Synthetic method of tributyrin and application of tributyrin in feeds

A technology of tributyrin and glycerin, which is applied in application, animal feed, additional food elements, etc., can solve problems such as unstable properties, difficulty in use, and sensitivity to butyric acid odor, and achieve increased feed intake and production operations Simple, less irritating effects on the digestive tract

Inactive Publication Date: 2017-11-24
ZHEJIANG ESIGMA BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Usually tributyrin is obtained by reacting butyryl chloride and glycerin (CN104045556A). Due to the characteristics of acid chloride, it is highly corrosive and difficult to transport and store. It is easy to produce acid mist when it encounters air, and its properties are extremely unstable. Difficult to use in
[0005] After the reaction of butyryl chloride and glycerin, a large amount of hydrochloric acid is produced, which is difficult to use and causes great damage to equipment
[0006] Although the activity of butyryl chloride is relatively high, the content of tributyrin prepared in the patent CN104045556A is difficult to reach more than 90% (w/w)
[0007] After the traditional reaction process, the product needs to be washed with water or alkaline water to remove excess hydrochloric acid and butyric acid, which will generate more waste water. Due to the sensitive smell of butyric acid, the generated w

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1: the synthesis of tributyrin

[0022] Put 92g of glycerin, 440g of butyric acid, and 9.8g of concentrated sulfuric acid into a 1000ml three-necked bottle equipped with a stirring and water-carrying device, stir and raise the temperature to 150°C, keep it warm, and use the water-carrying device to remove the generated water. The reaction time is 5 hours . After the reaction is over, replace the water-carrying device with a rectification tower filled with ceramics, keep the vacuum at 70-100pa, and collect the distillate at 170-175°C, which is tributyrin. %, the total yield was 97.78%. The former fraction and the substrate were collected and applied to the next batch of production.

Embodiment 2

[0023] Embodiment 2: the synthesis of tributyrin

[0024] Put 92g of glycerin, 440g of butyric acid, and 5g of concentrated sulfuric acid into a 1000ml three-necked bottle equipped with a stirring and water-carrying device, stir and heat up to 160°C, keep warm, and use the water-carrying device to remove the generated water. The reaction time is 3 hours. After the reaction is over, replace the water-carrying device with a rectification tower filled with glass, keep the vacuum at 70-100pa, and collect the distillate at 170-175°C, which is tributyrin. %, the total yield was 96.7%. The former fraction and the substrate were collected and applied to the next batch of production.

Embodiment 3

[0025] Example 3: Comparative experiment of tributyrin obtained by this patent method and other similar products (piglets)

[0026] The tributyrin obtained in this patent and the commonly used antibiotic nosiheptide are used as test drugs. Seven litters of healthy Du piglets with similar litters and parity were selected, with about 20 pigs per litter and an average weight of about 11 kg. According to the principle of random design, they were divided into 5 treatment groups and 2 control groups, with 2 columns in each group. The added components of tributyrin are: 50 mg, 100 mg, 500 mg, 1000 mg, 2000 mg of tributyrin per kilogram of feed. The positive control group used the basal diet supplemented with 5 mg / kg nosiheptide. The blank control group used the basal diet without adding any drugs.

[0027] The piglets in the experiment were group-fed, fed and watered ad libitum, routine piglet immunization procedures were carried out, feeding and management were carried out as usu...

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Abstract

The invention relates to a synthetic method of tributyrin and application of tributyrin in feeds. The synthetic method comprises the steps of directly synthesizing tributyrin from butyric acid and glycerin in the absence of a solvent at a high temperature by virtue of a liquid catalyst, separating tributyrin from unreacted raw materials by virtue of a rectifying column through a high vacuum distillation method, collecting a corresponding fraction, namely tributyrin, and detecting the content of a distillation with a content above 98%(w/w) by virtue of a high performance liquid chromatography for reuse. According to the application, tributyrin produced by virtue of a process disclosed by the invention is used for preparing a feed additive capable of promoting the growth of economic animals and increasing the feed conversion rate, and the actual adding amount of the additive is 1000ppm-2000ppm; and compared with tributyrin produced by virtue of other processes in the market, the adding amount can be reduced.

Description

technical field [0001] The invention belongs to the technical field of feed additives, and in particular relates to the preparation of tributyrin and its application in economical animal feeding. Background technique [0002] Glyceryl tributyrate (glyceryl tributyrate) is the chemical formula C 15 h 26 o 6 Short-chain fatty acid ester, CAS number: 60-01-5, molecular weight: 302.36, also known as glycerol tributyrate, white near oily liquid. Almost odorless, slightly fatty aroma. Soluble in ethanol, chloroform and ether, very difficult to dissolve in water (0.010%). The natural product is found in tallow. [0003] Tributylglycerides are not decomposed in gastric juice, and are slowly released into butyric acid and glycerol under the action of intestinal lipase. Butyric acid is a short-chain fatty acid, which is the main energy source of intestinal epithelial cells. It can significantly stimulate the proliferation of intestinal epithelial cells, increase the height of sm...

Claims

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Application Information

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IPC IPC(8): A23K20/158
CPCA23K20/158
Inventor 徐国华陈贵才
Owner ZHEJIANG ESIGMA BIOTECH CO LTD
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