Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation process of ammonium ferric citrate

A kind of ferric ammonium citrate, the technology of preparation process, applied in the direction of carboxylate preparation, carboxylate preparation, organic compound preparation and other directions, can solve the problems of insoluble matter, dehydration difficulty, foaming and the like, and achieve the improvement of product yield, The effect of avoiding dehydration difficulty and improving solubility

Pending Publication Date: 2017-12-01
郑州瑞普生物工程有限公司
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The purpose of the present invention is to: choose a new process route, use ferrous sulfate as raw material to prepare ferric ammonium citrate, solve the insoluble matter and foaming problems in the iron powder preparation process; avoid dehydration difficulties caused by ferric hydroxide colloidal precipitation , the problem of high process cost

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation process of ammonium ferric citrate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Step 1: 100g of ferrous sulfate is added to 500mL of water, stirred and dissolved to obtain ferrous sulfate aqueous solution,

[0026] Step 2: Slowly add 150mL aqueous solution containing 50g of sodium carbonate into the ferrous sulfate solution, fully react for 1-2h at room temperature, and react to generate ferrous carbonate.

[0027] Step 3: Suction filtration, wash the precipitate with water until no sulfate ion is detected, add water and stir evenly, then add 100g of citric acid to the above precipitate, stir for 1-2h,

[0028] Step 4: Add hydrogen peroxide to oxidize until there is no ferrous ion, then add ammonia water or pass through ammonia gas, stir the reaction to adjust the pH to 6-8, and then react for 0.5-1h,

[0029] Step 5: Heating and concentrating to 1 / 2 of the volume, cooling, adding ammonia water or introducing ammonia gas.

[0030] Step 6: drying at 130-150°C or spray-drying at 190-200°C to obtain ferric ammonium citrate product.

Embodiment 2

[0032] Step 1: 150g of ferrous sulfate is added to 800mL of water, stirred and dissolved to obtain ferrous sulfate aqueous solution,

[0033] Step 2: Then slowly add 150mL aqueous solution containing 50g of sodium carbonate into the ferrous sulfate solution, fully react for 1-2h at room temperature, and react to generate ferrous carbonate.

[0034] Step 3: Suction filtration, wash the precipitate with water until no sulfate ion is detected, add water and stir evenly, then add 150g citric acid to the above precipitate, stir for 1-2h,

[0035] Step 4: Add hydrogen peroxide to oxidize until there is no ferrous ion, add ammonia water or pass through ammonia gas, stir the reaction to adjust the pH to 6-8, and then react for 0.5-1h,

[0036] Step 5: Heating and concentrating to 1 / 3 of the volume, cooling, adding ammonia water or introducing ammonia gas.

[0037] Step 6: drying at 130-150°C or spray-drying at 190-200°C to obtain ferric ammonium citrate product.

Embodiment 3

[0039] Step 1: 110g of ferrous sulfate is added to 600mL of water, stirred and dissolved to obtain an aqueous solution of ferrous sulfate,

[0040] Step 2: Then slowly add 150mL aqueous solution containing 50g of sodium carbonate into the ferrous sulfate solution, fully react for 1-2h at room temperature, and react to generate ferrous carbonate.

[0041] Step 3: Suction filtration, wash the precipitate with water until no sulfate ion is detected, add water and stir evenly, then add 110g of citric acid to the above precipitate, stir for 1-2h,

[0042] Step 4: Add hydrogen peroxide to oxidize until there is no ferrous ion, add ammonia water or pass through ammonia gas, stir the reaction to adjust the pH to 6-8, and then react for 0.5-1h,

[0043] Step 5: Heating and concentrating to 1 / 4 of the volume, cooling, adding ammonia water or introducing ammonia gas.

[0044] Step 6: drying at 130-150°C or spray-drying at 190-200°C to obtain ferric ammonium citrate product.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preparation process of ammonium ferric citrate. According to the process, ferrous sulfate is used as raw materials for preparing ammonium ferric citrate. The process comprises the following concrete steps of 1, adding ferrous sulfate into water; then, performing stirring dissolution; 2, slowly adding a sodium carbonate water solution into a ferrous sulfate solution; performing sufficient reaction for 1 to 2h at the room temperature; 3, performing extraction filtering; washing precipitates by water until no sulfate ion is detected; adding water; performing uniform stirring; then, adding citric acid into the precipitates; performing stirring reaction for 1 to 2h; 4, adding oxydol for oxidization; then, adding ammonia water or introducing ammonia gas; performing stirring reaction; regulating pH to 6 to 8; then, performing reaction for 0.5 to 1h; 5, performing heating concentration and cooling; adding ammonia water in a supplementary way; 6, performing drying at 130 to 150 DEG C or performing spray drying at 190 to 200 DEG C; obtaining the ammonium ferric citrate product.

Description

technical field [0001] The invention relates to the technical field of ferric ammonium citrate preparation, in particular to a preparation process of ferric ammonium citrate. Background technique [0002] Ferric ammonium citrate, also known as ferric ammonium citrate, is a compound salt of ferric citrate and ammonium citrate. Solvent, aqueous solution is neutral. Ferric ammonium citrate is widely used in medicine, food, feed, and industry. It is a good nutritional enhancer and can be used as a blood tonic to treat iron-deficiency anemia; Reducibility, it can be used for meteorological analysis and making blueprints; ammonium ferric citrate is also an important component of some nutrient media. In addition, using ammonium ferric citrate as a raw material can improve the performance of some anticancer drugs. [0003] The preparation process of ferric ammonium citrate mainly includes two production processes of iron powder and ferrous sulfate as raw materials. [0004] The p...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07C51/41C07C59/265C01G49/00
CPCC01G49/00C07C51/412C07C59/265
Inventor 张要华宋文超班莹莹
Owner 郑州瑞普生物工程有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com