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Preparation method of visible sulfanilamide molecular engram detection membrane

A technology of molecular imprinting and sulfonamide, applied in chemical instruments and methods, other chemical processes, color/spectral characteristics measurement, etc., can solve the problems of cumbersome detection process and high cost, and achieve good optical characteristics, easy recycling, and easy operation Effect

Inactive Publication Date: 2017-09-29
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although humans have developed many effective and accurate detection methods for sulfonamides, such as high performance liquid chromatography, mass spectrometry, microextraction, and spectral analysis, these detection and analysis methods require the use of large-scale instruments and equipment, and the detection process is cumbersome and costly.

Method used

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  • Preparation method of visible sulfanilamide molecular engram detection membrane
  • Preparation method of visible sulfanilamide molecular engram detection membrane
  • Preparation method of visible sulfanilamide molecular engram detection membrane

Examples

Experimental program
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Effect test

Embodiment 1

[0037] (1) Prepare nanocrystalline cellulose (NCC), adjust the pH of NCC to 2.4 and the concentration to 3.8wt% by centrifugation and dialysis.

[0038] (2) Synthesize the imprinted precursor polymer of sulfonamide resin, and dissolve it with a mixed solvent of ethanol and water (15 / 85v / v%) to form a 40wt% mixed solution for use.

[0039] (3) After ultrasonically degassing the NCC suspension in step (1) for 20 min, draw 10 mL of NCC into a 25 mL round-bottomed flask, and add 300 μL of the resin imprinted precursor polymer solution in step (2) dropwise. The reaction was stirred at room temperature for 4h. Place it in a constant temperature water bath at 22°C to dry to form a film, that is, the sulfonamide molecularly imprinted composite film.

[0040](4) Place the membrane material in 16% sodium hydroxide eluting solution, and elute in a constant temperature water bath at 70° C. for 7-12 hours. After taking it out, first wash and soak it with a large amount of water, and then...

Embodiment 2

[0047] (1) Prepare nanocrystalline cellulose (NCC), adjust the pH of NCC to 2.4 and the concentration to 3.8wt% by centrifugation and dialysis.

[0048] (2) Synthesize the imprinted precursor polymer of sulfonamide resin, and dissolve it with a mixed solvent of ethanol and water (15 / 85v / v%) to form a 40wt% mixed solution for use.

[0049] (3) After ultrasonically degassing the NCC suspension in step (1) for 20 min, draw 10 mL of NCC into a 25 mL round-bottomed flask, and add 400 μL of the resin imprinted precursor polymer solution in step (2) dropwise. The reaction was stirred at room temperature for 4h. Place it in a constant temperature water bath at 22°C to dry to form a film, that is, the sulfonamide molecularly imprinted composite film.

[0050] (4) Place the membrane of (3) in a 16% sodium hydroxide elution solution, and elute in a constant temperature water bath at 70° C. for 7-12 hours. After taking it out, first wash and soak it with a large amount of water, and the...

Embodiment 3

[0054] (1) Prepare nanocrystalline cellulose (NCC), adjust the pH of NCC to 2.4 and the concentration to 3.8wt% by centrifugation and dialysis.

[0055] (2) Synthesize the imprinted precursor polymer of sulfonamide resin, and dissolve it with a mixed solvent of ethanol and water (15 / 85v / v%) to form a 40wt% mixed solution for use.

[0056] (3) After ultrasonically degassing the NCC suspension in step (1) for 20 min, pipette 10 mL into a 25 mL round-bottomed flask, and add 500 μL of the resin imprinted precursor polymer solution in step (2) dropwise. The reaction was stirred for 4h. Place it in a constant temperature water bath at 22°C to dry to form a film, that is, the sulfonamide molecularly imprinted composite film.

[0057] (4) Place the membrane material in 16% sodium hydroxide eluting solution, and elute in a constant temperature water bath at 70° C. for 7-12 hours. After taking it out, first wash and soak it with a large amount of water, and then use a mixed solution o...

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Abstract

The invention provides a preparation method of a visible sulfanilamide molecular engram detection membrane. The preparation method comprises the following steps: 1, preparing nano-crystalline cellulose; 2, synthesizing a sulfanilamide resin engram precursor polymer; 3, preparing a chiral nematic sulfanilamide molecular engram composite membrane; 4, preparing the visible sulfanilamide molecular engram detection membrane. In the preparation method, the liquid crystal cellulose being wide in source is taken as a detection substrate, and is subjected to room-temperature evaporation to assemble a regular nematic membrane structure; a molecular imprinting technology has a selective identification characteristic; a complex microcosmic signal is converted into a macroscopic visible signal to be applied to detection of pollution target molecules.

Description

technical field [0001] The invention relates to a molecularly imprinted detection membrane with a chiral nematic structure, in particular to a method combining liquid crystal cellulose and molecular imprinted technology to prepare an imprinted detection membrane for sulfonamide molecules, which belongs to the field of material preparation technology and detection technology. Background technique [0002] Sulfonamide antibacterial drugs are a second class of antibacterial drugs after antibiotics. It controls the reproduction of bacteria by inhibiting the synthesis of folic acid in the bacteria, so it is widely used in human medicine and animal feed additives. In addition, most of these drugs come from artificial synthesis, so the cost is low and the economic value is high. For a long time, sulfa drugs have played an important role in human production and life and social progress, such as anti-inflammatory and analgesic, anti-tumor, anti-cancer and so on. However, a large nu...

Claims

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Application Information

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IPC IPC(8): C08G8/10C08J9/26C08B15/02B01J20/26B01J20/30G01N21/29
Inventor 张福生郑旭东刘恩秀刘恩利喻龙宝闫永胜
Owner JIANGSU UNIV
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