Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Exogenous hydrogen sulfide donor, and preparation and application thereof

A hydrogen sulfide donor, exogenous technology, applied in the field of medicine, can solve the problems of glutathione stimulation, anesthetic effect in the central nervous system, etc.

Inactive Publication Date: 2017-07-07
川北医学院
View PDF3 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of hydrogen sulfide in the body undergoes oxidative metabolism to form thiosulfate and sulfate for detoxification. During the metabolic process, glutathione may play a stimulating role; a small part can be metabolized by methylation to form less toxic methyl mercaptan and formazan. Thioether, but high concentrations of methyl mercaptan have an anesthetic effect on the central nervous system

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Exogenous hydrogen sulfide donor, and preparation and application thereof
  • Exogenous hydrogen sulfide donor, and preparation and application thereof
  • Exogenous hydrogen sulfide donor, and preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] An exogenous hydrogen sulfide donor with the following structure:

[0036]

Embodiment 2

[0038] The preparation method of compound I of the present invention comprises the following steps:

[0039] A, dissolving captopril in dichloromethane, adding acetyl chloride, then adjusting the pH value to 8-9, continuing the reaction to obtain an intermediate product;

[0040] B. Reacting the intermediate product with nortrithione in dichloromethane as a solvent to obtain compound I as the final product.

Embodiment 3

[0042] The preparation method of compound II of the present invention comprises the following steps:

[0043] A, proglumide is dissolved in the solvent dichloromethane, added successively nortrisulfide, DCC (dicyclohexylcarbodiimide), DMAP (4-dimethylaminopyridine), nitrogen protection reaction at room temperature;

[0044] B. After stopping the reaction, add NaOH solution dropwise to the reaction system until the pH value is 7, filter with suction, add water layer to the filtrate in a separatory funnel, add anhydrous sodium sulfate to the dichloromethane layer to remove residual water, spin Evaporated to dryness to obtain the final product.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides an exogenous hydrogen sulfide donor, and discloses a therapeutic action of an anethol trithione derivative used as the exogenous hydrogen sulfide donor on cardiovascular diseases. The exogenous hydrogen sulfide donor can release hydrogen sulfide, can promote the growth of an HUVEC (human umbilical vein endothelial cell) atherosclerosis cell model, has an antiatherosclerotic effect, and hopefully becomes a new target drug researched and developed by drugs with antiatherosclerotic effects.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an exogenous hydrogen sulfide donor and its preparation and application. Background technique [0002] Hydrogen Sulfide (H 2 S) is a colorless toxic gas with the smell of rotten eggs. It is the third gas signal with a wide range of physiological activities found in the body after nitric oxide (NO) and carbon monoxide (CO). molecular. As a new type of gas signal molecule, hydrogen sulfide is widely involved in the regulation of various systems of the human body, especially in the human cardiovascular system. In recent years, many studies have been conducted on the pathogenesis of hydrogen sulfide in atherosclerosis in vitro and in vivo, and hydrogen sulfide has become a new direction in the research of atherosclerosis. [0003] Endogenous hydrogen sulfide is produced by the metabolism of sulfur-containing amino acids in mammals. Hydrogen sulfide is mainly produced...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07D409/12C07D339/04A61K31/4025A61K31/381A61K33/04A61P9/10A61P9/00
CPCC07D409/12A61K31/381A61K31/4025A61K33/04C07D339/04
Inventor 周春阳陈钏李博袁斌欧学兰余刘勤梅雪杨春艳
Owner 川北医学院
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com