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Extraction method of aurantiamarin, and application of aurantiamarin to liver-protecting medicines

An extraction method and a technology for hesperidin, which are applied to the extraction method and its application in liver-protecting medicines, can solve the problems of being unsuitable for industrialized mass production, unsuitable for industrialized production, difficult to control temperature changes, and the like, and achieve extraction. The process is simple and feasible, the effect of avoiding calcium hydroxide precipitation and reducing the use of chemical substances

Active Publication Date: 2017-06-13
李潇
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the Soxhlet extraction method has the advantage of simple extraction process, but the progress of the experimental reaction is slow, multiple recrystallization extractions are required, and the solvent consumption is large
The alkali extraction and acid precipitation method has the advantages of saving economy and simple process, but its reaction time is long and it is easy to pollute the environment, so it is not suitable for industrial production
The microwave extraction method is less harmful to the environment, but the temperature change is not easy to control during the microwave extraction process, and it is not suitable for industrial mass production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The extraction method of hesperidin, it comprises the steps:

[0022] Get fresh orange peel without mildew, soak it in 50g / L sucrose aqueous solution for 12 hours, take it out, air-dry naturally, then crush it into 100 mesh orange peel powder, put it in the reaction kettle, control the pressure in the reaction kettle to be 1.2MPa, The temperature is 130°C, heat preservation and pressure holding for 5 minutes, then take it out, cool to room temperature, then add calcium hydroxide aqueous solution with a concentration of 0.6g / L and 0.08wt% cellulase accounting for orange peel powder (20000u / g), stirred at 200rpm for 5h, then stood still for 2h; heated up to 80°C, kept warm for 30min, lowered to room temperature, added hydrochloric acid to adjust the pH to 5.8, stood for 10h, filtered, collected the precipitate, and then added 10 times the weight 70 ℃ deionized water, stir to dissolve, put on the macroporous adsorption resin column, let it stand for 20min, then elute with ...

Embodiment 2

[0024] The extraction method of hesperidin, it comprises the steps:

[0025] Get fresh orange peel without mildew, soak it in 50g / L sucrose aqueous solution for 12 hours, take it out, air-dry it naturally, then crush it into 100 mesh orange peel powder, put it in the reaction kettle, control the pressure in the reaction kettle to be 1.6MPa, The temperature is 120°C, heat preservation and pressure holding for 3 minutes, then take it out, cool to room temperature, then add calcium hydroxide aqueous solution with a concentration of 0.6g / L accounting for 10-15 times the weight of orange peel powder and fibers accounting for 0.05wt% orange peel powder Sulfase (20000u / g), stirred at 200rpm for 5h, then stood still for 1h; heated up to 80°C, kept warm for 30min, cooled down to room temperature, added hydrochloric acid to adjust the pH to 5.8, stood still for 10h, filtered, collected the precipitate, and then added 10 Double the weight of deionized water at 70°C, stir to dissolve, put...

Embodiment 1-2

[0027] Example 1-2 extraction method of the present invention obtains product purity and yield detection:

[0028] Taking Gannan navel orange as an example, HPLC method measures the purity of hesperidin and the yield of hesperidin in the product; the calculation of the yield of hesperidin: the yield of hesperidin=((the quality of hesperidin product× Purity) / orange peel powder mass)×100%; the specific results are shown in Table 1:

[0029] Table 1

[0030] index Example 1 Example 2 Yield% 2.96 2.77 purity% 97.9 98.3

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PUM

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Abstract

The invention belongs to the technical field of plant extraction and discloses an extraction method of aurantiamarin. The extraction method of the aurantiamarin comprises the following steps: 1) soaking, air-drying and pulverizing; 2) performing heat-preserving and pressure-maintaining treatment; 3) performing calcium hydroxide and enzymolysis treatment; 4) heating, adjusting pH and collecting precipitates; and 5) performing adsorption, elution and evaporation drying. The extraction method provided by the invention is high in yield, and the obtained product can be used for preparing liver-protecting medicines.

Description

technical field [0001] The invention belongs to the technical field of plant extraction, and in particular relates to an extraction method of hesperidin and its application in liver-protecting medicines. Background technique [0002] Chinese aliases of hesperidin: hesperidin; dihydroflavone glycosides; Hesperidin is one of the main active ingredients of tangerine peel. The pure product is white needle-like crystals with the molecular formula C 28 h 34 o 15 . Studies have shown that hesperidin has physiological functions such as anti-oxidation, anti-allergy, antibacterial and anti-inflammatory, anti-virus and anti-cancer, prevention of cardiovascular diseases, lowering blood pressure, lowering low-density cholesterol, etc., and has high medicinal value. In addition, hesperidin is also used in the food and cosmetic industries as a natural oxidizing agent. [0003] At present, the sources of extracting hesperidin mainly include tangerine peel and orange peel. The extracti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/07C07H1/08A61K31/7048A61P1/16
CPCA61K31/7048A61K36/752C07H1/08C07H17/07
Inventor 李潇
Owner 李潇