306 results about "Duodenum/Duodenal" patented technology

The invention relates to the field of medical physics, and discloses a control method and system for pulse electric field ablation of duodenum, and the method comprises the steps: determining a multi-target tissue, needing pulse electric field ablation, of the duodenum corresponding to a target user, collecting a target tissue image of the multi-target tissue, and constructing a multi-tissue three-dimensional model of the multi-target tissue; analyzing tissue parameters of the multi-target tissue, and analyzing electric field intensity and pulse parameters required for ablation of the multi-target tissue; multiple electrodes of the ablation equipment are configured, and multiple electrode implantation sites of the multiple electrodes are determined; constructing a digestive tract model from the corresponding oral cavity to the duodenum of a target user, analyzing an ideal transmission path of multiple electrodes, analyzing a path deviation coefficient of a simulation transmission path and the ideal transmission path, correcting the simulation transmission path, transmitting the multiple electrodes to a multi-electrode implantation site, and then performing multi-electrode implantation. And pulse electric field ablation of multi-target tissues is realized by utilizing multiple electrodes. The precise ablation effect of the pulsed electric field can be improved.

A device for ablating target tissue of a patient with electrical energy is provided. An elongate shaft includes a proximal portion and a distal portion, and a radially expandable element is attached to the distal portion. An ablation element for delivering electrical energy to target tissue is mounted to the radially expandable element. The device can be constructed and arranged to ablate the duodenal mucosa of a patient while avoiding damage to the duodenal adventitial tissue. Systems and methods of treating target tissue are also provided.

The invention provides a duodenal mucosa adjusting system and method based on pulsed electric field ablation and application of the duodenal mucosa adjusting system and method in diabetes treatment, the duodenal mucosa adjusting system comprises an intelligent control host capable of achieving bidirectional data transmission and an adjustable catheter, and the intelligent control host initializes parameters and adjusts pulse parameters by monitoring impedance data in real time until pulses are interrupted or terminated; periodic ablation is carried out, periodic intervals are used for measuring impedance data, the ablation depth is evaluated according to the impedance change rate, and whether next section ablation is carried out or not is judged till full-area ablation is completed. The far-end ablation adopts a structure of combining fusiform flexible support and annular electrode spiral arrangement to ensure that an ablation field uniformly covers mucous membrane plica of a duodenum bulb part and a descending part; a cell selective ablation mechanism is adopted, the critical electric field intensity is set, K cell electroporation is selectively induced, and meanwhile goblet cells are protected.

A device for ablating target tissue of a patient with electrical energy is provided. An elongate shaft includes a proximal portion and a distal portion, and a radially expandable element is attached to the distal portion. An ablation element for delivering electrical energy to target tissue is mounted to the radially expandable element. The device can be constructed and arranged to ablate the duodenal mucosa of a patient while avoiding damage to the duodenal adventitial tissue. Systems and methods of treating target tissue are also provided.

The present invention provides a multi-stage duodenal papilla expansion balloon catheter, comprising a balloon group, a catheter, an injection-molded connector and a connecting pipe joint; the balloon group comprises a first balloon, a second balloon and a third balloon; the catheter comprises a first drainage tube segment, a second drainage tube segment, a third drainage tube segment, a fourth drainage tube segment and a fifth drainage tube segment; a first channel is arranged in the first drainage tube segment; a second channel and a third channel are arranged in the second drainage tube segment; a fourth channel, a fifth channel and a sixth channel are arranged in the third drainage tube segment; a seventh channel, an eighth channel, a ninth channel and a tenth channel are arranged in the fourth drainage tube segment; the fifth drainage tube segment is an extension tube of the fourth drainage tube segment; the connecting pipe joint comprises a first connecting joint, a second connector, a third connector and a fourth connector; each channel in the fifth drainage tube segment is connected to a corresponding connector. The present invention can increase the effective expansion range of the nipple sphincter, avoid the occurrence of nipple tearing and bleeding, has low pressure requirements and is simple to operate.

A system for targeted delivery of a medicament to the gastrointestinal tract (e.g., selectively to the duodenum) of a subject. The system includes a medicament, a mucoadhesive layer at least partially surrounding the medicament, and an enteric coating encasing the medicament and mucoadhesive layer. The enteric coating comprises a material degradable by a pH of the GI tract and a material digestible by a lipase. Also provided are method of making and using the system for targeted delivery of a medicament to the gastrointestinal tract. Also provided are a system for deploying a medicament-containing needle system using an expanding element. The system includes a medicament-containing needle system and an expanding element within a capsule. The capsule is initially coated with an enteric coating. As the enteric coating degrades the expanding element absorbs fluid that enters the capsule and expands to deploy the medicament-containing needle system from the capsule.

A method of forming an access route to the bile duct includes: forming a tunnel extending from an oral ridge of a duodenal papilla, which is located on an oral side of a natural opening of a duodenal papilla, to the bile duct; and dilating a lumen of the tunnel more than when it was formed.

The utility model relates to a double-J type self-falling pancreatic duct support device which comprises a drainage section catheter, a pancreatic duct fixing part and a duodenum fixing part, the pancreatic duct fixing part and the duodenum fixing part are fixed at the two ends of the drainage section catheter respectively, the pancreatic duct fixing part is of an arc-shaped structure, the duodenum fixing part is of an O-shaped structure, and the drainage section catheter and the duodenum fixing part are integrally formed. One end of the arc-shaped structure is connected with the drainage section catheter in the tangential direction of the arc, the other end of the arc-shaped structure extends by a certain distance in the tangential direction of the arc, and the O-shaped structure of the duodenum fixing part is connected with the drainage section catheter in the tangential direction of the arc. By adopting the double-J-shaped self-falling pancreatic duct support device, arc structures with different radians can be adopted according to the requirement of clinical pancreatic duct drainage time, so that the pancreatic duct support device can automatically fall in different time. The pancreatic duct can be retrograde placed under a duodenoscope to replace an existing hard plastic support or a double-J-shaped support which cannot fall off automatically, and therefore secondary endoscopic treatment is avoided.

The invention discloses an endoscope weight reduction support which comprises an upper reducing supporting body, a lower reducing supporting body, a connecting pipe and a membrane pipe. The upper reducing support body and the lower reducing support body are connected through a connecting pipe; and the membrane tube is fixed on the lower reducing support body. The degradable stent is prepared from a poly (p-dioxanone) material, and the degradable stent does not need to be taken out and can be automatically degraded and discharged, so that the step of taking out the stent is omitted, the cost and the risk are reduced, and the comfort of a patient is improved. The fixing effect is more stable, stent displacement is avoided, and stimulation of stent barbs to duodenum bulbar mucosa is avoided; the degradable stent is prepared from a poly (p-dioxanone) material, and the degradable stent does not need to be taken out and can be automatically degraded and discharged, so that the step of taking out the stent is omitted, the cost and the risk are reduced, and the comfort of a patient is improved.

An endoscope (e.g., a duodenoscope) includes a bifluidic valve for controlling the flow of water and air through a flexible tubular probe to respectively irrigate or insufflate an internal cavity of a patient. Some examples of the bifluidic valve include a flexible valve seal that allows air to flow in one direction but not in reverse. Different examples of the valve seal include various features, such as a set of overlapping flexible flaps arranged in a spiral, a rubber-like disc with an array of cross-slit perforations that open in response to a positive pressure differential across the disc, a resiliently expandable cone with multiple concentric ridges, a valve spool encircled by an elastic tubular piece that can expand radially to open an air passageway in the valve spool, and an elastic tube that in reaction to being compressed or otherwise shortened bulges radially outward to block an annular air passageway.

The invention discloses a duodenoscope reprocessing detection method based on machine vision, particularly relates to the field of machine vision, and is used for solving the problem that residual pollutants are difficult to accurately position and remove after reprocessing of an existing duodenoscope. The method comprises the following steps of: applying illumination disturbance with controllable incident angle, wavelength and polarization state to the outer surface and the inner cavity of the duodenoscope, collecting an image sequence under the disturbance, and extracting a pixel block time sequence brightness response characteristic; calculating a brightness difference residual error and a consistency weight under different incident angles, identifying a candidate abnormal region, and generating a difference atlas reflecting the candidate abnormal region and a clean reference response characteristic parameter; carrying out segmentation, connectivity analysis and clustering on the difference atlas, and delimiting a three-dimensional space boundary of the pollution suspicious area in combination with three-dimensional coordinate continuity and curved surface normal consistency; directional cleaning and repeated detection are carried out in the range, and cyclic detection is carried out until the polluted area disappears, so that high-precision detection and efficient cleaning are realized.

The duodenal papilla dilatation balloon catheter with the pressure measuring function comprises an outer sheath tube, a combination body and a plurality of branch tubes, the outer sheath tube comprises a drainage tube section I, a drainage tube section II and a drainage tube section III which are sequentially connected from head to tail, and the surface of the drainage tube section II is wrapped with a double-layer cylindrical dilatation film; the double-layer cylindrical expansion membrane comprises an inner-layer membrane and an outer-layer membrane, the outer-layer membrane is provided with an opening, and a pressure sensor is arranged in the opening; the combined body is connected with the tail end of the drainage tube section III, and a plurality of branch tubes are connected with the combined body. According to the catheter, common bile duct or pancreatic duct intubation can be carried out under the assistance of the guide wire, the pressure between the balloon and the duodenal papilla sphincter can be detected while the duodenal papilla sphincter is expanded, the nipple expansion size is determined according to the pressure value, and the occurrence rate of complications such as tearing bleeding of the duodenal papilla sphincter, bile leakage and enterobiliary regurgitation is avoided.

The invention provides a digestive tract lesion analysis method and system based on gastroscopy results and a medium. The method comprises the following steps: acquiring esophageal examination characteristic parameters, stomach examination characteristic parameters and duodenum examination characteristic parameters, calculating to obtain an upper digestive tract lesion risk index and a digestive tract comprehensive lesion risk index, and comparing the digestive tract comprehensive lesion risk index with a preset digestive tract comprehensive lesion risk threshold to obtain a digestive tract lesion level, obtaining a corresponding treatment scheme according to the lesion level of the digestive tract; therefore, by combining calculation of the upper digestive tract lesion risk index and the digestive tract comprehensive lesion risk index with threshold comparison, digestive tract lesion analysis is achieved, and a corresponding processing scheme is obtained.

The invention relates to an aleppo avens n-acetone extract and application thereof in treating necrotic enteritis. The aleppo avens n-acetone extract is obtained through a reflux extraction method, and the extraction conditions are as follows: the acetone concentration is 50% or 75%, the reaction time is 0.5 h or 1 h, the material-liquid ratio is 1: 5 or 1: 10, and the extraction temperature is 65 DEG C. According to the invention, a reflux extraction method is adopted to extract the aleppo avens, and the obtained aleppo avens n-acetone extract contains various compounds such as ellagic acid, buddleoside, 4, 4 '-dimethyl ellagic acid and the like; the aleppo avens n-acetone extract can increase the villus height of duodenum and jejunum and the ratio of villus height to crypt depth, maintain the morphological structure in the duodenum intestinal tract, increase the content of acetic acid, propionic acid and butyric acid in cecum, and significantly reduce necrotic enteritis lesion.

The degradable duodenum bypass stent system comprises a tubular grid stent and a bypass membrane tube, one end of the bypass membrane tube is fixed to the tubular grid stent, the other end of the bypass membrane tube is a free end, the bypass membrane tube is communicated with the interior of the tubular grid stent, and the bypass membrane tube is arranged in the tubular grid stent. Anchor thorns capable of being embedded into a duodenum bulbar mucous membrane are arranged on the tubular grid stent; all components of the degradable duodenum bypass stent system are made of materials which can be degraded in the human digestive tract environment. All the components of the degradable duodenum bypass stent system are made of materials which can be degraded in the human digestive tract environment, the degraded components can be discharged out of the body through excrement, and then a secondary endoscopic extraction operation can be avoided.

Newborn congenital duodenal obstruction is an enteric cavity obstructive disease caused by fetal duodenal dysplasia, and is a common type in newborn digestive tract obstruction. The global morbidity is about 1 / 5000-1 / 10000 newborns, and the disease is more common in Asian people. Typical clinical manifestations of the disease include vomiting, epigastric distension and fetal stool discharge delay after birth, the invention provides a method for establishing a zebra fish model for simulating duodenum obstruction, and additionally provides a target design idea.

The present invention provides Irsogladine or a pharmaceutically acceptable salt thereof for use in the treatment and / or prevention of eosinophilic gastrointestinal diseases in mammals. The invention is useful in the treatment of eosinophilic gastritis, eosinophilic gastroenteritis, eosinophilic duodenitis, eosinophilic enteritis, eosinophilic colitis, and in particular, eosinophilic esophagitis. The invention is particularly useful for inducing disease remission in acute inflammatory activity and long-term maintenance of remission as well. The Irsogladine of the invention can be administered in the form of a pharmaceutical composition, or more specifically, in the form of an oral and rectal pharmaceutical composition.

The invention discloses a compound preparation capsule and a preparation method thereof, wherein the compound preparation capsule is composed of Vonoprasone or a pharmaceutical salt microtablet thereof, an amoxicillin microtablet and a rifampicin or rifampetine microtablet. The Vonoprazan is a novel potassium ion competitive acid blocker, and the compound preparation capsule is used for treating gastric ulcer, duodenal ulcer, gastric MALT lymphoma, idiopathic thrombocytopenic purpura, and helicobacter pylori infection and helicobacter pylori infection gastritis in the stomach after early gastric cancer endoscopic therapy. According to the compound preparation capsule, the cure rate of helicobacter pylori can be increased, the drug resistance can be reduced, and a better treatment choice is provided for clinical patients.

The present application relates to the technical field of endoscopy, and particularly discloses a tube sheath and an endoscope system, the tube sheath comprising a tube sheath body, the tube sheath body having an axially-through first channel, and a second channel radially penetrating the tube sheath body and communicating with the first channel being arranged at the distal end of the tube sheath body; in the above scheme, in the insertion stage of the tube sheath body, the endoscope can clearly see the tissue structure and obstacles in front through the first channel, improving the visibility of the insertion process and reducing the risk of blind insertion, and after the tube sheath body reaches the target position, the endoscope can be retracted so that the front end thereof is located at the communication position of the first channel and the second channel, and then the endoscope is operated so that the front end thereof is bent and inserted into the second channel, based on the guiding effect of the second channel on the front end of the endoscope, so that the endoscope can accurately enter the common bile duct from the side of the tube sheath body, thereby avoiding the dependence of the endoscope on the duodenoscope when exploring the common bile duct, and reducing the cost.

Embodiments of the present application provide a duodenum-based electric field ablation method, system and device, the method comprising: in the case of determining a target tissue corresponding to a target object, determining the narrow pulse parameters required by the target tissue; wherein the target tissue is the position of the target object's duodenum that needs to be subjected to pulse electric field ablation; determining the state information of the main control system; detecting the state information, and in the case that the state information meets the preset condition, generating a first pulse and a second pulse based on the narrow pulse parameters through the driving of the H-bridge circuit; wherein the preset condition is that the state information of the main control system meets the preset state; performing phase shift control processing based on the first pulse and the second pulse to determine the narrow pulse corresponding to the narrow pulse parameters; and achieving electric field ablation of the target tissue through multiple electrodes based on the narrow pulse. In the above scheme, the stability of the output of the narrow pulse is improved, thereby improving the electric field ablation effect on the duodenum.

A device can include a capsule containing an array of microneedles and a mechanical actuator. The device can be in an ingestible form for delivery to a duodenum or other target location within a subject and can release a first shell portion and a second shell portion of the capsule from one another in response to stimuli or conditions in or en route to the duodenum or other target location. The launcher can drive the released first shell portion and the second shell portion away from one another to expose the array of microneedles in a position for achieving penetrating engagement with a lining of the duodenum or other target location. The penetrating engagement can facilitate delivery of a biotherapeutic agent or other payload via the microneedles.

The utility model relates to an automatic adjustment hepatic duodenal ligament portal vein and hepatic arterial blood flow on-off device which comprises a soft rubber sleeve, a handle, a connecting pipe, a first clamping strip, a second clamping strip, a rotating shaft, a flexible wire and a flexible wire control mechanism. The first clamping strip and the second clamping strip are sleeved with the soft rubber sleeve, one end of the connecting pipe is connected to the soft rubber sleeve, the other end of the connecting pipe is connected to the handle, the flexible wire control mechanism is arranged on the handle, the flexible wire is inserted into the connecting pipe in a penetrating mode, one end of the flexible wire is connected to the first clamping strip, and the other end of the flexible wire is connected to the flexible wire control mechanism. According to the utility model, the defects of the existing porta hepatis occlusion technology can be overcome, more accurate, safer and more convenient blood flow occlusion and conduction control can be realized, and the surgical risk and liver injury can be reduced.

This invention relates to the crystal form of vonorazine pyroglutamate and its preparation method. The vonorazine pyroglutamate crystal form obtained by this invention not only has good solubility but also excellent storage stability; in vitro activity experiments show that crystal form I of this invention is effective against H+. + K + The inhibitory effect of ATPase is comparable to that of TAK-438; animal experiments show that the crystal form of the present invention, when administered intravenously, can significantly inhibit histamine-induced gastric acid secretion in rats, and can exert its pharmacological effect faster than that of TAK-438 administered duodenally.

The utility model discloses a mould is placed under the mould of simulation ultrasonic real -time guidance of nasal -intestinal tube, including the digestive tract simulation body of simulation esophagus, stomach, duodenum and jejunum, it adopts the flexible material of ultrasonic wave penetration, front surface is not transparent, back surface is transparent, and its inside esophagus is used for filling air, and the part except esophagus is used for filling liquid, the digestive tract simulation body is fixed between two organic glass, front surface is not transparent, back surface is transparent, the organic glass of front surface opens at esophagus place, antrum gastricum place respectively, as the acoustic window of ultrasonic, is used for the inflation sign of esophagus and antrum gastricum nasal -intestinal tube catheter tip cloud sign of ultrasonic observation when placing nasal -intestinal tube respectively, is provided with many resistance positions at stomach and duodenum, for making nasal -intestinal tube catheter tip forward into the obstruction. The utility model can simulate the sign of ultrasonic under different conditions on the mould, effectively simulates the actual entering process of nasal -intestinal tube under the real -time guidance of ultrasonic, and facilitates simulation teaching demonstration.

The invention discloses an anti-winding intestinal obstruction catheter system and method. The anti-winding intestinal obstruction catheter system comprises a handle, a catheter body and a rigidity adjusting device. The catheter body is a flexible body, the near end of the catheter body is connected with the handle, and the far end of the catheter body is provided with a balloon and a charging pipeline communicated with the balloon; the rigidity adjusting device is connected with the catheter body and used for adjusting the bending rigidity of the catheter body after the catheter body is placed into the duodenum. The anti-winding intestinal obstruction catheter system is adopted in the catheter indwelling method of the anti-winding intestinal obstruction catheter, and the anti-winding intestinal obstruction catheter system and method can effectively prevent the catheter from being wound, improve the catheter indwelling success rate and ensure the operation safety at the same time.

1. The name of the product of this design: Duodenal jejunal internal cannula device. 2. Purpose of the product of this design: used for the insertion and removal of medical products in the digestive tract. 3. The design key point of this appearance design product lies in the shape. 4. The picture or photo that best illustrates the key points of the design: 3D drawing of Design 1. 5. Designate Design 1 as the base design. 6. The product of this design is a slender object, and its length is omitted.

Described here are methods that may help predict a positive response of a patient to pulsed electric field treatment of intestinal tissue. The methods may include selecting a patient for treatment based on their baseline ferritin level. When the patient has a metabolic condition such as diabetes (e.g., Type 1 or Type 2 diabetes), the positive response may include a decrease in HbA1c level. The degree of the positive response may be dependent on the baseline ferritin level, with higher baseline ferritin levels being associated with a greater positive response.

A cryoablation catheter (1) and a cryoablation catheter system provided with the cryoablation catheter (1), the cryoablation catheter (1) for duodenal papilla insertion being provided with: an outer tube (10); a cryoablation catheter (1) includes an outer tube (10) having a lumen (15), and a first inner tube (210) disposed in the lumen (15) of the outer tube (10), the first inner tube (210) having a guidewire lumen (211) and a plurality of supply lumens (212), the cryoablation catheter (1) having a first discharge flow path (31) between an inner surface (14) of the outer tube (10) and an outer surface (213) of the first inner tube (210), and a hole (40) formed in a distal portion of the first inner tube (210) and communicating the supply lumens (212) and the first discharge flow path (31).

A method for performing an endoscopy procedure can include viewing an image of a wall of a duodenum proximate a papilla using an endoscope, releasing through a cannula of the endoscope a fluid towards the papilla while viewing the image, and inserting an instrument through an opening of the papilla after releasing the fluid. A system can include an endoscope, a cannula system including a cannula extending through the endoscope, a fluid control system coupled to the cannula system, the fluid control system including a source of saline and a source of a freezing agent, and a fluid activator, wherein the fluid activator is configured to deliver at least one of the saline and the freezing agent through the cannula at a user's discretion.

Disclosed are an endoscope forceps elevator, an endoscope distal end and a duodenoscope system. The bottom of the endoscope forceps elevator is in communication with an instrument channel and the endoscope forceps elevator is provided with a hinge part configured to be hinged with an endoscope distal end base; a positioning groove adapted to an instrument to be positioned is provided at the top of the endoscope forceps elevator; and a cutting edge and a guide surface are provided at a side of the endoscope forceps elevator, and the guide surface is located between the positioning groove and the cutting edge. The cutting edge is movable in contact with the inner side surface of the distal end base so as to guide the instrument to be positioned in a first deflected and extended state onto the guide surface.