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A taurine chelated calcium external preparation for rebuilding skin barrier homeostasis and its application

An external preparation, the technology of taurine, which is applied in the directions of skin care preparations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., can solve the problems such as difficult percutaneous absorption of calcium agents.

Active Publication Date: 2020-06-05
北京乳凝创新生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] In view of the importance of calcium to the skin and the above-mentioned problems in the percutaneous absorption of calcium, the present invention is to provide an external preparation containing taurine chelated calcium, which mainly consists of taurine chelated calcium, combined with a penetration-promoting The system together forms an external preparation containing taurine chelated calcium, which solves the problem that the existing calcium preparations are not easily absorbed through the skin, and greatly improves the absorption amount in the first 2h to 3h

Method used

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  • A taurine chelated calcium external preparation for rebuilding skin barrier homeostasis and its application
  • A taurine chelated calcium external preparation for rebuilding skin barrier homeostasis and its application
  • A taurine chelated calcium external preparation for rebuilding skin barrier homeostasis and its application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] 1. Preparation of chelated calcium taurine: In the experiment, taurine was used as a ligand, and calcium chloride, calcium carbonate, calcium phosphate, calcium hydrogen phosphate, calcium silicate, calcium lactate, calcium propionate, lemon One of calcium gluconate and calcium gluconate is used as a calcium source to provide central ion calcium to prepare amino acid chelated calcium for further experimental research, as follows:

[0037] 1) Weigh 45 g of taurine, dissolve it in a three-necked flask with 150 ml of deionized water, and heat it in a water bath to a constant temperature of 80°C until glutamic acid is completely dissolved;

[0038] 2) Weigh 20g of calcium lactate, completely dissolve in enough water, and adjust the pH to 7.8;

[0039] 3) Slowly add the calcium lactate solution prepared in 2) to the taurine solution in 1) drop by drop, stir gently while adding the calcium lactate solution, and keep a constant temperature during the stirring process;

[0040...

Embodiment 2

[0049] The impact of the content of taurine chelated calcium on the transdermal absorption effect: the transdermal absorption of different concentrations of taurine chelated calcium in the present invention is compared, and the preparation concentration is respectively 0.5%, 1%, 1.5%, 2%. Sulfonic acid chelated calcium solution, using mouse skin as a model, selected 0.9% sodium chloride aqueous solution as the receiving solution, and investigated the comparison of the above-mentioned taurine in the Franz intelligent transdermal diffusion cell without adding a penetration enhancer The transdermal properties of the chelated calcium aqueous solution within 6 hours, the results obtained are shown in the following table:

[0050] Table 1. Transdermal absorption of calcium taurine chelate at different concentrations

[0051]

[0052] As can be seen from the above experimental results, the higher the concentration of taurine chelated calcium, the better the percutaneous absorption...

Embodiment 3

[0054] The influence of the percutaneous absorption effect of taurine chelated calcium and other calcium agents: the comparison of transdermal effect between taurine chelated calcium and other different calcium agents in the present invention, preparation concentration is the same as 2% taurine respectively Acid chelated calcium solution, calcium chloride solution and calcium gluconate solution, using mouse skin as a model, choose 0.9% sodium chloride aqueous solution as the receiving solution, and investigate the conditions without adding a penetration enhancer in the Franz intelligent transdermal diffusion cell Next, the transdermal performance of the above solution within 6h, the results are as follows:

[0055] Table 2. Comparison of percutaneous absorption effects of calcium taurine chelate-calcium chloride-calcium gluconate

[0056] time / h Calcium Taurine Chelate calcium chloride calcium gluconate 0.25 4.8193 0.1837 0.6608 0.5 5.9813 0.3479 1...

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Abstract

The present invention discloses a calcium taurine chelate external application preparation for re-constructing skin barrier steady state, and applications thereof, wherein the external application preparation mainly comprises calcium taurine chelate, water, a penetrating promoter, and a preservative. According to the present invention, the calcium taurine chelate external application preparation mainly has the human body epidermal barrier system repair effect so as to achieve effects of skin protection, moisturizing, compacting, anti-allergy and the like, and can be adopted as cosmetic external application preparations, pharmaceutical external application preparations, health product external application preparations, medical and health external application preparations, and the like.

Description

technical field [0001] The invention relates to an external preparation containing chelated calcium taurine for treating skin diseases or calcium supplementation for the whole body system, which can be used to directly supplement calcium to the human skin system, solve the problems of skin calcium deficiency and calcium disorder, and has the function of repairing skin barrier, moisturizing, anti-inflammation, etc., and studied the penetration-enhancing system suitable for taurine chelated calcium preparations, and enhanced its transdermal absorption effect. It can be used in cosmetics, pharmaceuticals, health care products, medical and health and other fields. At the same time, a preparation method of the taurine chelated calcium external preparation is also provided. Background technique [0002] Calcium is very important to human skin. The American dermatology community first discovered the importance of calcium ions to the skin and formed a theoretical basis. It is belie...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K31/185A61K8/58A61K8/73A61K9/12A61K9/06A61P17/00A61P17/18A61P37/08A61P9/14A61P17/02A61P31/04A61P3/14A61Q19/02
CPCA61K8/345A61K8/49A61K8/58A61K8/73A61K8/97A61K9/0014A61K9/06A61K9/12A61K31/185A61K31/198A61K31/355A61K31/401A61K33/06A61K36/185A61K36/23A61K47/10A61K47/22A61K47/36A61K2800/524A61Q19/00A61Q19/02A61K2300/00
Inventor 侯玉庆刘彦宏陶几中马丹徐健梅侯天歌
Owner 北京乳凝创新生物科技有限公司
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