Pharmaceutical preparation used for iron-deficiency anemia and preparation method thereof
A technology for iron-deficiency anemia and pharmaceutical preparations, which is applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve the problems of unsatisfactory effects of iron-deficiency anemia, loss of active ingredients of polysaccharides, and increase of raw material costs, etc. , to achieve the effect of simple and feasible preparation method, high polysaccharide extraction efficiency, and shortened extraction time
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Embodiment 1
[0023] A preparation method for a pharmaceutical preparation for iron deficiency anemia, comprising the steps of:
[0024] 1) Take 100g of seaweed, crush it, put it into an ultrasonic extraction tank, add twice the weight of 70% (v / v) ethanol, control the temperature at 50-60°C, and extract with ultrasonic frequency 50KHz for 90-120min, filter and collect the filtrate , vacuum rotary evaporation to recover ethanol, then concentrate the raffinate under reduced pressure to a paste of 1.2g / ml, add 10 times the weight of water, stir evenly, then add an equal volume of 5% trichloroacetic acid, let stand for 6h, Collect the supernatant by centrifugation, add absolute ethanol to make the alcohol content reach 80%, let it stand overnight, wash the precipitate with absolute ethanol, and dry to obtain 10.3g of ultraviolet extract with a sugar content of 94.1%;
[0025] 2) Take 20g fungus, add 16 times the weight of water, soak for 30 minutes, heat to a slight boil for 2 hours, filter, a...
Embodiment 2
[0035] Effects of extraction process on effective substances of polysaccharides from Lycium barbarum and Jujube:
[0036] Taking Comparative Example 1 as an example, the process of Lycium barbarum and Jujube was respectively used in Comparative Example 1, and the content of polysaccharide was determined by the phenol-sulfuric acid method, and the influence of different processes on the yield of polysaccharide was detected; see Table 1 for details:
[0037] Table 1
[0038]
Embodiment 3
[0040] Toxicity test:
[0041] In this experiment, healthy SD rats were used, and the dose gradients of the pharmaceutical preparations prepared in Example 1 were administered orally at 1ml / kg and 5ml / kg, administered continuously for 45 days, and observed during the administration of the rats and 1 week after drug withdrawal. Animal growth status, activity diet, hematology, blood biochemistry, organ tissue structure and urine routine were not significantly affected, indicating that the clinical medication is safe and reliable.
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