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Implantable intestinal reactor

A reactor and intestinal lumen technology, applied in the field of implantable intestinal reactors, can solve the problems of weakened efficacy

Active Publication Date: 2022-05-03
UNIV GRENOBLE ALPES +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the efficacy of these routes is greatly weakened by the fact that these products are altered by the aggressive environment in the small intestine, especially for proteins, and that the active ingredients do not persist for long in the duodenum and jejunum, so The duodenum and jejunum are the regions where the concentrations of carbohydrates and more generally of various nutrients are greatest

Method used

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  • Implantable intestinal reactor
  • Implantable intestinal reactor
  • Implantable intestinal reactor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0091] 200 mg of chitosan was dissolved in 20 mL of acetic acid diluted to 0.5% by volume in water. To the initial mixture was added a crosslinker, 0.0045% mass / volume (g / 100 mL) of genipin, and caffeic acid in a ratio of 0.0032% mass / volume (g / vol) in chitosan viscous solution after 2 hours of stirring. / 100mL). Genipin was pre-dissolved in 12% dimethyl sulfoxide (DMSO) and 88% water (H 2 O) solution. Caffeic acid was pre-dissolved in ethanol at 4%.

[0092] After 30 minutes of stirring, 3 g of this mixture were extracted, spread on a smooth non-adhesive support (diameter 28 cm), such as an antistatic polystyrene cup, and incubated at ambient temperature ( A temperature of 20-30° C. is suitable) and dried for 2 to 4 days. In another experiment, it was dried at 25°C for three days.

[0093] A flexible nanoporous membrane is thus obtained. Experiments carried out by the applicant have shown that this flexibility is linked to the fact that the drying takes place at ambient...

Embodiment 2

[0095] With a cut-off threshold of 5000g.mol -1 In a cylindrical tube of cellulose acetate closed at one end (approximately 1 cm diameter and approximately 20 cm length), bacteria genetically modified to produce insulin were introduced up to a height of 4 cm in the tube. The other end of the tube is closed.

[0096] Then, the tube containing the bacteria was flattened and this flattened tube (approximately 1-2 mm in thickness) was placed in the first tape (about 20cm long and about 1.5cm wide), then place the second Strips (approximately 20 cm long and approximately 1.5 cm wide) to form the device according to the invention in sandwich form, the edges of the two strips have been sewn together.

[0097] by means of A strap (approximately 15 cm long and approximately 1 cm wide) secures the assembly to the stomach clamp. The clamp is positioned endoscopically on the wall of the gastric antrum. Through the working channel of the endoscope and using the clamp, the band is u...

Embodiment 3

[0099] use weaving Tape to form a 50cm x 1cm strip. At one of its ends, this band is sutured to the stomach clamp. The device was incubated for 48 hours in a culture medium of bacteria of the Lactobacillus acidophilus type. The clamp is positioned endoscopically on the wall of the gastric antrum. Through the working channel of the endoscope and using the clamp, the band is unwound and passed through the pylorus.

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Abstract

The invention relates to a device implantable in the intestinal lumen comprising a reactor comprising a porous or semipermeable membrane or coating and connected to elements for fixation to the intestinal or gastric wall. The reactor may be in the form of a belt, a structure having more than two faces or an open structure delimiting an internal cavity, comprising or formed by a semi-permeable or porous membrane. The reactor may also at least partially define a closed interior space with a semi-permeable or porous membrane. The reactor may contain or carry enzymes or microorganisms, especially bacteria or yeasts. It can be used to produce a chemical reaction with one or more molecules present in the intestine or to produce one or more biologically active molecules. It can be used in particular to consume sugars, disaccharides and simple sugars or to produce essential amino acids or other molecules that have a positive effect on health.

Description

technical field [0001] The present invention relates to devices enabling conversion or synthesis reactions in the intestine and their use for treating pathological conditions, correcting abnormalities or preventing the occurrence of pathological conditions or abnormalities. Background technique [0002] Glucose is a typical example of a molecule whose intestinal absorption may be desired to be reduced eg in the case of overweight or type II or even type I diabetes. [0003] Numerous proposals have been made to allow enzymes or microorganisms to reach the intestine without being destroyed by the gastric passage. can be mentioned for example This is a food supplement based on the enzymes galactosidase, especially alpha-galactosidase and beta-galactosidase, intended to treat lactose intolerance associated with a deficiency of this enzyme. Mention may be made more generally of various food supplements comprising bacteria such as bidifus bacteria. However, the efficacy of the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/00A61K35/747A61M25/04A61M31/00B01D69/14
CPCA61B5/6871B01D69/144A61K35/747A61B5/6873A61M25/04A61M31/002A61K38/28A61P3/04Y02A50/30A61L31/042A61L31/14A61L31/146A61L31/16A61L2300/43A61L2400/18A61M2210/1053A61M2210/1057A61M2210/106
Inventor P·桑坎D·施奈德M·莫兰D·马丁S·埃伊希A·泽布达J-P·阿尔卡拉斯F·雷什P·蒂维尼翁J·特吕A·勒古埃勒克B·图桑
Owner UNIV GRENOBLE ALPES