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Flax lignan microencapsulation method

A flax lignan and emulsifier technology, applied in microcapsules, capsule delivery, pharmaceutical formulations, etc., can solve the problems of oxidative degradation, quality degradation, nutritional loss, etc., to improve water solubility, improve compactness, and prolong storage period. Effect

Active Publication Date: 2018-02-02
右江民族医学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, flax lignan dry powder is not protected by other media, and it is prone to oxidative degradation under the action of light, high temperature and oxygen, resulting in nutrient loss and quality degradation.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A microencapsulation method of flax lignans, comprising the following steps:

[0024] (1) Preparation of core material: Dissolve flax lignans in ethanol with a weight ratio of 6 times, then add glycerol monostearate and lecithin emulsifier at a weight ratio of 1:3, flax lignans and emulsifier The weight ratio is 4:1, stir evenly, get core material solution;

[0025] (2) Prepare the wall material: Cyclodextrin, carboxymethyl chitosan octadecyl quaternary ammonium salt and xanthan gum with a weight ratio of 1:0.4:3 are used as the wall material, and 8 times the weight of the wall material is added water, heated up to 55°C, and stirred evenly to obtain wall material suspension;

[0026] (3) Ultrasonic homogenization: Add the above-mentioned core material solution and wall material suspension into an ultrasonic homogenizer at a weight ratio of 1:4, and homogenize for 30 minutes at an ultrasonic power of 200W and a temperature of 50°C to obtain a milky product;

[0027] (4...

Embodiment 2

[0030] A microencapsulation method of flax lignans, comprising the following steps:

[0031] (1) Preparation of core material: Dissolve flax lignans in ethanol with a weight ratio of 8 times, then add glycerol monostearate and lecithin emulsifier at a weight ratio of 1:2, flax lignans and emulsifier The weight ratio is 5:1, stir evenly, get core material solution;

[0032] (2) Prepare the wall material: Cyclodextrin, carboxymethyl chitosan octadecyl quaternary ammonium salt and xanthan gum with a weight ratio of 1:0.2:4 are used as the wall material, and 7 times the weight of the wall material is added water, heated up to 60°C, and stirred evenly to obtain wall material suspension;

[0033] (3) Ultrasonic homogenization: Add the above-mentioned core material solution and wall material suspension into an ultrasonic homogenizer at a weight ratio of 1:5, and homogenize for 25 minutes at an ultrasonic power of 150W and a temperature of 55°C to obtain a milky product;

[0034] (4...

Embodiment 3

[0037] A microencapsulation method of flax lignans, comprising the following steps:

[0038] (1) Preparation of core material: Dissolve flax lignans in ethanol with a weight ratio of 7 times, then add glycerol monostearate and lecithin emulsifier at a weight ratio of 1:4, flax lignans and emulsifiers The weight ratio is 6:1, stir evenly, get core material solution;

[0039] (2) Prepare the wall material: Cyclodextrin, carboxymethyl chitosan octadecyl quaternary ammonium salt and xanthan gum with a weight ratio of 1:0.5:5 are used as the wall material, and 8 times the weight of the wall material is added water, heated up to 50°C, and stirred evenly to obtain wall material suspension;

[0040] (3) Ultrasonic homogenization: Add the above-mentioned core material solution and wall material suspension into an ultrasonic homogenizer at a weight ratio of 1:6, and homogenize for 20 minutes at an ultrasonic power of 250W and a temperature of 60°C to obtain a milky product;

[0041] (...

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Abstract

The invention discloses a flax lignan microencapsulation method. The method comprises the following steps: dissolving flax lignans in ethanol with the weight 6-8 times the weight of the flax lignans,adding glyceryl monostearate and lecithin emulsifiers, and performing uniform stirring to obtain a core material solution; adding water with the weight 6-8 times the weight of a wall material to the wall material comprising cyclodextrin, carboxymethyl chitosan octadecyl quaternary ammonium salt and xanthan gum, heating the obtained solution to 50-60 DEG C, and performing uniform stirring to obtaina wall material suspension; adding the core material solution and the wall material suspension into an ultrasonic homogenizer according to a weight ratio of 1:(4-6), and performing homogenizing treatment for 20-30 min to obtain an emulsion; and conveying the emulsion into a granulation spray machine, performing spray drying, cooling the dried emulsion to room temperature, and packaging the driedemulsion to obtain flax lignan microcapsules. The flax lignan microcapsules prepared through the method can obviously improve the stability of the flax lignans and obviously prolong the storage period, and also can well preserve the active components of the flax lignans, and the method has the advantages of simple preparation process, simplicity in operation, low energy consumption, low cost, andeasiness in realization of industrial production.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine processing, in particular to a microencapsulation method of flax lignans. Background technique [0002] Flax lignans are physiologically active substances present in flax seed coats. The structure is very similar to human estrogen, and it is considered to be a kind of phytoestrogens. It is a natural ingredient formed by bimolecular polymerization of cinnamyl alcohol obtained from phenylalanine. Lignans have attracted great interest as a phytoestrogen, mainly because it has been shown to have anti-tumor effects, estrogenic and anti-estrogenic effects, inhibition of aromatase activity, inhibition of DNA and RNA synthesis, anti-virus, fungal And other characteristics, especially the unique effect of high-purity flax lignans on breast cancer and prostate cancer, so that it has been highly valued in the application of food therapy and pharmaceutical industry in recent years. [...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K47/40A61K47/36A61K31/7034A61P35/00
CPCA61K9/5036A61K31/7034
Inventor 黄锁义黄与路
Owner 右江民族医学院
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