Method for preparing atherosclerosis disease canine model
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- 北京希诺因生物科技有限公司
- Publication Date
- 2017-07-28
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Abstract
Description
technical field
[0001] The invention relates to a method for preparing an atherosclerotic disease model dog by gene knockout technology, in particular to a method for preparing an apolipoprotein E gene knockout disease model dog by using gene knockout technology. Background technique
[0002] Atherosclerosis (AS) is a multiple disease in the elderly caused by multiple factors such as genetics and environment, and is the main cause of cardiovascular and cerebrovascular diseases such as coronary heart disease, cerebral infarction, and peripheral vascular disease. Coronary atherosclerosis can cause angina pectoris, myocardial infarction, arrhythmia, and even sudden death if the stenosis of the artery reaches more than 75%.
[0003] The etiology of AS is complex, and its pathogenesis is related to a variety of pathogenic factors. It mostly occurs in the intima and subintima of large and medium-sized elastic vessels, muscular arterial walls, and is characterized by lipid depositi...