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Dexamethasone nanogel and preparation method thereof

A dexamethasone and nanogel technology, applied in the field of medicine, can solve problems such as research lag, achieve the effects of improving solubility, avoiding liver first-pass effect, and improving transdermal efficiency

Inactive Publication Date: 2017-07-21
赵艳霞 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, at present, research on the basic theory and key technologies of transdermal drug delivery is still relatively lagging behind, especially the research on new carriers for transdermal drug delivery and skin pharmacokinetics, which has become a "bottleneck" restricting the development of transdermal drug delivery.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Take 0.9g of dexamethasone raw material, 20ml of castor oil, 20g of polyoxyethylene castor oil-propylene glycol mixed surfactant, 10g of carbomer 940, 50g of glycerin, 14g of triethanolamine, 40g of ethanol, 1g of paraben, and water supplement to 1000g.

[0025] Proceed according to the following method: add 0.9g of dexamethasone bulk drug to a stoppered test tube, add 20ml of castor oil and shake in a water bath at 37°C for 1 hour to completely dissolve it, then add 20g of polyoxyethylene castor oil-propylene glycol Mix surfactants, stir at a constant speed of 1300r / min for 30min, slowly add water dropwise by self-emulsification method, until the solution appears transparent or translucent, and form dexamethasone nanoemulsion; then weigh 10g of Carbomer 940, statically in water Place overnight to make it fully swell, then add 50g of glycerin, dropwise add 14g of triethanolamine, and stir to form a gel matrix; finally dissolve the dexamethasone nanoemulsion in 40g of et...

Embodiment 2

[0043] Take 1.5g of dexamethasone crude drug, 25ml of castor oil, 20g of polyoxyethylene castor oil-propylene glycol mixed surfactant, 12g of carbomer 940, 55g of glycerin, 16g of triethanolamine, 50g of ethanol, 1.5g of paraben, water supplement All to 1000g.

[0044] Proceed according to the following method: add 1.5g of dexamethasone raw material to a stoppered test tube, add 20ml of castor oil and shake in a water bath at 37°C for 1 hour to completely dissolve it, then add 20g of polyoxyethylene castor oil-propylene glycol Mix surfactants, stir at a constant speed of 1300r / min for 30min, slowly add water dropwise by self-emulsification method, until the solution appears transparent or translucent, and form dexamethasone nanoemulsion; then weigh 12g of Carbomer 940, statically in water Put overnight, make it fully swell, then add 55g glycerin, add dropwise triethanolamine 16g, stir . Slowly pour it into the gel matrix, seal it and place it in a refrigerator at 4°C overnigh...

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PUM

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Abstract

The invention relates to a dexamethasone nanogel and a preparation method thereof. 1000 g of dexamethasone nanogel is prepared from 0.9-1.5 g of crude dexamethasone drug, 20-25 ml of castor oil, 20 g of polyoxyethylated castor oil-propylene glycol mixed surfactant, 10-12 g of Carbomer, 50-55 g of glycerin, 14-16 g of triethanolamine, 40-50 g of ethyl alcohol, 1-1.5 g of nipagin and the balance water. A gel matrix is used as a microcarrier, its solubility can be improved, and the transdermal efficiency of the gel matrix can be improved by utilizing the transdermal characteristic of nano-emulsion; the gel has the characteristic of slow release and accordingly has a long-acting effect; the first-pass effect of the liver can be avoided, and meanwhile the direct harm of oral medication to the gastrointestinal tract is also decreased.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a dexamethasone nanogel and a preparation method thereof. Background technique [0002] Dexamethasone is an adrenocortical hormone that has various pharmacological effects such as anti-inflammation, anti-allergy, and immune suppression. Clinically, its external preparations are mainly used to treat neurodermatitis, contact dermatitis, seborrheic dermatitis, and chronic eczema. Bacterial and fungal infections can occur after long-term heavy use, and local acne, rosacea-like dermatitis, skin atrophy and telangiectasia can occur, and reactions such as itching, pigmentation, facial erythema, and wound healing disorders may occur. [0003] Transdermal drug delivery has become the third largest drug delivery method after oral administration and injection. Traditional methods to promote drug transdermal absorption include chemical penetration enhancement methods, such as the application of azone...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K47/44A61K47/32A61K31/573A61P17/00A61P25/00A61P17/08A61P17/10
CPCA61K9/0002A61K9/0014A61K9/06A61K31/573A61K47/32A61K47/44
Inventor 赵艳霞张婧
Owner 赵艳霞
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