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An anticoagulant and antibacterial indwelling needle sleeve and preparation method thereof

An indwelling needle and anti-coagulation technology, which is applied in the field of medical devices, can solve the problems of less exploration of antibacterial function of the coating, great influence on the environment, and weak bonding strength, etc., and achieve long-lasting anti-coagulation and antibacterial effects and a wide range of sterilization , High adhesion effect

Active Publication Date: 2020-09-25
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the above patents have effectively improved the internal stability of the coating by constructing a cross-linked network, due to the lack of reactive functional groups in the heparin and quaternary ammonium salt components, the essence of the releasability of this type of coating has not changed
Secondly, the above-mentioned interaction mode between the coating and the base material is still a physical effect, the bonding strength between the two is weak, and it is greatly affected by the environment, and there is a risk of the coating falling off as a whole
In addition, the existing research mainly focuses on the declaration of anticoagulant function of the coating, and the antibacterial function of the coating is less explored

Method used

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  • An anticoagulant and antibacterial indwelling needle sleeve and preparation method thereof
  • An anticoagulant and antibacterial indwelling needle sleeve and preparation method thereof
  • An anticoagulant and antibacterial indwelling needle sleeve and preparation method thereof

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preparation example Construction

[0082] The present invention provides a method for preparing an anticoagulant and antibacterial indwelling needle sleeve described in the above technical solution, comprising the following steps:

[0083] A) reacting the hydrogen-absorbing quaternary ammonium salt solution with the structure of formula I and the heparin sodium solution to obtain the hydrogen-absorbing quaternary ammonium salt heparin complex;

[0084]

[0085] In formula I, R is selected from

[0086] R 1 and R 2 Alkyl independently selected from H or C1~C4; R 3 Alkyl group selected from C8~C16;

[0087] x - from Cl - 、Br - or I - ;

[0088] B) dissolving the hydrogen-absorbing quaternary ammonium salt heparin complex obtained in the step A) in an organic solvent, and then loading the obtained complex solution on the indwelling needle sleeve;

[0089] C) UV-curing the indwelling needle sleeve attached with the compound obtained in the step B) to obtain an anticoagulant and antibacterial indwellin...

Embodiment 1

[0104] Preparation of anticoagulant and antibacterial indwelling needle sleeve

[0105] A) Dissolve N-(4-benzoylbenzyl)-N,N-dimethyldodecyl-1-ammonium bromide in ultrapure water and prepare a hydrogen pumping solution with a concentration of 0.1g / ml Type quaternary ammonium salt solution; dissolve heparin sodium (molecular weight 7500-20000g / mol) in ultrapure water to prepare a heparin sodium solution with a concentration of 0.1g / ml; add the above-mentioned hydrogen pumping type quaternary ammonium salt solution drop by drop into 5ml of heparin sodium solution until a large amount of white precipitate precipitates out of the solution, and after standing for 30 minutes, filter under reduced pressure to obtain a white precipitate. The precipitate was washed three times with ultrapure water, and freeze-dried to obtain the hydrogen-absorbing quaternary ammonium salt heparin complex.

[0106] B) Dissolve the hydrogen-absorbing quaternary ammonium heparin complex obtained in the st...

Embodiment 2

[0109] A) Dissolve 4-(4-(diethylamino)benzoyl)-N,N-diethyl-N-octylphenylammonium iodide in ultrapure water to prepare a concentration of 0.125g / ml of hydrogen pumping type quaternary ammonium salt solution; dissolve heparin sodium (molecular weight 7500~20000g / mol) in ultrapure water to prepare a heparin sodium solution with a concentration of 0.125g / ml; the above hydrogen pumping type quaternary ammonium salt solution Add dropwise to 5ml of heparin sodium solution until a large amount of white precipitate precipitates out of the solution. After standing still for 30 min, the white precipitate was obtained by filtration under reduced pressure. The precipitate was washed three times with ultrapure water, and freeze-dried to obtain the hydrogen-absorbing quaternary ammonium salt heparin complex.

[0110] B) Dissolve the hydrogen-absorbing quaternary ammonium heparin complex obtained in the step A) in chloroform, and the prepared concentration is a 2% hydrogen-absorbing quatern...

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Abstract

The invention provides an anticoagulant antibacterial indwelling needle sleeve and a preparation method thereof. The anticoagulant antibacterial indwelling needle sleeve includes an indwelling needle sleeve and an anticoagulant grafted onto the indwelling needle sleeve through photoinitiation. Antibacterial coating; the coating includes sodium heparin and hydrogen-absorbing quaternary ammonium salt with the structure of formula I. The hydrogen pumping type quaternary ammonium salt undergoes hydrogen pumping and recombination reactions with the surface of the indwelling needle cannula base and heparin molecules, which makes the coating have high adhesion and good adhesion stability, and has strong universality and practicability; Release-type anticoagulant and antibacterial effect, no dissociation and shedding of coating components during cannula insertion, infusion, blood flushing, etc., long-lasting anticoagulant and antibacterial effects, and avoiding dissociation and leaching of quaternary ammonium There is a risk of systemic toxicity when salt enters the vein. Formula I; R is selected from or R 1 and R 2 independently selected from H or C1~C4 alkyl; R 3 Selected from C8~C16 alkyl; X ‑ from Cl ‑ 、Br ‑ or I ‑ .

Description

technical field [0001] The invention relates to the field of medical devices, in particular to an anticoagulant and antibacterial indwelling needle sleeve and a preparation method thereof. Background technique [0002] Indwelling catheter, also known as trocar, is composed of steel needle, cannula, needle seat and other main components. It is an infusion tool that inserts the needle core and the cannula into the blood vessel together when puncturing, and the sleeve stays in the blood vessel when the needle core is withdrawn. The venous indwelling needle abandons the shortcomings of traditional daily venipuncture and can be left in the vein for a long time, which not only reduces the blood vessel damage and mental pain caused by repeated punctures, but also reduces the workload of nurses in venipuncture and saves nurses' time. operating time. Especially when rescuing critically ill patients, it can be administered at regular intervals and multiple times, and the infusion ti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M5/158A61L31/10A61L31/08A61L33/00A61L33/04A61L33/10
Inventor 闫顺杰栾世方殷敬华石恒冲杨华伟张德海李娜黄尉戚祺林
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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