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Surface-modified silicon-based hydrogel molecularly imprinted kaempferol polymer and preparation method thereof

A technology of molecular imprinting and surface modification, applied in chemical instruments and methods, other chemical processes, etc., can solve problems such as no research or report on hydrogel kaempferol.

Active Publication Date: 2017-12-01
JINLING INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is no research or report on hydrogel-modified surface molecularly imprinted kaempferol

Method used

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  • Surface-modified silicon-based hydrogel molecularly imprinted kaempferol polymer and preparation method thereof
  • Surface-modified silicon-based hydrogel molecularly imprinted kaempferol polymer and preparation method thereof
  • Surface-modified silicon-based hydrogel molecularly imprinted kaempferol polymer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Bis-3-methacryloxypropylated tetramethyldisiloxane (DMS), N,N-dimethylacrylamide (DMA) and 3-methacryloxytri(trimethyl Siloxy)silane (TRIS) was mixed in 3ml at a volume ratio of 1:1:3. Add a 1:10 volume ratio mixture of ethylene glycol dimethacrylate (EGDMA) and ethanol. Pass 10min N 2 Afterwards, 6 mg of diphenylphosphine oxide was added as a photoinitiator, and stirred for 3 min. Then UV light was irradiated for 40min to carry out polymerization.

[0070] Weigh 1g of activated silicon hydrogel into 30ml of toluene, add 0.5ml of coupling agent γ-(2,3-epoxypropoxy)propyltrimethoxysilane, blow nitrogen, and reflux at 100°C 8h. The reactant was placed in a Petri dish and air-dried at room temperature for 20 h and then vacuum-dried for 2 h. The dried silicon hydrogel was placed in 0.02 mol / L dilute hydrochloric acid solution, refluxed and reacted for 1 h at 50° C. under nitrogen gas, then washed with acetone and dried in vacuum. The product was placed in a mixed solu...

Embodiment 2

[0074] Bis-3-methacryloxypropylated tetramethyldisiloxane (DMS), N,N-dimethylacrylamide (DMA) and 3-methacryloxytri(trimethyl Siloxy)silane (TRIS) was mixed in 3ml at a volume ratio of 4:1:2. Add a 1:20 volume ratio mixture of ethylene glycol dimethacrylate (EGDMA) and ethanol. Pass 15min N 2 Afterwards, 8 mg of diphenylphosphine oxide was added as a photoinitiator, and stirred for 5 min. Then UV light was irradiated for 50min to carry out polymerization.

[0075] Weigh 2.12g of activated silicon hydrogel and place it in 50ml of toluene, add 0.85ml of coupling agent γ-(2,3-epoxypropoxy)propyltrimethoxysilane, pass N 2 , 110 ° C under the conditions of reflux for 10h. The reactant was air-dried at room temperature for 24 h in a petri dish, and then vacuum-dried for 4 h. Place the dried silicon hydrogel in 0.05mol / L dilute hydrochloric acid solution, pass N 2 Reflux at 55°C for 2 h, then wash with acetone and dry in vacuo. The product was placed in a mixed solution of tri...

Embodiment 3

[0079]Bis-3-methacryloxypropylated tetramethyldisiloxane (DMS), N,N-dimethylacrylamide (DMA) and 3-methacryloxytri(trimethyl Siloxy)silane (TRIS) was mixed in 3ml at a volume ratio of 1:3:5. Add a 1:30 volume ratio mixture of ethylene glycol dimethacrylate (EGDMA) and ethanol. Pass 20min N 2 Afterwards, 10 mg of diphenylphosphine oxide was added as a photoinitiator, and stirred for 7 minutes. Then UV light was irradiated for 60min to carry out polymerization.

[0080] Weigh 3g of activated silicon hydrogel and place it in 70ml of toluene, add 1ml of coupling agent γ-(2,3-epoxypropoxy)propyltrimethoxysilane, pass N 2 , Refluxed for 12h at 120°C. The reactants were air-dried at room temperature for 30 h in a petri dish, and then vacuum-dried for 8 h. Place the dried silicon hydrogel in 0.07mol / L dilute hydrochloric acid solution, pass N 2 Reflux at 60°C for 4 h, then wash with acetone and dry in vacuo. The product was placed in a mixed solution of triethylamine, maleic an...

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Abstract

The invention discloses a surface-modified silicon-based hydrogel molecularly imprinted kaempferol polymer and a preparation method thereof. The preparation method comprises the following steps: (1) with 3-methacryloyloxy tri(trimethylsiloxy)silane and bis-3-methacryloxypropylated tetramethyldisiloxane as raw materials, adding a cross-linking agent and an initiator, and synthesizing silicon-based hydrogel by virtue of an ultraviolet radiation method; (2) modifying the silicon-based hydrogel by virtue of surface grafting; and (3) synthesizing a molecularly imprinted polymer capable of selectively recognizing kaempferol from maleic anhydride modified silicon-based hydrogel by taking kaempferol as a template molecule, acrylamide as a functional monomer and N,N'-methylene bisacrylamide as a cross-linking agent. The prepared polymer is subjected to performance characterization and a selective recognition experiment. The preparation method is simple in operation and mild in reaction, the obtained polymer has good mechanical properties, relatively good translucency, good selective recognition effect to kaempferol and wide application prospects in the field of contact lenses.

Description

technical field [0001] The invention relates to the field of hydrogel and biomedicine, in particular to a surface-modified silicon-based hydrogel molecular imprinted kaempferol polymer and a preparation method thereof. Background technique [0002] With the development of society and the improvement of living standards, people's understanding of eye physiology is getting deeper and deeper, and the requirements for contact lenses are getting higher and higher, which also puts forward higher requirements for contact lens materials. Due to the defects of the material properties of traditional contact lenses, such as poor oxygen permeability and low water content, it causes eye discomfort and even eye diseases. For this reason, it is particularly important to synthesize new silicon-based hydrogel contact lens materials. [0003] Silicone-based hydrogel is a kind of organic polymer material with hydrophilic properties. It has a "honeycomb" structure. The silicone phase and the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/09C08J9/28C08F230/08C08F220/54C08F220/20C08F2/48C08F8/46B01J20/26B01J20/30C08L43/04
CPCC08F2/48C08F8/46C08F230/08C08F290/00C08J3/095C08J9/28C08J2343/04C08F220/54C08F220/20
Inventor 郝凌云张小娟冯苏丽蔡文斌王心怡刘彦雷赵雪李书亚
Owner JINLING INST OF TECH