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A kind of method that reclaims phenylacetic acid from penicillin potassium lysate

A technology of penicillin potassium and lysate is applied in chemical instruments and methods, separation/purification of carboxylic acid compounds, preparation of carboxylate salts, etc., and can solve the problems of increasing environmental protection processing pressure and difficult viscous liquids.

Active Publication Date: 2020-10-27
INNER MONGOLIA CHANGSHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Using concentrated sulfuric acid to remove impurities and water multi-stage extraction can effectively separate phenylacetic acid from colored impurities, but in the process of separation, viscous liquid that is difficult to handle will be produced, which will increase the pressure of environmental protection treatment

Method used

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  • A kind of method that reclaims phenylacetic acid from penicillin potassium lysate
  • A kind of method that reclaims phenylacetic acid from penicillin potassium lysate
  • A kind of method that reclaims phenylacetic acid from penicillin potassium lysate

Examples

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Effect test

Embodiment 1

[0036] Embodiment 1 The method for reclaiming phenylacetic acid from penicillin potassium lysate according to the present invention

[0037] (1) Extraction of penicillin potassium lysate

[0038] Take 1L of the penicillin potassium lysate, measure its phenylacetic acid concentration to 27.69g / L by high performance liquid phase, lower the temperature to 5°C, and under stirring, add 500mL of the organic solvent toluene for extraction to the penicillin potassium lysate, add 30 % hydrochloric acid, adjust the pH of the feed liquid to 0.92, stir for 5 min, pour the mixed feed liquid into a separating funnel and let stand for phase separation to obtain 510 mL of an organic phase, which is for later use;

[0039] (2) Decolorization

[0040] 5.1g of activated carbon was added to the organic phase obtained in step (1), stirred for 30min, and filtered with suction to obtain the decolorized organic phase, which was used for subsequent use;

[0041] (3) Alkalization

[0042] To the dec...

Embodiment 2

[0053] Embodiment 2 The method for reclaiming phenylacetic acid from penicillin potassium lysate according to the present invention

[0054] (1) Extraction of penicillin potassium lysate

[0055] Take 1L of the penicillin potassium lysate, measure its phenylacetic acid concentration to be 27.69g / L by high performance liquid phase, lower the temperature to 15°C, and under stirring, add 500mL of the organic solvent dichloromethane for extraction to the penicillin potassium lysate, Add 30% hydrochloric acid, adjust the pH of the feed liquid to 0.8, stir for 10 min, pour the mixed feed liquid into a separatory funnel and let stand for phase separation to obtain 510 mL of an organic phase, which is for later use;

[0056] (2) Decolorization

[0057] To the organic phase obtained in step (1), add 5.1 g of activated carbon, stir for 60 min, and filter with suction to obtain the decolorized organic phase, which is for subsequent use;

[0058] (3) Alkalization

[0059] To the decolo...

Embodiment 3

[0070] Embodiment 3 The method for reclaiming phenylacetic acid from penicillin potassium lysate according to the present invention

[0071] (1) Extraction of penicillin potassium lysate

[0072] Take 1L of the penicillin potassium lysate, determine its phenylacetic acid concentration to be 27.69g / L by high performance liquid phase, lower the temperature to 15°C, and under stirring, add 500mL of the organic solvent MIBK for extraction to the penicillin potassium lysate, add 20 % hydrochloric acid, adjust the pH of the feed liquid to 1.5, stir for 10 min, pour the mixed feed liquid into a separatory funnel and let stand for phase separation to obtain 515 mL of an organic phase, which is for later use;

[0073] (2) Decolorization

[0074] 5.15g of activated carbon was added to the organic phase obtained in step (1), stirred for 30min, and filtered with suction to obtain the decolorized organic phase for subsequent use;

[0075] (3) Alkalization

[0076] To the decolorized org...

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Abstract

The invention relates to a method for recovering phenylacetic acid from a benzylpenicillin potassium lysis solution and belongs to the technical field of pharmacy. The method for recovering the phenylacetic acid from the benzylpenicillin potassium lysis solution comprises the steps that the benzylpenicillin potassium lysis solution is extracted through an organic solvent; an organic phase is decolored through an activated carbon and alkalized through a sodium hydroxide solution; and the obtained alkalized water phase is oxidized with hydrogen peroxide and decolored with activated carbon so that a sodium phenylacetate aqueous solution with a light color can be obtained, the sodium phenylacetate aqueous solution is acidized and crystallized through concentrated sulfuric acid, washed with cold water and dried, and phenylacetic acid is obtained. The obtained phenylacetic acid product is high in quality, no waste difficult to deal with is generated in the recovering process, and the method is suitable for large-scale application.

Description

technical field [0001] The invention relates to a method for recovering phenylacetic acid, in particular to a method for recovering phenylacetic acid from penicillin potassium lysate, and belongs to the technical field of pharmacy. Background technique [0002] Penicillin potassium is cleaved into 6-APA and phenylacetic acid by the action of penicillin G acylase. Phenylacetic acid is a by-product of 6-APA production and a precursor to penicillin fermentation. How to effectively recover the phenylacetic acid produced during the production of 6-APA and apply it to the fermentation of penicillin is a problem faced by penicillin production enterprises. A large amount of research has been carried out in China on recovering phenylacetic acid from 6-APA production wastewater, and three main recovery processes are used, which will be described below through specific documentation. [0003] Chinese patent (application number: 201010519414.7) reported that the phenylacetic acid wast...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C51/02C07C57/32
CPCC07C51/02C07C51/412C07C51/42C07C57/32
Inventor 陈英新眭谦陈顺记郭建明王继明韩贺东
Owner INNER MONGOLIA CHANGSHENG PHARMA
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