Aerosol for treatment of chronic obstructive pulmonary disease

Abstract

The invention provides an aerosol for treatment of chronic obstructive pulmonary disease. The aerosol comprises an active ingredient, an additive and a propellant, wherein the active ingredient comprises three compounds of 1% to 99% by mass of ligustilide, 1% to 99% by mass of matrine and1% to 99% by mass of Peimine in proportion. The aerosol comprises 1 to 99% by mass of the active ingredient. The aerosol comprises two forms of a solution type and a mixed type. A COPD animal model is used to prove that the aerosol drug has the effects of inhibiting the secretion of related inflammatory factors, inhibiting the expression of mucus hypersecretion-related proteins, inhibiting apoptosis and necrosis of epithelial cells, and the like, can directly reach an affected area, takes the effects quickly, and has good treatment effect. Animal experiments prove that the aerosol has good anti-COPD effect and can be used in the preparation of a medicament for treating the chronic obstructive pulmonarydisease.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to an aerosol for treating chronic obstructive pulmonary disease (COPD). aerosol. Background technique [0002] Chronic Obstructive Pulmonary Disease (COPD) is a disease characterized by airflow limitation that is not fully reversible and is the result of a combination of small airway disease (bronchiolitis obliterans) and destruction of the lung parenchyma (emphysema) . COPD is one of the major diseases that seriously endanger public health in the world. According to the forecast of WHO, COPD will become the third leading cause of death in the world after cardiovascular and cerebrovascular diseases and tumors by 2030. In 2007, a survey of 20,245 adults in 7 regions in my country showed that the prevalence of COPD was as high as 8.2% among people over 40 years old. COPD not only has a high prevalence rate, but also develops progressively in the course of the disease, which can caus...

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Problems solved by technology

3. Antibiotics: According to the research support of the past 10 years, infection is a major factor in COPD. The use of antibiotics can control inflammation, but repeated use can easily lead to drug resistance

Generally speaking, these drugs have limited therapeutic effects and many side effects, which have little effect on preventing its progression and disease exacerbation

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