Complexation system and complexation method for producing high-stability povidone iodine

Abstract

The invention provides a complexation system and a complexation method for producing high-stability povidone iodine. The complexation system comprises a rotary reaction kettle with a jacket, a vacuum feeding machine, a crushing machine, a vibrating sieve, a packaging machine and a hot water circulation control system. The vacuum feeding machine is positioned above the rotary reaction kettle with the jacket, the jacket of the rotary reaction kettle with the jacket is connected with the hot water circulation control system, and a discharge outlet is formed in the bottom of the rotary reaction kettle with the jacket and is sequentially connected with the crushing machine, the vibrating sieve and the packaging machine. The complexation method includes steps of adding auxiliaries into polyvinylpyrrolidone K30 and iodine to obtain mixtures, adding the mixtures into the reaction kettle and starting to stir the mixtures; controlling the reaction temperatures, keeping the heating speeds of 0.5-8 DEG C / h unchanged under the control and heating the mixtures by stages until the temperatures of the mixtures reach 48-85 DEG C. The polyvinylpyrrolidone K30 and the iodine are used as raw materials. The complexation system and the complexation method have the advantages that the heating rates and the reaction temperatures at different reaction stages can be accurately controlled by solid-phase povidone iodine complexation processes; the content of available iodine in the povidone iodine which is a product obtained by the aid of the complexation system and the complexation method is higher than 10.7%, the loss ratio is lower than 5.5%, and the povidone iodine is high in stability.

Description

technical field [0001] The invention belongs to the field of medical products, and in particular relates to a production method of a polymer containing vinylpyrrolidone. Background technique [0002] Povidone iodine (referred to as PVP-I) is an excellent antibacterial drug that can kill a variety of Gram-positive and negative bacteria, spores, fungi, Escherichia coli, Shigella, Foreskin Bacillus, Bacillus anthracis, and Rosary albicans Bacteria, Trichophyton gypsum, Giardia, Chlamydia, etc., the demand in the pharmaceutical market has doubled in recent years. Compound povidone-iodine has no toxic and side effects, and has a protective function on mucous membranes and skin. It will gradually replace alcohol in the application of disinfection, so that the market capacity of povidone-iodine will have a qualitative leap. With the development of society and the improvement of people's living standards, people pay more and more attention to health. Povidone-iodine is non-toxic an...

AI Technical Summary

Problems solved by technology

[0006] Its technical difficulty is: solvent (solution) method complexation process route is longer, and equipment investment is big, needs a large amount of organic solvents, and solvent recovery consumes a lot of energy, causes environmental pollution, post-processing time is long, and the utilization rate of iodine is low

Although the solid-phase complexation has a short process route, simple and safe operation, no solvent to participate in the reaction, and less impurities in the product, the reaction temperature is higher and the time is longer, and it is easy to cause polyvinylpyrrolidone to degrade and reduce the complexation ability of polyvinylpyrrolidone. , the content of available iodine decreases, the loss rate of available iodine in povidone-iodine aqueous solution increases, and the stability decreases

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