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Stomach tonifying sustained release capsule and preparation method thereof

A technology for sustained-release capsules and sustained-release pellets, which is applied in the field of Weiyi sustained-release capsules and their preparation, can solve the problems of high price, unsuitability for long-term use, etc., and achieves stable drug effect, small dosage, and increased content of active ingredients. Effect

Inactive Publication Date: 2018-01-19
JIANGSU 707 NATURAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the drug has high bioavailability and good therapeutic effect, it is expensive and not suitable for long-term use

Method used

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  • Stomach tonifying sustained release capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The traditional Chinese medicine extract comprises the following components in parts by weight: 20 parts of bergamot, 10 parts of amomum, 20 parts of cork cork, 40 parts of toosendan, 40 parts of corydalis and 40 parts of hawthorn.

[0024] The ball core includes the following components by weight percentage of the total filling: 54.0% of traditional Chinese medicine extract, 17.0% of sucrose or microcrystalline cellulose, 2.1% of medicinal gelatin, and 2.5% of povidone or polyvinyl alcohol.

[0025] The controlled-release layer includes the following components by weight percentage of the total filling: 19.3% of Chinese medicine extract, 3.1% of cellulose acetate propionate or ethyl cellulose, 0.3% of polyethylene glycol 400, and 1.7% of anti-blocking agent.

[0026] A preparation method of Weiyi sustained-release capsules, comprising the following steps:

[0027] Step 1, taking each component by weighing;

[0028] Step 2, extract the volatile oil from the amomum by d...

Embodiment 2

[0033] The traditional Chinese medicine extract comprises the following components in parts by weight: 23 parts of bergamot, 15 parts of amomum, 27 parts of Phellodendron cortex, 50 parts of toosendan, 50 parts of corydalis, and 58 parts of hawthorn.

[0034] The ball core comprises the following components by weight percentage of the total filling: 54.3% of traditional Chinese medicine extract, 16.0% of sucrose or microcrystalline cellulose, 1.5% of medicinal gelatin, and 2.5% of povidone or polyvinyl alcohol.

[0035] The controlled-release layer includes the following components by weight percentage of the total filling: 20.2% of traditional Chinese medicine extract, 3.0% of cellulose acetate propionate or ethyl cellulose, 0.5% of polyethylene glycol 400, and 2.0% of anti-blocking agent.

[0036] A preparation method of Weiyi sustained-release capsules, comprising the following steps:

[0037] Step 1, taking each component by weighing;

[0038] Step 2, extract the volatile...

Embodiment 3

[0043] The traditional Chinese medicine extract comprises the following components in parts by weight: 35 parts of bergamot, 17 parts of amomum, 28 parts of Phellodendron cortex, 55 parts of toosendan, 45 parts of corydalis, and 50 parts of hawthorn.

[0044] The ball core includes the following components in percentage by weight of the total filling: 58.0% of traditional Chinese medicine extract, 16.0% of sucrose or microcrystalline cellulose, 2.5% of medicinal gelatin, and 3.0% of povidone or polyvinyl alcohol.

[0045] The controlled-release layer includes the following components by weight percentage of the total filling: 15.0% of traditional Chinese medicine extract, 3.4% of cellulose acetate propionate or ethyl cellulose, 0.2% of polyethylene glycol 400, and 1.9% of anti-blocking agent.

[0046] A preparation method of Weiyi sustained-release capsules, comprising the following steps:

[0047] Step 1, taking each component by weighing;

[0048] Step 2, extract the volati...

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Abstract

The invention discloses a stomach tonifying sustained release capsule and a preparation method thereof. The stomach tonifying sustained release capsule is characterized in that a stomach tonifying sustained release pill with which a capsule is filled consists of a pill core and a controlled release layer coating the pill core, wherein the pill core comprises the following components: a Chinese herbal medicine extract, saccharose or microcrystalline cellulose, medicinal gelatin and povidone or polyvinyl alcohol; the controlled release layer comprises the following components: a Chinese herbal medicine extract, cellulose-acetate propionate or ethyecellulose, polyethylene glycol 400 and an antiblocking agent; and the total weight of the pill core and the controlled release layer is 100%. Thepreparation method comprises the following steps: preparing the Chinese herbal medicine extract at first; then preparing the pill core and the controlled release layer; coating the pill core with thecontrolled release layer; and filling the capsule with the coated pill core. The stomach tonifying sustained release capsule is increased in content of active components, low in consumption, and stable in drug effect, and can be steadily released within 12 h in artificial gastric juice and artificial intestinal juice.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a Weiyi sustained-release capsule and a preparation method thereof. Background technique [0002] The spleen and stomach are the pivots for the ups and downs of the qi movement of the human body's internal organs, as well as the biochemical source of qi and blood for the human body and the sea of ​​water and valleys on which it depends for survival. With the improvement of living standards, people's work pressure increases and their lives are irregular, which will cause gastrointestinal discord, abdominal pain / loss of appetite and other symptoms for a long time. In recent years, the clinical incidence has been on the rise. [0003] Weiyi Capsule is a classic Chinese patent medicine, which mainly has the functions of soothing the liver and regulating qi, harmonizing the stomach, relieving pain, invigorating the stomach and eliminating food, etc. It...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9064A61K9/52A61P1/14A61P1/04A61P1/16
Inventor 窦宪刘芹
Owner JIANGSU 707 NATURAL PHARMA