A class of gadolinium-containing magnetic resonance imaging contrast agent and its preparation and application

A magnetic resonance imaging and contrast agent technology, which is applied in the field of gadolinium-containing magnetic resonance contrast agents, can solve problems such as poor thermodynamic stability and dynamic stability, gadolinium ion deposition, and nephrogenic systemic fibrosis in patients, so as to improve thermodynamic and kinetic stability, damage reduction, and enhanced lipophilic performance
CN107456583BActive Publication Date: 2020-05-29阿克索南京生物科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
阿克索南京生物科技有限公司
Publication Date
2020-05-29

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Abstract

The invention relates to a gadolinium-containing magnetic resonance imaging contrast agent and preparation and application thereof. The gadolinium-containing magnetic resonance imaging contrast agent is prepared by connecting phenyl groups to DOTA-NHNH2 groups and then chelating the paramagnetic metal ion of Gd+. The structural formula of the gadolinium-containing magnetic resonance imaging contrast agent is shown as the formula. The gadolinium-containing magnetic resonance imaging contrast agent is a phenyl substituent group-containing non-ionic magnetic resonance imaging contrast agent, improves the lipophilic performance by introducing the hydrophobic groups and meanwhile achieves selectivity of liver imaging.
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Description

technical field

[0001] The invention relates to the field of magnetic resonance imaging, in particular to a class of gadolinium-containing magnetic resonance contrast agent and its preparation and application. Background technique

[0002] Since Lauterbur realized Magnetic Resonance Imaging (MRI) for the first time in 1973, MRI technology has been highly valued by the scientific community for its non-invasive, painless, precise positioning and image display similar to anatomical maps. The medical field continues to expand and has become one of the most important medical imaging equipment in imaging examinations. However, the resolution of magnetic resonance imaging cannot meet the clinical requirements in some cases. In order to enhance the imaging effect, it is necessary to give magnetic resonance contrast agent before the magnetic resonance examination. According to literature reports, in current clinical MRI, more than 35% of MRI examinations require the use of contrast ...

Claims

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