A kind of luteolin-glycyrrhizic acid conjugated bovine serum albumin drug-loaded nanoparticles and its preparation method and application

Abstract

The invention relates to luteolin-glycyrrhizic acid conjugated bovine serum albumin drug-loaded nanoparticles and a preparation and an application thereof. The luteolin-glycyrrhizic acid conjugated bovine serum albumin drug-loaded nanoparticles are a glycyrrhizic acid conjugated bovine serum albumin drug-loaded nanoparticles system through chemical modification of bovine serum albumin by glycyrrhizic acid, and then luteolin is coated in the glycyrrhizic acid conjugated bovine serum albumin drug-loaded nanoparticles system; wherein the glycyrrhizic acid conjugated bovine serum albumin drug-loaded nanoparticles having liver-targeting are taken as a carrier, and luteolin is taken as an anti-liver cancer bulk drug. The nanoparticles can improve the solubility, stability and targeting performance of luteolin and the drug-loaded nanoparticles to improve their bioavailability and anti-liver cancer efficacy. The encapsulation rate of the nanoparticles is increased to 30.33%. On an in-vitro cellular level, compared with GL-BSA-Lut-NPs by Lut, the drug-loaded nanoparticles have significantly increased water solubility, absorption, anti-tumor efficacy and the like.

Description

technical field [0001] The invention relates to polymer functionalized nanomaterials in the field of nanobiotechnology, in particular to a luteolin-glycyrrhizic acid conjugated bovine serum albumin drug-loaded nanoparticle and its preparation method and application. Background technique [0002] Luteolin (Luteolin, Lut) is a natural flavonoid compound, which exists in a variety of vegetables, fruits and Chinese herbal medicines. Spasm expectorant, treatment of diseases such as cardiovascular and nervous system. At present, studies at home and abroad have found that luteolin has obvious inhibitory effects on a variety of solid tumors and ascites cancer, and has a wide application prospect as an antitumor drug. However, there are still many problems in the treatment of luteolin as an anti-tumor drug, such as poor solubility, poor absorption, non-targeting, etc., which limit its long-term application. Therefore, it is necessary to research and develop a new dosage form to solv...

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Problems solved by technology

[0007] However, luteolin is a natural Chinese medicinal material monomer with various pharmacological activities. In recent years, it has been widely concerned because of its small side effects and high safety in anti-tumor applications. However, due to its low water solubility and poor absorbability. Well, poor targeting limits its application

The preparation of glycyrrhizic acid-coupled bovine serum albumin drug-loaded nanoparticles from luteolin Chinese medicinal material monomer has always had problems such as too large particle size, low drug-loading capacity, and poor efficacy at the in vitro cell level during the long-term exploration of the technical solution. Significant disadvantages

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