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Surface enhanced Raman scattering substrate material and preparation method thereof

A surface-enhanced Raman and substrate material technology, applied in Raman scattering, material analysis, material excitation analysis, etc., can solve the problems of SERS repeatability and stability, difficult to achieve gas detection, difficult quantitative detection, etc., to achieve SERS Enhanced, highly reproducible, and easy-to-operate effects

Inactive Publication Date: 2017-12-05
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

However, the uniformity of the SERS substrate and the uniform distribution of the detected substance on the substrate will affect the repeatability and stability of SERS, making it difficult to achieve quantitative detection.
The signal of SERS attenuates sharply with the distance between the detection object and the hot spot, so the analyte must be adsorbed on the SERS hot spot, so it is difficult for SERS to detect gases

Method used

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  • Surface enhanced Raman scattering substrate material and preparation method thereof
  • Surface enhanced Raman scattering substrate material and preparation method thereof
  • Surface enhanced Raman scattering substrate material and preparation method thereof

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preparation example Construction

[0074] Here, according to an embodiment of the present invention, the present invention further provides a method for preparing a functionalized modified SERS substrate, comprising the following steps:

[0075] (1) Preparation of a uniform SERS substrate: Mix the core-shell structure material with a solvent to form a suspension, drop the suspension onto a clean square monocrystalline silicon wafer of known size, and slowly evaporate the solvent in its solvent atmosphere , to get the SERS substrate.

[0076] Among them, the solvent is water or ethanol; the concentration of the suspension can be 20mg / mL~50mg / mL; the size of the silicon chip can be adjusted according to different detection requirements, and according to the embodiment of the present invention, the size of the silicon chip can be 0.2cm*0.2cm ~1cm*1cm, specifically 0.3cm*0.3cm, 0.5cm*0.5cm or 0.9cm*0.9cm.

[0077] (2) Functional modification of the SERS substrate: soak the SERS substrate in an ethanol solution of ...

Embodiment 1

[0098] The steps of preparing the SERS base material using the method of the embodiment of the present invention are as follows:

[0099] (1) Preparation and TEM characterization of monodisperse nanoparticles:

[0100] Dissolve 100mg of chloroauric acid in a mixed solvent of 10mL oleylamine and 10mL hexane, dissolve 43.5mg of borane-tert-butyl complex in a mixed solvent of 1mL oleylamine and 1mL hexane, and then quickly inject In chloroauric acid solution, react at 10°C for 1h. After the reaction was completed, 40 mL of ethanol was added and centrifuged to obtain monodisperse gold nanoparticles.

[0101] The morphology and particle size distribution of the gold nanoparticles obtained above were analyzed and detected, and the particle size distribution results are shown in 3, as shown in the figure, the left figure is a TEM picture of gold nanoparticles, and the right figure is a particle size distribution figure. The results show that, The nanoparticles are evenly distribute...

Embodiment 2

[0114] The steps of preparing the SERS base material using the method of the embodiment of the present invention are as follows:

[0115] (1) Preparation and TEM characterization of monodisperse nanoparticles:

[0116] Dissolve 100mg of chloroauric acid in a mixed solvent of 10mL oleylamine and 10mL hexane, dissolve 21.7mg of borane-tert-butyl complex in a mixed solvent of 2mL oleylamine and 2mL hexane, and then quickly inject In chloroauric acid solution, react at 18°C ​​for 1h. After the reaction, 40 mL of ethanol was added and centrifuged to obtain monodisperse nanoparticles. The TEM characterization results of the nanoparticles were consistent with those in Example 1.

[0117] (2) Preparation and TEM characterization of superparticles:

[0118] Re-dissolve the gold nanoparticles in chloroform to obtain 10 mg / mL gold nanoparticle colloid, dissolve 20 mg of dodecyltrimethylammonium bromide in 1 mL of ultrapure water, and mix the gold nanoparticle colloid with ten Aqueous ...

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Abstract

The invention discloses a surface enhanced Raman scattering substrate material and a preparation method thereof. The surface enhanced Raman scattering substrate material comprises a superparticle structure and a metal-organic frameworks layer, wherein the superparticle structure is composed of gold nanoparticles, part of which is surface-bound to functionally modified molecules; and the metal-organic frameworks layer is formed on at least part of the surface of the superparticle structure. The surface enhanced Raman scattering substrate material can be used for quantitative detection of lung cancer respiratory marker.

Description

technical field [0001] The invention relates to a surface-enhanced Raman scattering base material and a method for preparing the surface-enhanced Raman scattering base material. Background technique [0002] Volatile organic gases (VOCs) in human body exhalation reflect the metabolic level of corresponding tissue cells, and the expression level of VOCs in lung cancer patients is quite different from that of ordinary people. Therefore, the detection of VOCs in exhaled matter is expected to become a new, rapid and non-destructive screening method for early lung cancer, which will buy valuable time for cancer treatment and relieve patients' pain. Aldehyde molecules are an important class of molecules in VOCs. They can be used as respiratory markers to judge the metabolism of tissue cells according to their content, and then realize the early diagnosis of cancer. [0003] At present, VOCs detection and analysis are mainly carried out by solid-phase microextraction combined with...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65B22F1/00
CPCG01N21/658B22F1/102
Inventor 王铁乔学志
Owner INST OF CHEM CHINESE ACAD OF SCI
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