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Preparation method and application of polystyrenesulfonic acid grafted graphene/polypyrrole composite hydrogel

A technology of polystyrene sulfonic acid and composite hydrogel, which is applied in the preparation of polystyrene sulfonic acid grafted graphene/polypyrrole composite hydrogel and the field of drug controlled release materials, which can solve the mechanical strength of conductive hydrogel Poor, poorly conductive components evenly distributed, no electrochemical activity, etc., to achieve improved solubility, good mechanical strength, and controlled release

Inactive Publication Date: 2019-05-03
WUHAN INSTITUTE OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This is mainly because common hydrogel materials are not electrochemically active and have little response to electrical stimulation; on the other hand, it is difficult to achieve a uniform distribution of conductive components in the hydrogel body for the currently reported conductive hydrogels. , and the mechanical strength of the obtained conductive hydrogel is poor, which limits its practical application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] 1) Disperse 0.5g of graphene oxide, 25mL of 2-bromoisobutyryl bromide, and 10mL of triethylamine in 50mL of chloroform, transfer them to an ice-water bath for 24 hours, centrifuge, wash, and dry to obtain group of graphene oxide;

[0021] 2) Disperse 0.02 g of graphene oxide containing initiator groups in 4 mL of deionized water, add 3 mg of cuprous chloride, 0.5 mg of cupric chloride, 0.15 mmol of bipyridine, and 1.2 mmol of styrene under an argon atmosphere. Sodium sulfonate, mixed evenly, reacted at 20°C for 6 hours, centrifuged, washed, and dried to obtain graphene oxide grafted with polystyrene sulfonic acid;

[0022] 3) Disperse 0.1 g of polystyrene sulfonic acid grafted graphene oxide in 30 mL of water, add 0.5 g of ascorbic acid, react at 90 ° C for 18 hours, centrifuge, wash and dry to obtain polystyrene sulfonic acid grafted graphite alkene;

[0023] 4) Disperse 0.05 g of polystyrene sulfonic acid grafted graphene in 10 mL of water, add 50 μL of pyrrole, sti...

Embodiment 2

[0025] 1) Disperse 0.6g graphene oxide, 30mL 2-bromoisobutyryl bromide, and 10mL triethylamine in 60mL N,N-dimethylformamide, transfer to an ice-water bath for 30 hours, centrifuge, wash, and dry Obtain the graphene oxide that contains initiating group afterward;

[0026] 2) Disperse 0.05 g of graphene oxide containing initiating groups in 6 mL of deionized water, add 4 mg of cuprous bromide, 0.6 mg of copper bromide, 0.2 mmol of bipyridyl, 1.5 mmol of benzene, respectively, under an argon atmosphere. Sodium ethylene sulfonate, reacted at 20°C for 8 hours, centrifuged, washed, and dried to obtain graphene oxide grafted with polystyrene sulfonic acid;

[0027] 3) Disperse 0.12 g of graphene oxide grafted with polystyrene sulfonic acid in 35 mL of water, add 0.6 g of tea polyphenols, react at 90 ° C for 20 hours, centrifuge, wash, and dry to obtain polystyrene sulfonic acid grafted dendritic graphene;

[0028] 4) Disperse 0.08 g of polystyrenesulfonic acid grafted graphene in ...

Embodiment 3

[0030] 1) Disperse 0.8g of graphene oxide, 40mL of 2-bromoisobutyryl bromide, and 18mL of triethylamine in 70mL of N,N-dimethylformamide, transfer to an ice-water bath to react for 24 hours, centrifuge, After washing and drying, graphene oxide containing initiator groups is obtained;

[0031] 2) Disperse 0.06 g of graphene oxide containing initiator groups in 8 mL of deionized water, add 5 mg of cuprous chloride, 1 mg of cupric chloride, 0.25 mmol of bipyridine, and 1.6 mmol of styrene under an argon atmosphere. Sodium sulfonate, reacted at 25°C for 6-12 hours, centrifuged, washed, and dried to obtain graphene oxide grafted with polystyrene sulfonic acid;

[0032] 3) Disperse 0.1 g of graphene oxide grafted with polystyrene sulfonic acid in 35 mL of water, add 0.7 g of ascorbic acid, react at 90 ° C for 18-24 hours, centrifuge, wash and dry to obtain polystyrene sulfonic acid grafted dendritic graphene;

[0033] 4) Disperse 0.1 g of polystyrenesulfonic acid grafted graphene ...

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Abstract

The invention relates to a preparation method of a polystyrolsulfon acid-grafted graphene / polypyrrole compound hydrogel. The method comprises the following steps: firstly, grafting polystyrolsulfon acid on the surface of graphene oxide; and then combining static synthesis of polypyrrole with compounding of the polystyrolsulfon acid-grafted graphene to obtain the target product, polystyrolsulfon acid-grafted graphene / polypyrrole compound hydrogel. In the compound hydrogel, various actions such as interaction of anions and cations, pi-pi conjugate action and hydrogen bonds exist between polystyrolsulfon acid-grafted graphene and polypyrrole, and the polystyrolsulfon acid-grafted graphene / polypyrrole compound hydrogel has good mechanical strength, and further is electroresponsive due to good electrochemical property of graphene and polypyrrole. Controlled release of a drug can be realized under electrical stimulation.

Description

technical field [0001] The invention relates to the technical field of functional materials, in particular to a method for preparing a polystyrenesulfonic acid grafted graphene / polypyrrole composite hydrogel, which is a controlled drug release material with electrical stimulation response. Background technique [0002] As people pay more and more attention to health, the research on the system with good drug controlled release performance is getting more and more in-depth. Through a good drug controlled release system, the drug can be released in time or space in the organism, and the drug can be maintained in the body to maintain the optimal concentration required for disease treatment, so as to avoid the high drug concentration during routine administration. Timely poisoning and treatment ineffectiveness when the drug concentration is low, to achieve the purpose of controllable treatment. Hydrogel materials are currently the most researched drug controlled release materia...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08L51/10C08L79/04C08F292/00C08G73/06A61K47/32A61K47/34
CPCA61K47/32A61K47/34C08F292/00C08G73/0611C08J3/075C08J2351/10C08J2379/04C08J2451/10C08J2479/04C08L51/10C08L79/04
Inventor 姚炜钦李亮喻湘华刘玉兰张桥
Owner WUHAN INSTITUTE OF TECHNOLOGY
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