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A kind of dissolvable dressing and preparation method thereof

A soluble and water-soluble technology, used in medical science, bandages, etc., can solve the problems of easy pollution, inability to achieve rapid mass production, complex production process, etc., to resist the invasion of foreign bacteria, excellent bacterial isolation effect, prevent secondary The effect of infection

Active Publication Date: 2020-05-08
SHANDONG ZHUSHITANG MEDICAL TREATMENT INSTR CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this type of dressing has a limited effect on the isolation of bacteria, and is prone to contamination, so dressings and drugs need to be changed frequently
For patients with deep and large wounds, frequent dressing changes and debridement will inevitably cause damage to the new epithelial tissue, which is not conducive to wound healing
At the same time, because the hydrogel dressing is in the state of aqueous solution before the polymerization reaction, the viscosity is extremely low, and it needs to be polymerized and formed in a special container. Dressing, less productive

Method used

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  • A kind of dissolvable dressing and preparation method thereof
  • A kind of dissolvable dressing and preparation method thereof
  • A kind of dissolvable dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] (1) At room temperature, polyethylene glycol methacrylate (molecular weight 1000 Da), cross-linking agent for soluble hydrogel, water, photoinitiator 2959 (2-hydroxy-4'-(2-hydroxyethoxy base)-2-methyl propiophenone), hydroxyethyl cellulose, antibacterial agent 1,1-hexamethylene bis[5-(4-chlorophenyl) biguanide] digluconate is 1 in mass ratio: (0.01~2): (1~100): (0.0001~0.1): (0.001~0.1): (0.001~0.1) Mix, stir and disperse evenly, and prepare a mixed solution;

[0052] (2) Apply the mixed solution evenly on the substrate to form a colloidal coating; make the colloidal coating undergo a crosslinking reaction under the action of ultraviolet light (ultraviolet light wave range: 180~380nm, ultraviolet light intensity is 20 mW / cm2, 200 seconds of irradiation time), a hydrogel layer is formed on the substrate;

[0053] (3) Peel off the hydrogel layer formed on the substrate to obtain a soluble hydrogel dressing with a thickness of 1.5 mm.

[0054] Among them, the molecular w...

Embodiment 2

[0064] (1) At room temperature, mix 2-acrylamide-2-methylpropanesulfonic acid, cross-linking agent for soluble hydrogel, water, initiator 2-hydroxy-4-(2-hydroxyethoxy)-2- Methylpropiophenone, sodium carboxymethylcellulose, and antibacterial agent benzyl dimethyl dodecyl ammonium chloride are in mass ratio 1: (0.01~2): (1~100): (0.0001~0.1): (0.001~0.1): (0.001~0.1) mix, stir and disperse evenly, and prepare a mixed solution;

[0065] (2) Apply the mixed solution evenly on the substrate to form a colloidal coating; make the colloidal coating undergo a crosslinking reaction under the action of ultraviolet light (ultraviolet light wave range: 180~480nm, ultraviolet light intensity is 100 mW / cm2, 20 seconds of irradiation time), a hydrogel layer is formed on the substrate;

[0066] (3) Peel off the hydrogel layer formed on the substrate to obtain a soluble hydrogel dressing with a thickness of 0.01-10 mm.

[0067] Among them, the molecular weight of the crosslinking agent for so...

Embodiment 3

[0071] (1) At room temperature, mix vinylpyrrolidone, cross-linking agent for soluble hydrogel, water, ammonium persulfate, polyacrylamide, and antibacterial o-hydroxybenzoic acid in a mass ratio of 1: (0.01~2): (1~ 100): (0.0001~0.1): (0.001~0.1): (0.001~0.1) mixed, stirred and dispersed evenly, and prepared into a mixed solution;

[0072] (2) Apply the mixed solution evenly on the substrate to form a colloidal coating; make the colloidal coating undergo a crosslinking reaction at 70°C for 12 hours to form a hydrogel layer on the substrate;

[0073] (3) Peel off the hydrogel layer formed on the substrate to obtain a soluble hydrogel dressing with a thickness of 0.01-10 mm.

[0074] Among them, the molecular weight of the crosslinking agent for soluble hydrogel is 4000 Da, and the molecular structure is:

[0075]

[0076] Part of the prepared soluble hydrogel dressing was soaked in an aqueous solution of ethyl cysteine ​​(10%), and the hydrogel was completely dissolved wit...

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Abstract

The invention discloses a medical antibacterial dissolvable soluble dressing and a preparation method thereof. A hydrogel dressing prepared according to the method disclosed by the invention is addedwith a thickening agent in a preparation process, so that the forming of the dressing is benefited under the condition that the use function of the dressing is not influenced. The hydrogel dressing prepared according to the method disclosed by the invention has an excellent bacteria-isolating effect and is capable of effectively resisting against the invasion of external bacteria, preventing the wound from secondary infection and accelerating the quick healing of the wound. The hydrogel dressing prepared by the method can be dissolved in a proper solvent and can be conveniently exchanged without mechanical tearing, the healing wound is prevented from being torn off and the pain of the patient can be relieved.

Description

technical field [0001] The invention belongs to the technical field of medical products, and in particular relates to a medical antibacterial and soluble hydrogel dressing and a preparation method thereof. Background technique [0002] Traditional wound dressings are made of natural plant fibers or animal hairs, such as gauze, cotton pads, wool, various types of oil gauze, etc. These dressings are only temporary covering materials and need to be replaced within a certain period of time. However, these wound dressings tend to stick to the wound when they are replaced, so when the dressing is torn off, the new epithelial cells or the wound that has gradually healed may be torn together, causing the user to suffer unbearably, and it is not necessary Conducive to wound healing. [0003] Hydrogel medical dressing is a new type of wound dressing developed in recent years. Compared with traditional gauze dressings currently used clinically, hydrogel dressings are breathable and mo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L26/00C08J3/075
Inventor 朱晓肸祝蕾朱坤福刘云晖彭新艳
Owner SHANDONG ZHUSHITANG MEDICAL TREATMENT INSTR CO LTD