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Biochemical extraction technology of naringin, and use of extract in treatment of dermatitis

An extraction process and a technology for naringin, which are applied in the field of biochemical extraction, can solve problems such as being unsuitable for industrial production, low extraction efficiency, easy environmental pollution, etc., and achieve the effects of improving leaching rate, improving yield and purity, and improving extraction efficiency.

Active Publication Date: 2017-07-14
李潇
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The hot water extraction method has many impurities, low extraction efficiency, serious waste of water resources and other defects; the alkali extraction and acid precipitation method has the advantages of saving economy and simple process, but its reaction time is long and it is easy to pollute the environment, so it is not suitable for industrial production
Zhou Shilei, Chinese Journal of Agricultural Engineering, 2006, research on the ethanol extraction process of naringin from pomelo peel, using alcohol extraction, the extraction rate can reach 91%, but there are defects such as low purity and a large amount of ethanol consumption

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The biochemical extraction process of naringin comprises the following steps:

[0027] Get fresh and mildew-free pomelo peel, place it in 50 ° C and dry to a moisture content of less than 3 wt %, pulverize in a pulverizer, pass through a 100-mesh sieve, collect pomelo peel powder, and then add it to the same weight of 30g / L sucrose In the aqueous solution, stir at 300 rpm for 10 hours, then stand for 6 hours, dry at 50 °C, and place it in the reaction kettle. Add 5 times the weight of pomelo peel powder with a concentration of 0.4g / L calcium hydroxide aqueous solution and 0.07wt% cellulase (20000u / g) in pomelo peel powder, stir at 300rpm for 6h, and then stand for 30min; centrifuge to collect the precipitate , add twice the mass of 70% (v / v) ethanol to the precipitate, heat in a 60°C water bath, stir while heating for 30 min, let stand for 10 min, remove the precipitate by centrifugation, evaporate the liquid under reduced pressure to remove ethanol, and add twice volu...

Embodiment 2

[0029] The biochemical extraction process of naringin comprises the following steps:

[0030] Get fresh and mildew-free pomelo peel, place it in 50 ℃ and dry until moisture content is lower than 3 wt %, pulverize in a pulverizer, pass through a 100-mesh sieve, collect pomelo peel powder, and then add it to the same weight of 40g / L sucrose In the aqueous solution, stir at 500 rpm for 8 hours, then stand for 6 hours, dry at 50 ° C, and place it in the reaction kettle. Add 0.6g / L calcium hydroxide aqueous solution accounting for 5 times the weight of pomelo peel powder and 0.05wt% cellulase (20000u / g) accounting for pomelo peel powder, stir at 300rpm for 6h, and then stand for 30min; centrifuge to collect the precipitate , add twice the mass of 70% (v / v) ethanol to the precipitate, heat in a 60°C water bath, stir while heating for 30 min, let stand for 10 min, remove the precipitate by centrifugation, evaporate the liquid under reduced pressure to remove ethanol, and add twice v...

Embodiment 1-2

[0032] The extraction method of the embodiment of the present invention 1-2 obtains product purity and yield detection:

[0033] Taking Anjiang pomelo as an example, the HPLC method measures the purity of naringin and the yield of naringin in the product; the calculation of the yield of naringin: the yield of naringin=((quality of naringin product × purity ) / the quality of pomelo peel powder) × 100%; the specific results are shown in Table 1:

[0034] Table 1

[0035] index Example 1 Example 2 Yield% 7.19 6.82 purity% 96.6 97.1

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Abstract

The invention relates to the technical field of biochemical extraction, and discloses a biochemical extraction technology of naringin. The technology comprises the following steps: 1, drying and crushing; 2, sucrose processing; 3, high temperature and high pressure treatment; 4, alkali liquid and enzyme treatment; and 5, alcohol dissolving, temperature control and water extraction. The extraction technology is optimized through adopting multifactorial quadrature test, so the yield and the purity are improved; and the prepared product can effectively treat the dermatitis.

Description

technical field [0001] The invention relates to the technical field of biochemical extraction, in particular to a biochemical extraction process of naringin and the use of its extract in treating dermatitis. Background technique [0002] Naringin is a dihydroflavonoid compound. Since there is no conjugation between the A ring and the B ring, there is a strong ultraviolet absorption peak at 282nm, which makes naringin show a variety of biological activities and pharmacological effects. It has anti-inflammatory, anti-viral, anti-cancer, anti-mutation, anti-allergic, anti-ulcer, analgesic, and hypotensive activities, can lower blood cholesterol, reduce the formation of thrombus, improve local microcirculation and nutrient supply, and can be used for production and prevention of heart and brain. Vascular disease. Naringin is used as a natural pigment, flavor improver and bittering agent in the production of food and beverages, and can also be used as a new type of sweetener ...

Claims

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Application Information

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IPC IPC(8): C07H17/07C07H1/08A61P17/00
CPCC07H1/08C07H17/07
Inventor 李潇
Owner 李潇