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A kind of astaxanthin micro-nano solid preparation

A solid preparation, astaxanthin technology, applied in skin care preparations, antitoxins, anti-inflammatory agents, etc., can solve the problems of single dosage form, low bioavailability, poor water dispersibility of natural astaxanthin, etc. And the effect of excellent storage stability, simple and mild process, good flow performance

Active Publication Date: 2021-01-01
RIZHAO POLYTECHNIC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a micro-nano solid preparation of astaxanthin, that is, a cold-water dispersible astaxanthin micro-nano solid steady-state preparation, so as to solve the problem of single form of natural astaxanthin dosage form, poor water dispersibility, poor stability and The problem of low bioavailability

Method used

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  • A kind of astaxanthin micro-nano solid preparation
  • A kind of astaxanthin micro-nano solid preparation
  • A kind of astaxanthin micro-nano solid preparation

Examples

Experimental program
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Effect test

Embodiment 1

[0041] 1) Low temperature treatment of natural astaxanthin extract

[0042] Weigh 1kg of natural astaxanthin extract, add 5L of absolute ethanol, fully stir and dissolve at 60°C, then slowly cool it down to 16°C at a cooling rate of 0.5°C / min, and keep it for 3 hours, filter Collect the solid precipitate.

[0043] 2) Preparation of natural astaxanthin low-energy self-microemulsification system

[0044] The solid precipitate obtained in step 1) and 0.3 g of tocopherol were uniformly dissolved in 3 L of ethyl acetate solution at 50° C. to obtain an astaxanthin-ethyl acetate oil phase system; then 10 L of astaxanthin was added to the oil phase system Tween 80 / absolute ethanol (2:1) mixed solution was uniformly stirred for 01h under the condition of 200r / min; after the stirring was completed, it was concentrated with a rotary evaporator until no solvent flowed out, and low-energy self-microbial protein rich in natural astaxanthin was obtained. emulsifying system.

[0045] 3) Pr...

Embodiment 2

[0052] 1) Low temperature treatment of natural astaxanthin extract

[0053] Weigh 1kg of natural astaxanthin extract, add 3L of methanol, fully stir and dissolve at 65°C, then slowly cool it down to 18°C ​​at a cooling rate of 0.8°C / min, keep it for 4 hours, and collect the solid by filtration Precipitate.

[0054] 2) Preparation of natural astaxanthin low-energy self-microemulsification system

[0055] The solid precipitate obtained in step 1) and 0.1 g of carnosic acid were uniformly dissolved in 3 L of ethyl acetate solution at 55° C. to obtain an oil phase system of astaxanthin-ethyl acetate; and then added to the oil phase system 10L of Tween 80 / absolute ethanol (2:1) mixed solution was uniformly stirred for 01h under the condition of 300r / min; after the stirring was completed, it was concentrated with a rotary evaporator until no solvent flowed out, and a low-energy self-contained product rich in natural astaxanthin was obtained. microemulsion system.

[0056] 3) Prep...

Embodiment 3

[0063] 1) Low temperature treatment of natural astaxanthin extract

[0064] Weigh 1kg of natural astaxanthin extract, add 4L of n-butanol, fully stir and dissolve at 60°C, then slowly cool it down to 14°C at a cooling rate of 1°C / min, and keep it for 2 hours, filter Collect the solid precipitate.

[0065] 2) Preparation of natural astaxanthin low-energy self-microemulsification system

[0066] Dissolve the solid precipitate obtained in step 1) and 0.5g of coenzyme Q in 3L of ethyl acetate solution at 60°C to obtain an astaxanthin-ethyl acetate oil phase system; then add 10L of Tween 80 / absolute ethanol (2:1) mixed solution was uniformly stirred for 01h under the condition of 200r / min; after the stirring was completed, it was concentrated with a rotary evaporator until no solvent flowed out, and low-energy self-microbial protein rich in natural astaxanthin was obtained. emulsifying system.

[0067] 3) Preparation of natural astaxanthin microencapsulation system

[0068] Mix...

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Abstract

The invention discloses a preparation method of an astaxanthin micro nanometer solid steady-state preparation capable of being dispersed through cold water. A natural astaxanthin extract is used as a raw material, through technologies of low-temperature treatment, low-energy self micro emulsification, microencapsulation, drying, granulation and embedding twice and the like, the astaxanthin micro nanometer solid steady-state preparation capable of being dispersed through cold water can be prepared. The prepared astaxanthin solid preparation powder disclosed by the invention is dried, good in flow property, and good in product processing and storing stability; and besides, the bioavailability of astaxanthin is significantly improved. The method is simple in preparation technology, mild in condition, and suitable for industrialized popularization and application. Through the adoption of the technique of the preparation method disclosed by the invention, the astaxanthin can be steadily applied in the field of aqueous-phase medium foods, solid medium foods, various premix food, daily chemical articles for use, medicines and the like, the application field of the astaxanthin is greatly widened, the pluralism of products is greatly widened, and the market potential is tremendous.

Description

technical field [0001] The invention belongs to the technical field of preparation of active substance preparations, in particular to an astaxanthin micro-nano solid preparation. Background technique [0002] Astaxanthin is the strongest natural antioxidant found in nature so far, its antioxidant capacity is 1000 times that of natural VE, 10 times that of β-carotene, 17 times that of grape seed oil, anthocyanin OPC 150 times that of coenzyme Q10, and 60 times that of coenzyme Q10. More and more research results show that astaxanthin has a variety of physiological activities, such as anti-aging, anti-tumor, prevention of cardiovascular and cerebrovascular diseases, liver protection, anti-diabetes, anti-inflammation, improvement of motor function, and astaxanthin It is the only carotenoid found so far that can penetrate the blood-brain and blood-retinal barriers, and can have a positive impact on the central nervous system and brain function. Therefore, adding astaxanthin to...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23L33/00A23P10/35A61K9/50A61K9/51A61K47/38A61K47/42A61K47/36A61K47/40A61K31/122A61P39/06A61P9/00A61P3/10A61P29/00A61P43/00A61K8/35A61Q19/00
CPCA61K8/35A61K9/5036A61K9/5052A61K9/5057A61K9/5161A61K31/122A61K47/38A61K2800/10A61Q19/00A23L33/00A23P10/35
Inventor 周庆新李玉环张冰
Owner RIZHAO POLYTECHNIC
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