Application of Amino Acid Chelated Calcium in Preparation of Percutaneous Absorption Preparation

Abstract

The present invention relates to applications of calcium amino acid chelate in preparation of a percutaneous absorption preparation. According to the present invention, the body is supplemented with calcium and amino acid through skin absorption, wherein the body can be preferentially supplemented with the required ion type calcium having physiological activity to the maximal degree through the percutaneous absorption manner, and specifically the calcium supplementing way through the percutaneous absorption can directly and rapidly supplement calcium to the epidermis system with no blood circulation system, such that the problem that the absorption rate of the orally-supplemented calcium is low, and the ion type calcium having physiological activity is insufficient due to the non-physiological-activity combined calcium firstly formed for bone forming after the absorption are solved; and the percutaneous absorption calcium amino acid chelate can be used for preparation of external application pharmaceutical preparations, medical and health materials, external application health product preparations, and cosmetics.

Description

technical field [0001] The invention relates to an amino acid chelated calcium for percutaneous absorption and treatment of skin diseases or systemic calcium supplementation, which has very excellent transdermal absorption effect, and is especially suitable for preparing pharmaceutical external preparations, medical and health external preparations, health care preparations, etc. External preparations and cosmetics, supplement various amino acids and calcium needed by the human body through percutaneous absorption, especially the physiologically active ionized calcium needed by the human body and the amino acids and calcium needed by the human epidermal system without blood circulation system Ions can be used to treat various skin diseases caused by skin calcium deficiency, repair after damaged skin barrier, and daily care and maintenance of skin. Background technique [0002] Calcium deficiency is a common problem in the human skin system, and it is relatively serious. Calc...

AI Technical Summary

Problems solved by technology

When the human body is in a state of calcium deficiency, the calcium supplemented by oral supplementation is preferentially used to supplement the combined calcium required by bones and teeth. At this time, the supplemented calcium has lost its physiological activity and cannot be supplemented or can only be supplemented in a very small amount. Ionized calcium, but this is insufficient for regulating the physiological activity of the body, so it is very difficult to maintain the balance and stability of the epidermal calcium ion by transporting calcium ions to the epidermis through blood circulation in the case of calcium deficiency in the human body

[0006] Oral calcium preparations are difficult to absorb, have a low absorption rate, and are affected by many and complicated factors, which are mainly caused by the complex environment of the gastrointestinal tract

Oral supplemented calcium is digested and absorbed through the gastrointestinal tract. The environment of the stomach is a strongly acidic environment with a pH value varying between 0.8 and 3.6. The environment of the small intestine is weakly alkaline and the pH value varies between 7.2 and 8.0. This change in the acid-base environment is unfavorable for the absorption of calcium ions. For example, calcium ions tend to form gelatinous calcium hydroxide precipitates in the alkaline intestinal environment, making it difficult for calcium ions to be absorbed by the body. At the same time, this gelatinous Thick matter can adhere to the intestinal wall, further affecting the absorption of other nutrients

In particular, oral calcium is easily polluted by anions in the gastrointestinal tract to form insoluble calcium, resulting in a significant reduction in the absorption rate of calcium ions, such as phytic acid, oxalic acid, alkaline phosphate, fat, and dietary fiber contained in the ingested food. Uronic acid residues, nucleotides, uric acid, etc. can react with calcium ions to form insoluble or insoluble calcium oxalate, calcium phytate, basic calcium phosphate, calcium urate, etc., which not only interfere with the absorption of calcium ions, but also Causing calcium to precipitate in tissues to become calcification foci, and to form stones in organs, affecting health

[0007] 2. There is no blood circulation system in the human epidermal system, and it is difficult to transport calcium ions with physiological activity.

[0009] 3. There is currently a lack of targeted calcium supplements for external use on the market

[0010] All kinds of calcium supplements currently on the market are oral preparations, including various calcium tablets and oral liquids, which are mainly developed for the special digestive system of the gastrointestinal tract. The pH value of the stomach is between 0.8 and 3.6, which belongs to In a strong acid environment, there are also various fungi, organic acids, and anions that pollute calcium ions and become insoluble substances that cannot be absorbed by the human body. The normal pH range of the human epidermis is between 5.2 and 6.5, which is a weakly acidic environment. Therefore, oral calcium preparations generally used for digestion and absorption through the gastrointestinal tract are difficult to absorb through the skin.

At the same time, the general oral calcium preparations mostly use inorganic calcium and ionic organic acid calcium such as calcium chloride, calcium carbonate, calcium lactate, calcium propionate, calcium citrate, calcium gluconate, etc. These calcium preparations are all in ionic state and have Calcium salts also have the problem of poor solubility. In the field of percutaneous absorption, insoluble compounds and ionic compounds are very difficult to absorb

[0011] At the same time, no scholars have studied the problem of percutaneous absorption of calcium, so it is very necessary to study calcium supplements that are conducive to percutaneous absorption, and it is also a very innovative research topic. The body supplements with physiologically active ionic calcium, especially the targeted calcium supplementation to the epidermis system that does not exist in the blood circulation system, and has high absorption efficiency, and is not affected by the special and complex environment of the gastrointestinal tract. The ions are easily polluted by anions, which leads to the problem of low absorption and utilization

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