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Nano copper hydroxide electrode applied to glucose detection and preparation method thereof

A copper hydroxide and copper electrode technology, applied in measuring devices, material analysis by electromagnetic means, instruments, etc., can solve problems affecting electrode conductivity and detection stability, poor electrode stability, and unfavorable industrial production. The effect of high stability and reproducibility, short response time and low equipment requirements

Inactive Publication Date: 2017-08-01
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing problems are: the enzyme activity depends on environmental factors such as temperature and humidity; the electron transfer process is limited by the protein outer layer of the enzyme; the electrode stability is poor, the shelf life is short, and the preparation cost is high.
Most of the metals and metal compounds used are based on gold, silver, platinum, ruthenium and other precious metals, and the cost of carbon-based nanomaterials such as carbon nanotubes and graphene is also high
In addition, the current preparation of non-enzymatic glucose detection electrodes mainly adopts the method of sticking the above-mentioned nano-active units to the basic electrode, which not only affects the conductivity and detection stability of the electrode, but also is not conducive to large-scale industrial production.

Method used

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  • Nano copper hydroxide electrode applied to glucose detection and preparation method thereof
  • Nano copper hydroxide electrode applied to glucose detection and preparation method thereof
  • Nano copper hydroxide electrode applied to glucose detection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Preparation of Nano Copper Hydroxide Electrode

[0045] Straight Cu electrodes with a diameter of 3 mm were ground and polished with α-alumina with a particle size of 300 nm and 50 nm, respectively, and decontaminated by ultrasonication in ethanol and deionized water for 1 min, respectively. After being blown dry with nitrogen, it was placed in 15mL of 3M NaOH solution, used as the anode to be electrochemically oxidized, and a platinum sheet electrode was used as the cathode, with a constant current of 0.1mA and an oxidation time of 300s. After the reaction, rinse with deionized water and blow dry with nitrogen. Characterized by scanning electron microscopy ( figure 2 ), the electrode prepared in this embodiment consists of Cu electrode and nano Cu(OH) attached to its surface 2 Composition, Cu(OH) 2 It is a hexahedral crystal particle with a particle size of 10-150nm.

[0046] Glucose detection method

[0047] With the nano Cu(OH) prepared by this example 2 The e...

Embodiment 2

[0053] Preparation of Nano Copper Hydroxide Electrode

[0054] Straight Cu electrodes with a diameter of 3 mm were ground and polished with α-alumina with a particle size of 300 nm and 50 nm, respectively, and decontaminated by ultrasonication in ethanol and deionized water for 1 min, respectively. After blowing dry with nitrogen, place it in 15mL NaOH solution with a concentration of 1M, and use it as the anode to be electrochemically oxidized, and use the platinum sheet electrode as the cathode, the current is constant at 0.3mA, and the oxidation time is 300s. After the reaction, rinse with deionized water and blow dry with nitrogen. Characterized by scanning electron microscopy ( image 3 ), the electrode prepared in this embodiment consists of Cu electrode and nano Cu(OH) attached to its surface 2 Composition, Cu(OH) 2 It is a mixture of hexahedral crystal particles with a particle size of 10-150nm and a single-layer hollow tube with a diameter of 100-150nm and a length...

Embodiment 3

[0058] Preparation of Nano Copper Hydroxide Electrode

[0059] Straight Cu electrodes with a diameter of 3 mm were ground and polished with α-alumina with a particle size of 300 nm and 50 nm, respectively, and decontaminated by ultrasonication in ethanol and deionized water for 1 min, respectively. After blowing dry with nitrogen, place it in 15mL NaOH solution with a concentration of 5M, and use it as the anode to be electrochemically oxidized, with the platinum sheet electrode as the cathode, the current is constant at 0.5mA, and the oxidation time is 300s. After the reaction, rinse with deionized water and blow dry with nitrogen. Characterized by scanning electron microscopy ( Figure 4 ), the electrode prepared in this embodiment consists of Cu electrode and nano Cu(OH) attached to its surface 2 Composition, Cu(OH) 2 It is a single-layer hollow nanotube with a diameter of 100-150nm and a length of about 3-10μm.

[0060] Glucose detection method

[0061] With the nano ...

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Abstract

The invention relates to the technical field of inorganic nano materials and electrochemical transducers and specifically discloses a nano copper hydroxide electrode applied to glucose detection and a preparation method thereof. Aiming at the problems that fourth-generation non-enzymatic glucose detection electrodes are prepared from raw materials of higher-cost precious metal or carbon nanomaterials, an adhering and coating method for preparing electrodes affects electrode conducting efficiency and inspection stability, and the like, the invention provides the novel electrode which is prepared from nano copper hydroxide in situ growing on the surface of a copper-based electrode or material and other copper-coated conductive materials through simple electrochemical oxidation and the preparation method thereof. The electrode prepared through the method can serve as a work electrode to be directly applied to glucose detection based on a current-time curve of an electrochemical workstation and has short response time (less than 2s) to glucose, higher sensitivity (1000 to 2000mu A / cm<2> / mM) and a wider detection linear range (0.1 to 10mM); thus, the electrode disclosed by the invention has good application potential in the fields of blood sugar detection, fermenting process monitoring and the like.

Description

technical field [0001] The invention relates to the technical field of inorganic nano-materials and electrochemical sensors, in particular to a nano-copper hydroxide electrode and a preparation method thereof, and a glucose electrochemical detection method using the nano-copper hydroxide electrode as a working electrode. Background technique [0002] Glucose is an essential nutrient for the metabolism of organisms, but abnormal glucose concentration can cause serious diseases of organisms, such as diabetes, hypertension, renal failure, etc. Glucose detection is very important in the fields of life science and clinical medicine. The industrial application of glucose is also very extensive, and it is often used as a reducing agent in printing and dyeing leather, electroplating, mirror making and other industries. Rapid and accurate detection of glucose concentration in the microbial fermentation production process is also of great significance to the judgment and control of th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/327
CPCG01N27/3278
Inventor 卢滇楠芦琛璘任立伟李治鹏
Owner TSINGHUA UNIV
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