Synthetic method of tributyrin and application of tributyrin in feeds

Abstract

The invention relates to a synthetic method of tributyrin and application of tributyrin in feeds. The synthetic method comprises the steps of directly synthesizing tributyrin from butyric acid and glycerin in the absence of a solvent at a high temperature by virtue of a liquid catalyst, separating tributyrin from unreacted raw materials by virtue of a rectifying column through a high vacuum distillation method, collecting a corresponding fraction, namely tributyrin, and detecting the content of a distillation with a content above 98%(w / w) by virtue of a high performance liquid chromatography for reuse. According to the application, tributyrin produced by virtue of a process disclosed by the invention is used for preparing a feed additive capable of promoting the growth of economic animals and increasing the feed conversion rate, and the actual adding amount of the additive is 1000ppm-2000ppm; and compared with tributyrin produced by virtue of other processes in the market, the adding amount can be reduced.

Description

technical field [0001] The invention belongs to the technical field of feed additives, and in particular relates to the preparation of tributyrin and its application in economical animal feeding. Background technique [0002] Glyceryl tributyrate (glyceryl tributyrate) is the chemical formula C 15 h 26 o 6 Short-chain fatty acid ester, CAS number: 60-01-5, molecular weight: 302.36, also known as glycerol tributyrate, white near oily liquid. Almost odorless, slightly fatty aroma. Soluble in ethanol, chloroform and ether, very difficult to dissolve in water (0.010%). The natural product is found in tallow. [0003] Tributylglycerides are not decomposed in gastric juice, and are slowly released into butyric acid and glycerol under the action of intestinal lipase. Butyric acid is a short-chain fatty acid, which is the main energy source of intestinal epithelial cells. It can significantly stimulate the proliferation of intestinal epithelial cells, increase the height of sm...

AI Technical Summary

Problems solved by technology

[0004] Usually tributyrin is obtained by reacting butyryl chloride and glycerin (CN104045556A). Due to the characteristics of acid chloride, it is highly corrosive and difficult to transport and store. It is easy to produce acid mist when it encounters air, and its properties are extremely unstable. Difficult to use in

[0005] After the reaction of butyryl chloride and glycerin, a large amount of hydrochloric acid is produced, which is difficult to use and causes great damage to equipment

[0006] Although the activity of butyryl chloride is relatively high, the content of tributyrin prepared in the patent CN104045556A is difficult to reach more than 90% (w / w)

[0007] After the traditional reaction process, the product needs to be washed with water or alkaline water to remove excess hydrochloric acid and butyric acid, which will generate more waste water. Due to the sensitive smell of butyric acid, the generated waste water is difficult to treat

[0008] Patent CN105801413A mentions the recovery of butyric acid by distillation, but due to the use of super strong solid acid as a catalyst, nitrogen protection is required in the process, and there is no rectification tower and vacuum distillation, so only butyric acid with a large difference in relative boiling point can be recovered. Acid, and the price of super acid is high, and it is difficult to store and use

[0009] Because the content of tributyrin produced by the existing technology is not high and there are many impurities, the residual butyric acid will have a strong smell, which will affect the animal's food attraction, and some residual catalysts will easily cause digestive tract reactions, so there is a patent (CN03128368) proposes that its addition amount in the feed needs to reach 5000-10000ppm to be effective, which undoubtedly increases the cost of addition