodenal" patented technology

A device for ablating target tissue of a patient with electrical energy is provided. An elongate shaft includes a proximal portion and a distal portion, and a radially expandable element is attached to the distal portion. An ablation element for delivering electrical energy to target tissue is mounted to the radially expandable element. The device can be constructed and arranged to ablate the duodenal mucosa of a patient while avoiding damage to the duodenal adventitial tissue. Systems and methods of treating target tissue are also provided.

The invention provides a duodenal mucosa adjusting system and method based on pulsed electric field ablation and application of the duodenal mucosa adjusting system and method in diabetes treatment, the duodenal mucosa adjusting system comprises an intelligent control host capable of achieving bidirectional data transmission and an adjustable catheter, and the intelligent control host initializes parameters and adjusts pulse parameters by monitoring impedance data in real time until pulses are interrupted or terminated; periodic ablation is carried out, periodic intervals are used for measuring impedance data, the ablation depth is evaluated according to the impedance change rate, and whether next section ablation is carried out or not is judged till full-area ablation is completed. The far-end ablation adopts a structure of combining fusiform flexible support and annular electrode spiral arrangement to ensure that an ablation field uniformly covers mucous membrane plica of a duodenum bulb part and a descending part; a cell selective ablation mechanism is adopted, the critical electric field intensity is set, K cell electroporation is selectively induced, and meanwhile goblet cells are protected.

A device for ablating target tissue of a patient with electrical energy is provided. An elongate shaft includes a proximal portion and a distal portion, and a radially expandable element is attached to the distal portion. An ablation element for delivering electrical energy to target tissue is mounted to the radially expandable element. The device can be constructed and arranged to ablate the duodenal mucosa of a patient while avoiding damage to the duodenal adventitial tissue. Systems and methods of treating target tissue are also provided.

A system for targeted delivery of a medicament to the gastrointestinal tract (e.g., selectively to the duodenum) of a subject. The system includes a medicament, a mucoadhesive layer at least partially surrounding the medicament, and an enteric coating encasing the medicament and mucoadhesive layer. The enteric coating comprises a material degradable by a pH of the GI tract and a material digestible by a lipase. Also provided are method of making and using the system for targeted delivery of a medicament to the gastrointestinal tract. Also provided are a system for deploying a medicament-containing needle system using an expanding element. The system includes a medicament-containing needle system and an expanding element within a capsule. The capsule is initially coated with an enteric coating. As the enteric coating degrades the expanding element absorbs fluid that enters the capsule and expands to deploy the medicament-containing needle system from the capsule.

A method of forming an access route to the bile duct includes: forming a tunnel extending from an oral ridge of a duodenal papilla, which is located on an oral side of a natural opening of a duodenal papilla, to the bile duct; and dilating a lumen of the tunnel more than when it was formed.

The invention discloses a duodenoscope reprocessing detection method based on machine vision, particularly relates to the field of machine vision, and is used for solving the problem that residual pollutants are difficult to accurately position and remove after reprocessing of an existing duodenoscope. The method comprises the following steps of: applying illumination disturbance with controllable incident angle, wavelength and polarization state to the outer surface and the inner cavity of the duodenoscope, collecting an image sequence under the disturbance, and extracting a pixel block time sequence brightness response characteristic; calculating a brightness difference residual error and a consistency weight under different incident angles, identifying a candidate abnormal region, and generating a difference atlas reflecting the candidate abnormal region and a clean reference response characteristic parameter; carrying out segmentation, connectivity analysis and clustering on the difference atlas, and delimiting a three-dimensional space boundary of the pollution suspicious area in combination with three-dimensional coordinate continuity and curved surface normal consistency; directional cleaning and repeated detection are carried out in the range, and cyclic detection is carried out until the polluted area disappears, so that high-precision detection and efficient cleaning are realized.

The duodenal papilla dilatation balloon catheter with the pressure measuring function comprises an outer sheath tube, a combination body and a plurality of branch tubes, the outer sheath tube comprises a drainage tube section I, a drainage tube section II and a drainage tube section III which are sequentially connected from head to tail, and the surface of the drainage tube section II is wrapped with a double-layer cylindrical dilatation film; the double-layer cylindrical expansion membrane comprises an inner-layer membrane and an outer-layer membrane, the outer-layer membrane is provided with an opening, and a pressure sensor is arranged in the opening; the combined body is connected with the tail end of the drainage tube section III, and a plurality of branch tubes are connected with the combined body. According to the catheter, common bile duct or pancreatic duct intubation can be carried out under the assistance of the guide wire, the pressure between the balloon and the duodenal papilla sphincter can be detected while the duodenal papilla sphincter is expanded, the nipple expansion size is determined according to the pressure value, and the occurrence rate of complications such as tearing bleeding of the duodenal papilla sphincter, bile leakage and enterobiliary regurgitation is avoided.

The degradable duodenum bypass stent system comprises a tubular grid stent and a bypass membrane tube, one end of the bypass membrane tube is fixed to the tubular grid stent, the other end of the bypass membrane tube is a free end, the bypass membrane tube is communicated with the interior of the tubular grid stent, and the bypass membrane tube is arranged in the tubular grid stent. Anchor thorns capable of being embedded into a duodenum bulbar mucous membrane are arranged on the tubular grid stent; all components of the degradable duodenum bypass stent system are made of materials which can be degraded in the human digestive tract environment. All the components of the degradable duodenum bypass stent system are made of materials which can be degraded in the human digestive tract environment, the degraded components can be discharged out of the body through excrement, and then a secondary endoscopic extraction operation can be avoided.

Newborn congenital duodenal obstruction is an enteric cavity obstructive disease caused by fetal duodenal dysplasia, and is a common type in newborn digestive tract obstruction. The global morbidity is about 1 / 5000-1 / 10000 newborns, and the disease is more common in Asian people. Typical clinical manifestations of the disease include vomiting, epigastric distension and fetal stool discharge delay after birth, the invention provides a method for establishing a zebra fish model for simulating duodenum obstruction, and additionally provides a target design idea.

The present invention provides Irsogladine or a pharmaceutically acceptable salt thereof for use in the treatment and / or prevention of eosinophilic gastrointestinal diseases in mammals. The invention is useful in the treatment of eosinophilic gastritis, eosinophilic gastroenteritis, eosinophilic duodenitis, eosinophilic enteritis, eosinophilic colitis, and in particular, eosinophilic esophagitis. The invention is particularly useful for inducing disease remission in acute inflammatory activity and long-term maintenance of remission as well. The Irsogladine of the invention can be administered in the form of a pharmaceutical composition, or more specifically, in the form of an oral and rectal pharmaceutical composition.

The present application relates to the technical field of endoscopy, and particularly discloses a tube sheath and an endoscope system, the tube sheath comprising a tube sheath body, the tube sheath body having an axially-through first channel, and a second channel radially penetrating the tube sheath body and communicating with the first channel being arranged at the distal end of the tube sheath body; in the above scheme, in the insertion stage of the tube sheath body, the endoscope can clearly see the tissue structure and obstacles in front through the first channel, improving the visibility of the insertion process and reducing the risk of blind insertion, and after the tube sheath body reaches the target position, the endoscope can be retracted so that the front end thereof is located at the communication position of the first channel and the second channel, and then the endoscope is operated so that the front end thereof is bent and inserted into the second channel, based on the guiding effect of the second channel on the front end of the endoscope, so that the endoscope can accurately enter the common bile duct from the side of the tube sheath body, thereby avoiding the dependence of the endoscope on the duodenoscope when exploring the common bile duct, and reducing the cost.

Embodiments of the present application provide a duodenum-based electric field ablation method, system and device, the method comprising: in the case of determining a target tissue corresponding to a target object, determining the narrow pulse parameters required by the target tissue; wherein the target tissue is the position of the target object's duodenum that needs to be subjected to pulse electric field ablation; determining the state information of the main control system; detecting the state information, and in the case that the state information meets the preset condition, generating a first pulse and a second pulse based on the narrow pulse parameters through the driving of the H-bridge circuit; wherein the preset condition is that the state information of the main control system meets the preset state; performing phase shift control processing based on the first pulse and the second pulse to determine the narrow pulse corresponding to the narrow pulse parameters; and achieving electric field ablation of the target tissue through multiple electrodes based on the narrow pulse. In the above scheme, the stability of the output of the narrow pulse is improved, thereby improving the electric field ablation effect on the duodenum.

A device can include a capsule containing an array of microneedles and a mechanical actuator. The device can be in an ingestible form for delivery to a duodenum or other target location within a subject and can release a first shell portion and a second shell portion of the capsule from one another in response to stimuli or conditions in or en route to the duodenum or other target location. The launcher can drive the released first shell portion and the second shell portion away from one another to expose the array of microneedles in a position for achieving penetrating engagement with a lining of the duodenum or other target location. The penetrating engagement can facilitate delivery of a biotherapeutic agent or other payload via the microneedles.

The utility model relates to an automatic adjustment hepatic duodenal ligament portal vein and hepatic arterial blood flow on-off device which comprises a soft rubber sleeve, a handle, a connecting pipe, a first clamping strip, a second clamping strip, a rotating shaft, a flexible wire and a flexible wire control mechanism. The first clamping strip and the second clamping strip are sleeved with the soft rubber sleeve, one end of the connecting pipe is connected to the soft rubber sleeve, the other end of the connecting pipe is connected to the handle, the flexible wire control mechanism is arranged on the handle, the flexible wire is inserted into the connecting pipe in a penetrating mode, one end of the flexible wire is connected to the first clamping strip, and the other end of the flexible wire is connected to the flexible wire control mechanism. According to the utility model, the defects of the existing porta hepatis occlusion technology can be overcome, more accurate, safer and more convenient blood flow occlusion and conduction control can be realized, and the surgical risk and liver injury can be reduced.

This invention relates to the crystal form of vonorazine pyroglutamate and its preparation method. The vonorazine pyroglutamate crystal form obtained by this invention not only has good solubility but also excellent storage stability; in vitro activity experiments show that crystal form I of this invention is effective against H+. + K + The inhibitory effect of ATPase is comparable to that of TAK-438; animal experiments show that the crystal form of the present invention, when administered intravenously, can significantly inhibit histamine-induced gastric acid secretion in rats, and can exert its pharmacological effect faster than that of TAK-438 administered duodenally.

The utility model discloses a mould is placed under the mould of simulation ultrasonic real -time guidance of nasal -intestinal tube, including the digestive tract simulation body of simulation esophagus, stomach, duodenum and jejunum, it adopts the flexible material of ultrasonic wave penetration, front surface is not transparent, back surface is transparent, and its inside esophagus is used for filling air, and the part except esophagus is used for filling liquid, the digestive tract simulation body is fixed between two organic glass, front surface is not transparent, back surface is transparent, the organic glass of front surface opens at esophagus place, antrum gastricum place respectively, as the acoustic window of ultrasonic, is used for the inflation sign of esophagus and antrum gastricum nasal -intestinal tube catheter tip cloud sign of ultrasonic observation when placing nasal -intestinal tube respectively, is provided with many resistance positions at stomach and duodenum, for making nasal -intestinal tube catheter tip forward into the obstruction. The utility model can simulate the sign of ultrasonic under different conditions on the mould, effectively simulates the actual entering process of nasal -intestinal tube under the real -time guidance of ultrasonic, and facilitates simulation teaching demonstration.

The invention discloses an anti-winding intestinal obstruction catheter system and method. The anti-winding intestinal obstruction catheter system comprises a handle, a catheter body and a rigidity adjusting device. The catheter body is a flexible body, the near end of the catheter body is connected with the handle, and the far end of the catheter body is provided with a balloon and a charging pipeline communicated with the balloon; the rigidity adjusting device is connected with the catheter body and used for adjusting the bending rigidity of the catheter body after the catheter body is placed into the duodenum. The anti-winding intestinal obstruction catheter system is adopted in the catheter indwelling method of the anti-winding intestinal obstruction catheter, and the anti-winding intestinal obstruction catheter system and method can effectively prevent the catheter from being wound, improve the catheter indwelling success rate and ensure the operation safety at the same time.

Described here are methods that may help predict a positive response of a patient to pulsed electric field treatment of intestinal tissue. The methods may include selecting a patient for treatment based on their baseline ferritin level. When the patient has a metabolic condition such as diabetes (e.g., Type 1 or Type 2 diabetes), the positive response may include a decrease in HbA1c level. The degree of the positive response may be dependent on the baseline ferritin level, with higher baseline ferritin levels being associated with a greater positive response.

A cryoablation catheter (1) and a cryoablation catheter system provided with the cryoablation catheter (1), the cryoablation catheter (1) for duodenal papilla insertion being provided with: an outer tube (10); a cryoablation catheter (1) includes an outer tube (10) having a lumen (15), and a first inner tube (210) disposed in the lumen (15) of the outer tube (10), the first inner tube (210) having a guidewire lumen (211) and a plurality of supply lumens (212), the cryoablation catheter (1) having a first discharge flow path (31) between an inner surface (14) of the outer tube (10) and an outer surface (213) of the first inner tube (210), and a hole (40) formed in a distal portion of the first inner tube (210) and communicating the supply lumens (212) and the first discharge flow path (31).

A method for performing an endoscopy procedure can include viewing an image of a wall of a duodenum proximate a papilla using an endoscope, releasing through a cannula of the endoscope a fluid towards the papilla while viewing the image, and inserting an instrument through an opening of the papilla after releasing the fluid. A system can include an endoscope, a cannula system including a cannula extending through the endoscope, a fluid control system coupled to the cannula system, the fluid control system including a source of saline and a source of a freezing agent, and a fluid activator, wherein the fluid activator is configured to deliver at least one of the saline and the freezing agent through the cannula at a user's discretion.

Disclosed are an endoscope forceps elevator, an endoscope distal end and a duodenoscope system. The bottom of the endoscope forceps elevator is in communication with an instrument channel and the endoscope forceps elevator is provided with a hinge part configured to be hinged with an endoscope distal end base; a positioning groove adapted to an instrument to be positioned is provided at the top of the endoscope forceps elevator; and a cutting edge and a guide surface are provided at a side of the endoscope forceps elevator, and the guide surface is located between the positioning groove and the cutting edge. The cutting edge is movable in contact with the inner side surface of the distal end base so as to guide the instrument to be positioned in a first deflected and extended state onto the guide surface.

A magnesium aluminum carbonate double-layer tablet is obtained by pressing a magnesium aluminum carbonate common layer and a magnesium aluminum carbonate sustained-release layer, wherein the magnesium aluminum carbonate common layer contains magnesium aluminum carbonate as a main drug, and the auxiliary materials are a filler and a disintegrant, and the magnesium aluminum carbonate sustained-release layer contains magnesium aluminum carbonate as a main drug, and the auxiliary materials are a drug administration rate regulator, a gastric floating additive, a swelling agent, a foaming agent, and a hydrophilic gel. The magnesium aluminum carbonate double-layer tablet prepared by the present invention has a stable performance within 24 months, and the main drug content of the common layer and the sustained-release layer hardly changes. The common layer of the magnesium aluminum carbonate double-layer tablet can be completely peeled off from the sustained-release layer in about 30 seconds and sink into the lower layer, quickly neutralizing gastric acid and taking effect quickly. At the same time, the sustained-release layer has a release time of up to 4 hours after forming a floating layer, which proves that the magnesium aluminum carbonate double-layer tablet has a sustained-release effect within 4 hours after administration, and can effectively prolong the treatment time of patients with gastric ulcer and duodenal ulcer.

Provided is a medical support device including a processor. The processor is configured to specify a papilla type, which is a type of a duodenal papilla, by executing image recognition processing on an intestinal wall image obtained by imaging an intestinal wall including the duodenal papilla in a duodenum with a camera provided in an endoscope scope; and output related information related to the papilla type.

The invention discloses a free directional guide visual guide wire mirror device. The device mainly comprises a handheld handle, an imaging optical fiber, an illumination optical fiber, a miniature view finding objective lens group, a photoelectric conversion image acquisition group, a flexible outer sleeve and a front-end free directional guide end, and the outer diameter of the device is smaller than 0.9 mm. And through a unique free directional guiding function, the visual probe can enter a superfine lumen and a narrow part for visual exploration on the premise of not damaging the mucous membrane of the cavity. The endoscope can be applied to medical scenes such as fallopian tube cavity examination, assistance of a duodenoscope in bile duct operation and the like, the application limitation of a traditional endoscope is effectively broken through, ray radiation hazards are reduced, the cross infection risk is reduced, and an innovative technical means is provided for medical diagnosis and treatment.

The duodenal papilla sphincter incision knife with the pressure measuring function comprises an outer sheath tube, a guide wire, a metal wire and a handle, the outer sheath tube comprises a drainage tube section I, a drainage tube section II, a drainage tube section III and a drainage tube section IV which are sequentially connected from head to tail, and the handle is connected with the tail end of the drainage tube section IV. A mounting groove is formed in the tube wall of the drainage tube section II, a pressure sensor is arranged in the mounting groove, one end of a metal wire is connected with the tube wall of the outer sheath tube, and the other end of the metal wire is inserted into the outer sheath tube and the handle; the guide wire is inserted through the handle, sequentially penetrates through the drainage tube section IV, the drainage tube section III, the drainage tube section II and the drainage tube section I and penetrates out. According to the invention, common bile duct or pancreatic duct intubation can be carried out under the assistance of the guide wire, the pressure of common bile duct, pancreatic duct and duodenal papilla sphincter is detected while papilla sphincter is incised under an endoscope, and the incised size of the papilla sphincter is determined according to the pressure value, so that the papilla sphincter is prevented from being incised too small or too large.

The invention relates to the field of medical instruments, and discloses a novel precise duodenal papilla windowing knife which comprises a handle body, a needle tube body is fixedly connected to one side of the handle body, an injection connector and a guide wire access port are arranged on the outer side of the handle body, and a needle knife is arranged at the end, away from the handle body, of the needle tube body. A traction wire is slidably connected into the needle tube body, a flushing assembly is fixedly mounted on the side wall of the handle body, a sliding handle is slidably connected to the outer side of the handle body, a high-frequency electrode is fixedly mounted on the surface of the sliding handle, and an adjusting assembly is mounted on the side, away from the needle knife, of the handle body. According to the structure of the needle knife, the knife outlet length of the needle knife can be conveniently adjusted, and the operation in the windowing operation process is more convenient.

The present invention provides a tegoprazan sugar acid salt and a preparation method therefor, the salt being pharmaceutically usable for gastroesophageal disease, gastroesophageal reflux disease, gastritis, peptic ulcer, gastric ulcer, duodenal ulcer, NSAID-induced ulcer, non-erosive reflux disease (NERD) and the like. The tegoprazan sugar acid salt of the present invention has excellent water solubility and stability of tegoprazan, and thus can be particularly useful as a pharmaceutical injection preparation.

The present application relates to the field of pet feed, and discloses a maintenance ration formula for improving the smoothness of dog hair. The formula comprises base ration particles and lipid microcapsules attached to the surface of the base ration particles; the lipid microcapsules encapsulate a core material composed of essential fatty acids and ceramides, have a double-layer wall material structure, and the outer layer is acid-resistant plant gum and the inner layer is lipase-sensitive phospholipid; the microcapsules are attached to the surface of the puffed base ration by low-temperature vacuum spraying. The present application makes the microcapsules resistant to gastric acid and releases the core material under the action of duodenal lipase, targets and enriches in sebaceous glands through the lymphatic system, solves the problems of low lipid delivery conversion rate and insufficient substrate of sebaceous glands, improves the proportion of sebaceous gland ceramides, and reduces the hair friction coefficient.

The invention belongs to the technical field of biomedical information analysis, and particularly relates to duodenum mucosa surface replacement and electrotransfection integrated equipment and a parameter feedback-based operation method. The invention firstly provides a duodenum mucosa surface replacement and electrotransfection integrated device. The device comprises an endoscope guide module, a radio frequency ablation module, an electrotransfection module and an intelligent terminal control module. The invention further provides a method for operating the DMR-EP integrated equipment based on organization parameter feedback. According to the method, individualized strategy generation and data-driven treatment path selection in DMR postoperative local gene therapy are proposed for the first time, and the safety, effectiveness and indication range of treatment are remarkably improved.

Neonatal congenital duodenal obstruction is an intestinal lumen obstructive disease caused by abnormal development of the duodenum during fetal period, and it is a relatively common type among neonatal digestive tract obstructions. Its global incidence is approximately 1 / 5000 to 1 / 10000 neonates, and it is more common in Asian populations. The typical clinical manifestations of this disease include vomiting, upper abdominal distension, and delayed passage of meconium after birth. The present invention provides a method for establishing a zebrafish model for simulating duodenal obstruction, and additionally provides a design idea for the target.