Photosensitizer-loaded mesoporous organic silicon-gold nanometer triangular sheet composite material, and preparation method and application thereof
A technology of mesoporous silicone and composite materials, which is applied in photodynamic therapy, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., can solve the problems of low loading efficiency and high early release rate, and achieve loading High efficiency, good dispersibility, improved effect
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Embodiment 1
[0033] (1) Preparation and identification of aromatic mesoporous organic silica layer-wrapped gold nanotriangular sheets
[0034] (1) 25.4mM chloroauric acid solution and 0.1M sodium hydroxide solution are mixed according to the molar ratio of 1:1, and 100 μL of the resulting solution is added to 10 mL of a mixed aqueous solution containing 16mM cetyltrimethylammonium chloride and 0.75mM potassium iodide and shake gently; then add 100 μL 64mM ascorbic acid to the obtained solution, shake gently until the solution becomes colorless, then add 5 μL 0.1M sodium hydroxide, and mix quickly; stand at room temperature for 0.5-1h, then The product is centrifuged and washed at room temperature;
[0035](2) Transfer the product obtained in step (1) to water for dispersion, add 2 mL of the dispersion with an absorbance of 3.0 to 10 mL of a 20 mM cetyltrimethylammonium chloride aqueous solution, 0.1 mL of ammonia, and 2.9 mL of ethanol and mix In the solution, add 0.1mL of 10wt% 1,4-bis(t...
Embodiment 2
[0059] (1) Preparation of aromatic mesoporous organic silica layer-wrapped gold nanotriangular sheets
[0060] (1) 20mM chloroauric acid solution and 0.05M sodium hydroxide solution are mixed according to the molar ratio of 1:1, and 100 μL of the resulting solution is added to 10 mL of a mixed aqueous solution containing 10 mM cetyltrimethylammonium chloride and 0.5 mM potassium iodide , shake gently; then add 100μL 60mM ascorbic acid to the obtained solution, shake gently until the solution becomes colorless, then add 5μL 0.05M sodium hydroxide, mix quickly; stand at room temperature for 0.5-1h, and then dissolve the product Centrifuge and wash at room temperature;
[0061](2) Transfer the product obtained in step (1) to water for dispersion, add 2 mL of the dispersion with an absorbance of 2.0 to a mixed solution containing 10 mL of 10 mM cetyltrimethylammonium bromide aqueous solution, 0.1 mL of ammonia water, and 1 mL of ethanol , add 0.1mL of 5wt% 1,4-bis(triethoxysilyl)...
Embodiment 3
[0067] (1) Preparation of aromatic mesoporous organic silica layer-wrapped gold nanotriangular sheets
[0068] (1) 30mM chloroauric acid solution is mixed with 0.2M sodium hydroxide solution at a molar ratio of 1:1, and 100 μL of the resulting solution is added to 10 mL of a mixed aqueous solution containing 10 mM cetyltrimethylammonium chloride and 1 mM potassium iodide, Shake gently; then add 100μL 100mM ascorbic acid to the resulting solution, shake gently until the solution becomes colorless, then add 5μL 0.2M sodium hydroxide, mix quickly; let stand at room temperature for 0.5-1h, and then put the product in Centrifuge and wash at room temperature;
[0069] (2) Transfer the product obtained in step (1) to water for dispersion, add 2 mL of the dispersion with an absorbance of 4.0 to a mixed solution containing 10 mL of 10 mM cetyltrimethylammonium chloride aqueous solution, 0.1 mL of ammonia water, and 10 mL of ethanol 0.1 mL of 10 wt% 1,4-bis(triethoxysilyl)phenethyl alc...
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