An indoleamine-2,3-dioxygenase inhibitor of nitrogen-containing alkylated and arylated sulfoximines
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI
- Publication Date
- 2020-10-09
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Abstract
Description
technical field
[0001] The invention belongs to the technical field of medicinal chemistry, and specifically relates to an IDO inhibitor containing nitrogen alkylation, arylation and acylation sulfoximine and a 1,2,5-oxadiazole structure and a preparation method thereof. Background technique
[0002] Indoleamine-2,3-dioxygenase (Indoleamine-2,3-dioxygenase, IDO) is a monomeric enzyme containing heme first discovered in cells by the Hayaishi group in 1967. The cDNA-encoded protein is composed of Composed of 403 amino acids, with a molecular weight of 45kDa, it is the rate-limiting enzyme for the catabolism of the tryptophan-kynurenine pathway, and is widely expressed in various mammalian tissues (Hayaishi O. et al Science, 1969, 164, 389-396). In the cells of tumor patients, IDO often plays an important physiological role in inducing immune tolerance in the tumor microenvironment, and its mediated tryptophan (Trp)-kynurenine (Kynurenine, Kyn) metabolic pathway participates i...