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Antithrombotic metallic material

A metal material and anti-thrombosis technology, which is applied in the direction of anti-coagulation treatment, packaging item types, special packaging items, etc., can solve the problems of blood recognition as foreign matter and easy formation of thrombus, and achieve the effect of maintaining low hemolytic toxicity

Active Publication Date: 2017-11-28
TORAY IND INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In particular, with regard to medical devices made of metal materials such as stents, they are easily recognized as foreign objects by blood and easily form blood clots.

Method used

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  • Antithrombotic metallic material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1）

[0157] As the metal material, a plate material of SUS304 (length: 1 cm, width 0.5 cm) was used. SUS304 was ultrasonically washed with water, acetone, and methanol in sequence, and then vacuum-dried. The washed SUS304 was immersed in 1 mM compound A (the following general formula (I)) ethanol solution at 37°C overnight, then washed with ethanol and water, and then vacuum-dried to covalently bond compound A to SUS304. surface (1st coating process).

[0158] [chemical formula 9]

[0159]

[0160] Next, SUS304 was immersed in an aqueous solution of 0.5% by weight of DMT-MM (manufactured by Wako Pure Chemical Industries, Ltd.) and 5.0% by weight of PEI (LUPASOL (registered trademark) P; manufactured by BASF Corporation) as a part of the coating material. Reaction was performed at 30° C. for 2 hours, and PEI was covalently bonded to compound A by condensation reaction (second coating step). The aqueous solution after the reaction was removed and washed with distilled water.

...

Embodiment 2）

[0166] Except changing compound A to compound B (the following general formula (II)), the same operation as Example 1 was performed, and the 1st coating process and the 2nd coating process were implemented. In addition, the same operation as in Example 1 was performed, and after the quaternization step was implemented using ethyl bromide, the third coating step was implemented.

[0167] [chemical formula 10]

[0168]

[0169] Here, SUS304 subjected to the second coating process with PEI (LUPASOL (registered trademark) P; manufactured by BASF Corporation) was used as sample 4, and PEI (average molecular weight about 70,000; manufactured by Wako Pure Chemical Industries, Ltd.) was subjected to the second coating step. The SUS304 of the 2-coating process was set as sample 5.

[0170] For each sample, the ratio of the amount of nitrogen atoms and sulfur atoms on the surface measured by X-ray photoelectron spectroscopy (XPS) to the amount of all atoms, and the anti-Xa Determin...

Embodiment 3）

[0172] The same operation as in Example 1 was carried out, and after the first coating step and the second coating step were implemented, SUS304 was immersed in an aqueous solution of 0.5% by weight DMT-MM and 0.5% by weight PAA (manufactured by Wako Pure Chemical Industries, Ltd.). Reaction was performed at 30° C. for 2 hours (first additional step). The aqueous solution after the reaction was removed, and washed with an aqueous sodium carbonate solution and distilled water.

[0173] Furthermore, SUS304 was immersed in the aqueous solution of 0.5weight% DMT-MM and 5.0weight%PEI, and it reacted at 30 degreeC for 2 hours (2nd additional process). The aqueous solution after the reaction was removed and washed with distilled water. The same operation as in Example 1 was performed, and after the quaternization step was implemented using ethyl bromide, the third coating step was implemented.

[0174] Here, SUS304 subjected to the first coating process with compound A and the seco...

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Abstract

The present invention addresses the problem of providing an antithrombotic metallic material which has improved safety against low hemolytic toxicity and can exhibit high antithrombotic properties sustainably. The present invention provides an antithrombotic metallic material comprising a metallic material of which the surface is coated with a coating material, wherein the coating material comprises a phosphonic acid derivative or a catechol derivative, a polymer containing, as a constituent monomer, a compound selected from the group consisting of an alkyleneimine, vinylamine, allylamine, lysine, protamine and diallyl dimethyl ammonium chloride and a sulfur-atom-containing compound having an anionic anticoagulant activity, the polymer is covalently bonded to the phosphonic acid derivative or the catechol derivative, the phosphonic acid derivative or the catechol derivative is bonded to the metallic material through a phosphonic acid group or a catechol group contained in the derivative, and the ratio of the amount of nitrogen atoms to the total amount of all of atoms is 4.0 to 13.0% by atom number when the surface of the antithrombotic metallic material is measured by an X-ray photoelectron spectroscopy (XPS).

Description

technical field [0001] The present invention relates to antithrombotic metallic materials. Background technique [0002] For medical devices (medical instruments and medical devices) that come into contact with blood (more specifically, artificial kidneys, artificial lungs, artificial blood vessels, artificial valves, stents, stent grafts, catheters, free thrombus capture devices, blood vessels Endoscopes, sutures, blood circuits, tubes, cannula, blood bags, syringes, etc.) require high antithrombotic properties in order to prevent functional decline due to blood coagulation. [0003] In particular, medical devices made of metal materials such as stents are easily recognized as foreign objects by blood and easily form thrombus. [0004] In order to impart antithrombotic properties to metal materials, a method of coating or chemically bonding heparin or a heparin derivative as an anticoagulant to the surface of the metal material has been reported. As a method for coating o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/00A61L33/00A61L33/10
CPCA61L31/10A61L33/0029A61L33/0041A61L33/0023A61L31/00A61L33/00A61L33/0011A61L33/0035A61L33/0082A61L33/022A61L33/04A61L33/06A61L33/064A61L33/068A61L2300/42A61L2300/606A61L2400/02A61L2400/18
Inventor 门胁功治藤田雅规阪口有佳棚桥一裕
Owner TORAY IND INC
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