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Chemoembolization microspheres with microwave hyperthermia sensitization function, and preparation method and application thereof

A technique of chemoembolization and microwave sensitization, applied in the field of biomedicine, can solve the problems of residual tumor margin area and treatment failure, and achieves the effects of good biocompatibility, simple preparation method and good clinical application value.

Inactive Publication Date: 2017-05-31
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for large tumors with a diameter > 5 cm, due to the dielectric loss during microwave propagation, the tumor margins tend to remain, which leads to the failure of the entire treatment

Method used

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  • Chemoembolization microspheres with microwave hyperthermia sensitization function, and preparation method and application thereof
  • Chemoembolization microspheres with microwave hyperthermia sensitization function, and preparation method and application thereof
  • Chemoembolization microspheres with microwave hyperthermia sensitization function, and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0042] Example 1 Preparation of Porous Microspheres for Chemoembolization with Microwave Sensitization Function

[0043] Dissolve 10 mg of ammonium bicarbonate in 0.5 mL of deionized water to form an internal water phase; then dissolve 200 mg of polylactic-glycolic acid (molecular weight: 80,000, lactic acid: glycolic acid = 50:50) in 4 mL of dichloromethane to form an oil phase; The inner water phase was added to the oil phase, ultrasonically emulsified to obtain emulsion A; 500 mg of polyethylene glycol was dissolved in 50 ml of deionized water to obtain the outer water phase B; the obtained emulsion A was added to the outer water phase B, 1200r / Min mechanically stirred for 4h to obtain the porous microcapsules; sodium chloride (20mg / mL) and doxorubicin (1mg / mL) were dissolved in deionized water to form a solution C; the porous microspheres were soaked in solution C for 1h, The chemoembolization porous microspheres with a particle size of 20-70 μm and microwave sensitizatio...

Embodiment 2

[0044] Example 2 Preparation of Porous Microspheres for Chemoembolization with Microwave Sensitization Function

[0045] Dissolve 10 mg of ammonium bicarbonate in 0.5 mL of deionized water to form an internal water phase; then dissolve 200 mg of polylactic-glycolic acid (molecular weight: 50,000, lactic acid: glycolic acid = 10:90) in 4 mL of dichloromethane to form an oil phase; The inner water phase was added to the oil phase, ultrasonically emulsified to obtain emulsion A; 500mg polyethylene glycol was dissolved in 50ml deionized water to obtain the outer water phase B; the obtained emulsion A was added to the outer water phase B, 1400r / Min mechanically stirred for 3h to obtain the porous microcapsules; sodium chloride (10mg / mL) and doxorubicin (1mg / mL) were dissolved in deionized water to form solution C; the porous microspheres were soaked in solution C for 1h, The chemoembolization porous microspheres with a particle size of 20-70 μm and microwave sensitization function...

Embodiment 3

[0046] Example 3 Preparation of Porous Microspheres for Chemoembolization with Microwave Sensitization Function

[0047] Dissolve 10 mg of ammonium bicarbonate in 0.5 mL of deionized water to form an internal water phase; then dissolve 200 mg of polylactic-glycolic acid (molecular weight: 150,000, lactic acid: glycolic acid = 75:25) in 4 mL of dichloromethane to form an oil phase; The inner water phase was added to the oil phase, ultrasonically emulsified to obtain emulsion A; 1000mg polyethylene glycol was dissolved in 50ml deionized water to obtain the outer water phase B; the obtained emulsion A was added to the outer water phase B, 600r / Min mechanically stirred for 5h to obtain the porous microcapsules; sodium chloride (30mg / mL) and doxorubicin (1mg / mL) were dissolved in deionized water to form a solution C; the porous microspheres were soaked in solution C for 1h, Chemoembolization porous microspheres with a particle size of 600-700 μm and microwave sensitization functio...

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Abstract

The invention discloses application of chemoembolization porous microspheres with a microwave sensitization function in preparing a medicine or preparation for treating tumor. The adsorbate of the microspheres is inorganic salt and a chemotherapy medicine, the skeleton of the microspheres is poly(lactide-co-glycolide), the diameter of the microspheres is 20-700mu m, and the specific surface is greater than 10m<2> / g. The invention also provides a preparation method of the chemoembolization porous microspheres. The chemoembolization porous microspheres disclosed by the invention have good microwave sensitization heating and tumor blood vessel embolization function, exhibit regular spherical shapes, and have high porosity, narrow particle size distribution and controllable particle size; in addition, the chemoembolization microspheres with microwave sensitization prepared from the poly(lactide-co-glycolide) are applied to treatment of cancer for the first time, acquire an excellent tumor inhibiting effect and have good clinical application value.

Description

technical field [0001] The invention relates to the field of biomedicine. More specifically, it relates to a chemoembolization microsphere with microwave hyperthermia sensitization function, its preparation method and application. Background technique [0002] Primary liver cancer is a major clinical problem today. Conventional treatment methods include chemotherapy, radiotherapy, transhepatic arterial embolization, transhepatic arterial chemoembolization, and thermal ablation. These treatments can improve the living conditions of patients to some extent. Embolization usually requires multiple administrations, which will cause a series of problems such as organ failure, and it is less effective for tumor nodules with no capsule and less blood supply and surrounding satellite lesions and metastatic lesions. Often, investigators use chemoembolic agents to enhance therapeutic efficacy, for example, DOX-encapsulated Fe 3 o 4 After the nanoshell is wrapped into PVA, the drug ...

Claims

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Application Information

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IPC IPC(8): A61L24/04A61L24/02A61K41/00A61P35/00
CPCA61L24/046A61K41/0052A61L24/001A61L24/0015A61L24/0036A61L24/02A61L2300/416C08L67/04
Inventor 孟宪伟唐顺松任湘菱付长慧谭龙飞刘天龙
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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