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Production method of medical polyurethane antibacterial nano-silver coating

A technology of polyurethane and nano-silver, which is applied in coatings, catheters, etc., can solve the problems of antibacterial effects of materials, low bonding strength between nano-silver coatings and carrier materials, etc., and achieve obvious antibacterial properties, fast preparation speed, and high content.

Inactive Publication Date: 2018-01-16
NANCHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the bonding strength between the nano-silver coating and the carrier material directly obtained by chemical reduction deposition on the surface of the medical catheter is not high, and the antibacterial property of the material will also be affected.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] (1) Raw material and formula.

[0019] Polydopamine coating: medical polyurethane, 0.015mol / L Tris-HCl buffer (mainly tris, dilute hydrochloric acid, distilled aqueous solution, pH=8.5), dopamine hydrochloride (98%).

[0020] Nano silver coating: silver nitrate, ammonia water, glucose, absolute ethanol.

[0021] (2) Preparation steps.

[0022] Preparation of polydopamine coating on polyurethane surface: a. Weigh 102.1mg of tris-hydroxymethylaminomethane and dissolve it in 100ml of distilled water, add it dropwise to adjust its pH to 8.5, and prepare Tris-HCl buffer solution; b. Weigh 800mg of dopamine solution Stir in Tris-HCl buffer solution for 30 minutes at room temperature in the dark, add medical polyurethane, and react in the dark for 24 hours in an aerobic environment at room temperature, take it out, wash it with distilled water, and dry it in a vacuum oven at 60°C for 10 hours to prepare Polyurethane with polydopamine coating was obtained.

[0023] P...

Embodiment 2

[0025] (1) Raw material and formula.

[0026] Polydopamine coating: medical polyurethane, 0.02mol / L Tris-HCl buffer (mainly tris, dilute hydrochloric acid, distilled aqueous solution, pH=8.5), dopamine hydrochloride (98%).

[0027] Nano silver coating: silver nitrate, ammonia water, glucose, absolute ethanol.

[0028] (2) Preparation steps.

[0029] Preparation of polydopamine coating on polyurethane surface: a. Weigh 242.8mg of tris-hydroxymethylaminomethane and dissolve it in 100ml of distilled water, add dropwise to adjust its pH to 8.5, and prepare Tris-HCl buffer solution; b. Weigh 900mg of dopamine solution Stir in Tris-HCl buffer solution at 25°C for 30 minutes in the dark, add medical polyurethane, and react in the dark for 24 hours in an aerobic environment at 25°C, take it out, wash it with distilled water and dry it in a vacuum oven at 60°C for 10 hours , to prepare polyurethane with polydopamine coating.

[0030] Preparation of nano-silver coating: a. We...

Embodiment 3

[0032] (1) Raw material and formula.

[0033] Polydopamine coating: medical polyurethane, 0.025mol / L Tris-HCl buffer solution (mainly tris, dilute hydrochloric acid, distilled aqueous solution, pH=8.5), dopamine hydrochloride (98%).

[0034] Nano silver coating: silver nitrate, ammonia water, glucose, absolute ethanol.

[0035] (2) Preparation steps.

[0036] The preparation of polydopamine coating on the surface of polyurethane: a. Weigh 303.5mg trishydroxymethylaminomethane and dissolve it in 100ml of distilled water, add it dropwise to adjust its pH to 8.5, and prepare Tris-HCl buffer solution; b. Weigh 900mg dopamine solution Stir in Tris-HCl buffer solution at 25°C for 30 minutes in the dark, add medical polyurethane, and react in the dark for 24 hours in an aerobic environment at 25°C, take it out, wash it with distilled water and dry it in a vacuum oven at 60°C for 10 hours , to prepare polyurethane with polydopamine coating.

[0037] Preparation of nano-silv...

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PUM

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Abstract

A production method of a medical polyurethane antibacterial nano-silver coating comprises the following steps: (1) dissolving dopamine in Tris-HCl buffer solution with the concentration being 0.015-0.025 mol / L and the pH value being 7.5-9, and carrying out a reaction at 20-30 DEG C in a dark environment for 25-35 min, wherein a dosage ratio of the dopamine to H2O is (800-1000) mg : 100 ml; (2) adding polyurethane to a solution obtained in the step (1), carrying out a reaction at 20-30 DEG C in a dark environment, taking out the polyurethane, flushing the polyurethane with plasma water, and drying the flushed polyurethan in a vacuum drying box; and (3) adding polyurethan obtained in step (2) into a silver ammonia solution, reducing silver nitrate with glucose as a reducing agent, and carrying out ultrasonic vibration cleaning to obtain the antibacterial polyurethane. The polyurethane nano-silver coating has the advantages of obvious antibacterial property, high content, high density, good dispersivity, no shedding and fast production speed.

Description

technical field [0001] The invention belongs to the technical field of biological material surface engineering and obtains an antibacterial medical polyurethane material with a stable nano-silver coating. Background technique [0002] Catheters with internal stents are widely used and indispensable medical devices in clinical treatment of urology, but catheter-associated urinary tract infection (CAUTI) caused by indwelling internal stents is a common nosocomial infection in clinical practice. Medical polyurethane is widely used in the production of medical inner stent catheters. [0003] The antibacterial properties of silver have long been known and utilized, such as wrapping skin wounds with gauze woven with silver threads, and using silver utensils to store food to prevent corruption. But in the 1930s, people discovered antibiotics and began to use them in large quantities, and silver-based antibacterial materials were ignored. In recent years, due to the abuse of antib...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/10A61L29/08A61L29/06A61L29/14A61L29/16
Inventor 李小兵仇宏宇温学花莫静文彭钟有钟慧萍
Owner NANCHANG UNIV
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