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Multilevel porous/mesoporous organic silicon ball and preparation method thereof

A pore mesoporous and organosilicon technology, applied in the field of hierarchical porous mesoporous organosilicon spheres and their preparation, can solve the problems of difficult controllable release, restrict the application of hierarchical porous materials, etc., and achieve easy release and enhanced degradability. , the effect of improving efficiency

Active Publication Date: 2017-05-31
中国科学院上海硅酸盐研究所苏州研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage is that each dendritic polymer can generally only be loaded with one drug, and it is difficult to achieve sustained and controlled release, which greatly limits its application as a hierarchical porous material.

Method used

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  • Multilevel porous/mesoporous organic silicon ball and preparation method thereof
  • Multilevel porous/mesoporous organic silicon ball and preparation method thereof
  • Multilevel porous/mesoporous organic silicon ball and preparation method thereof

Examples

Experimental program
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preparation example Construction

[0040] Figure 12 Schematically shows the process flow diagram of the preparation method of the present invention, by Figure 12 It can be seen that the preparation method of the present invention includes, for example: sol-gel method and surfactant-directed method to synthesize SiO with controllable particle size 2 Nanoparticles; under hydrothermal conditions, silicon source and organosilicon source precursors are co-hydrolyzed and co-condensed to form a dendritic shell with adjustable thickness; after the product is separated (for example, with ethanol and water), it is washed multiple times; (for example, with hydrochloric acid extraction with ethanol at 75 degrees centigrade) to remove the surfactant and wash to obtain the product. Hereinafter, the method for preparing the hierarchically porous mesoporous silica nanoparticles will be described in detail.

[0041] First, using traditional sol-gel method, using surfactants as directing agents to synthesize monodisperse s...

Embodiment 1

[0062] Mix 45mL of deionized water and 5g of CTAC, and record it as solution A. Mix 9mL deionized water and 1gTEA, and record it as solution B. Mix 20g of liquid A and 0.8g of liquid B, and stir at a constant temperature of 95°C for 5 minutes; quickly add 1 mL of ethyl orthosilicate, and stir magnetically for 1 hour; mix 1 mL of ethyl orthosilicate and 2 mL of bis-[3-(triethoxy base silicon) propyl] tetrasulfide (BTES) after uniform mixing, quickly add the above solution, magnetic stirring for 4h, the product obtained after centrifugation of hierarchical porous mesoporous SiO 2 ball. Wash twice with ethanol, extract under the condition of hydrochloric acid ethanol for 6h (3 times) to remove the surfactant, wash twice with ethanol, and wash once with deionized water to obtain highly dispersed mesoporous SiO with hierarchical pores 2 particle.

[0063] The SiO obtained in this example 2 The transmission electron microscope image of the particle is shown in figure 1 As shown...

Embodiment 2

[0065] Mix 45mL of deionized water and 5g of CTAC, and record it as solution A. Mix 9mL deionized water and 1gTEA, and record it as solution B. Mix 20g of liquid A and 0.8g of liquid B, and stir at a constant temperature of 95°C for 5 minutes; quickly add 1 mL of ethyl orthosilicate, and stir magnetically for 1 hour; mix 1 mL of ethyl orthosilicate and 1.3 mL of bis-[3-(triethyl Oxysilane)propyl]tetrasulfide (BTES) was uniformly mixed, then quickly added the above solution, magnetically stirred for 4h; ] Tetrasulfide (BTES) was mixed evenly, and the above solution was added rapidly, and magnetic stirring was continued for 4h. Hierarchical mesoporous SiO was obtained after the product was centrifuged 2 ball. Wash twice with ethanol, extract under the condition of hydrochloric acid ethanol for 6h (3 times) to remove the surfactant, wash twice with ethanol, and wash once with deionized water to obtain highly dispersed mesoporous SiO with hierarchical pores 2 particle.

[006...

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Abstract

The invention relates to a multilevel porous / mesoporous organic silicon ball and a preparation method thereof, in particular to a multilevel porous / mesoporous silica nanoparticle. The silica nanoparticleis of a multilevel porous structure having large apertures and small apertures at the same time, and comprises a mesoporous silica ball and a dendritic organic silicon envelope layer, wherein the surface of the mesoporoussilica ball is wrapped by the dendritic organic silicon envelope laye, mesoporous aperture of the mesoporous silica ball is smaller than 2nm, and the mesoporous aperture of the dendritic organic silicon envelope layer is 4-9nm. The multilevel porous / mesoporous nanoparticle disclosed by the invention has the advantages of good dispersion, large specific surface area, large pore volume and uniform and adjustable aperture distribution.

Description

technical field [0001] The invention belongs to the technical field of microporous / mesoporous / macroporous molecular sieve nanomaterials, and relates to a multi-level porous mesoporous organic silicon ball and a preparation method thereof. Background technique [0002] According to the International Union of Pure and Applied Chemistry (IUPAC), materials with a porous structure are divided into microporous materials (pore diameter less than 2nm), mesoporous materials (pore diameter between 2nm and 50nm) and macroporous materials (pore diameter greater than 50nm). ). Since 1992 MCM-41 mesoporous SiO 2 Since molecular sieves were synthesized by Mobil scientists (Nature 1992,359,(6397),710-712.), mesoporous SiO 2 Due to its high specific surface area, large pore volume, and uniform pore structure, the material shows broad application prospects in the fields of chemical catalysis, medicine, and nanobiotechnology. Mesoporous SiO in various morphologies 2 Among materials, spheri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B33/18B82Y30/00B82Y40/00A61K47/04
CPCA61K47/02B82Y30/00B82Y40/00C01B33/18C01P2004/03C01P2004/04C01P2004/32C01P2004/64C01P2006/12C01P2006/14C01P2006/17
Inventor 孙丽君陈雨张晓华施剑林
Owner 中国科学院上海硅酸盐研究所苏州研究院
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