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Compound bone cement and preparation method thereof

A bone cement, liquid phase technology, applied in pharmaceutical formulations, pharmaceutical science, capsule delivery, etc., can solve problems such as implant loosening, inability to form tissue fusion, mechanical properties differences, etc., to accelerate repair, and is beneficial to cells and tissues. The effect of growing in

Active Publication Date: 2017-09-29
NINGBO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] 1. Excessive elastic modulus
The compressive modulus of normal vertebral cancellous bone in the human body is 50-800 MPa, while the compressive modulus of PMMA bone cement widely used in clinical practice is 1000-4000 MPa, which is much higher than that of human vertebral cancellous bone. PMMA bone cement and Significant differences in mechanical properties of human primary bone interface predispose to refracture of adjacent vertebral body segments
[0004] 2. Insufficient biological activity
PMMA is a biologically inert material that can hardly be degraded and absorbed in the body. The space it occupies not only hinders the formation and growth of new bone, but also cannot form a better tissue fusion with the original bone interface. Tissues are prone to fretting, and the fine debris generated by fretting will stimulate the body to produce an immune response, leading to local osteolysis at the implant site, which in turn will cause the implant to loosen or even fall off

Method used

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  • Compound bone cement and preparation method thereof
  • Compound bone cement and preparation method thereof
  • Compound bone cement and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The preparation method of the composite bone cement of embodiment one, comprises the following steps:

[0038] (1) Extraction of SIS slices:

[0039] Fresh pig small intestines were obtained from 6-month-old pigs with a weight of 100 kg, and the pig small intestines were washed repeatedly in clean water for 5 to 10 times. After washing, the pig small intestines were cut longitudinally, and then cut into multiple small sections with a length of 10 cm. Tear off the serosa and sarcolemma, then turn the mucosa part over, and scrape off the mucosal layer and muscularis mucosa;

[0040]First wash the SIS with PBS solution for 5-10 times, then quickly rinse the SIS twice with 70% alcohol, then soak the SIS in the PBS solution, shake it on a shaker at a speed of 30 rpm for two days, and replace the PBS every 12 hours during the shaking solution once; after shaking, soak the SIS in a mixture of methanol and chloroform at a volume ratio of 1:1 for 12 hours, then take out the SIS...

Embodiment 2

[0047] The preparation method of the composite bone cement of embodiment 2 may further comprise the steps:

[0048] (1) Extraction of SIS slices:

[0049] Fresh pig small intestines were obtained from 5-month-old pigs with a weight of 90 kg, and the pig small intestines were washed repeatedly in clean water for 5 to 10 times. After washing, the pig small intestines were cut longitudinally, and then cut into multiple sections with a length of 8 cm. Tear off the serosa and sarcolemma, then turn the mucosa part over, and scrape off the mucosal layer and muscularis mucosa;

[0050] First wash the SIS with PBS solution for 5-10 times, then quickly rinse the SIS twice with 70% alcohol, then soak the SIS in the PBS solution, shake it on a shaker at a speed of 30 rpm for two days, and replace the PBS every 12 hours during the shaking solution once; after shaking, soak the SIS in a mixture of methanol and chloroform at a volume ratio of 1:1 for 12 hours, then take out the SIS from the...

Embodiment 3

[0057] The preparation method of the composite bone cement of embodiment three, comprises the following steps:

[0058] (1) Extraction of SIS slices:

[0059] Fresh pig small intestines were obtained from 6-month-old pigs with a weight of 105 kg, and the pig small intestines were washed repeatedly in clean water for 5 to 10 times. After washing, the pig small intestines were cut longitudinally, and then cut into multiple small sections with a length of 12 cm. Tear off the serosa and sarcolemma, then turn the mucosa part over, and scrape off the mucosal layer and muscularis mucosa;

[0060] First wash the SIS with PBS solution for 5-10 times, then quickly rinse the SIS twice with 70% alcohol, then soak the SIS in the PBS solution, shake it on a shaker at a speed of 30 rpm for two days, and replace the PBS every 12 hours during the shaking solution once; after shaking, soak the SIS in a mixture of methanol and chloroform at a volume ratio of 1:1 for 12 hours, then take out the ...

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Abstract

The invention discloses compound bone cement. The compound bone cement consists of a solid phase and a liquid phase, wherein the solid phase comprises SIS (Small Intestinal Submucosa) particles and PMMA (Polymethyl Methacrylate) bone cement powder; in percentage by mass, the liquid phase consists of 96.0 to 99.8% of methyl methacrylate monomer, 0.6 to 1.5% of N,N-dimethyl-p-toluidine and 0.035 to 0.01% of hydroquinone, and the sum of the mass percentage of the components above is 100%; in the composition of the compound bone cement, mass of the PMMA bone cement powder is denoted as b grams, a volume of the liquid phase is denoted as V microliters, and a, b and V meet the following formulas: a ratio of a to b is greater than or equal to 0.05 and smaller than or equal to 0.4; (with reference to the specification). The compound bone cement disclosed by the invention has a suitable compression modulus when intensity of the bone cement is kept; moreover, the compound bone cement has a great pore size and adjustable mechanical performance, and is beneficial to ingrowth of cells and tissues after being applied to bone wound repair; meanwhile, bone formation conduction and bone formation inductivity of SIS can accelerate repair of a bone wound.

Description

technical field [0001] The invention relates to the technical field of bone injury repair and tissue engineering in biomedical engineering, in particular to a composite bone cement and a preparation method thereof. Background technique [0002] Polymethyl methacrylate (PMMA) bone cement is a bone adhesive filling material commonly used in clinical operations, and it has been used in clinical percutaneous vertebroplasty (PVP) for decades. usage history. Although its safety and efficacy have been widely recognized clinically, two key problems have attracted the attention of clinicians and researchers: [0003] 1. Too high modulus of elasticity. The compressive modulus of normal vertebral cancellous bone in the human body is 50-800 MPa, while the compressive modulus of PMMA bone cement widely used in clinical practice is 1000-4000 MPa, which is much higher than that of human vertebral cancellous bone. PMMA bone cement and Significant differences in mechanical properties of t...

Claims

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Application Information

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IPC IPC(8): A61L27/44A61L27/36A61L27/56
CPCA61L27/3629A61L27/3633A61L27/44A61L27/56A61L2300/30A61L2300/412A61L2300/622A61L2430/02C08L33/12
Inventor 赵基源张迟诸进晋李梅钟怡
Owner NINGBO UNIV
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