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Method for preparing PLGA/PCL/nHA composite bone repair porous scaffold by 3D printing technology as well as product and application of method

A 3D printing and porous scaffold technology, which is applied in medical science, tissue regeneration, prosthesis, etc., can solve problems such as poor compatibility and affecting the mechanical properties of mixed materials, and achieve the effect of improving mechanical properties

Inactive Publication Date: 2018-03-06
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the large difference between the melting points of PCL and PLGA, PCL will be thermally degraded in advance when melt mixing or processing is used; and PCL is a semi-crystalline polyester, which is easy to form crystals and has poor compatibility with PLGA in solvents. Affect the mechanical properties of hybrid materials

Method used

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  • Method for preparing PLGA/PCL/nHA composite bone repair porous scaffold by 3D printing technology as well as product and application of method
  • Method for preparing PLGA/PCL/nHA composite bone repair porous scaffold by 3D printing technology as well as product and application of method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Weigh 4 g of PLGA (10W) and PCL (8W) according to the mass ratio of 9:1, add 1 g of nHA powder into 10 mL of 1,4-dioxane, add 0.2 g of tributyl citrate as a compatibilizer, and Stir mechanically for more than 24 hours to fully dissolve and mix the materials evenly to prepare 3D printing "ink". figure 1 is the SEM image of the prepared hybrid material, nHA particles are uniformly dispersed in the polymer material. The 3D printer is Bio-Architect ®-WS. Put the above "ink" in the barrel of the 3D printer. The discharge needle is selected to be 150 μm. The printing parameters are set: each layer is printed in parallel, the gap is 0.2mm, and the Z-axis direction rises each time. The height is 0.2mm, the layers are vertically cross-stacked, the extrusion speed is set to 2mm / s, the temperature of the receiving platform is -15°C, and the printing size is 4mm*4mm*4mm cube. After the scaffold was printed, it was freeze-dried for 48 hours, and then dried in a vacuum oven at 50°C ...

Embodiment 2

[0028] Weigh 4 g of PLGA (10W) and PCL (8W) according to the mass ratio of 9:1, add 1 g of nHA powder into 10 mL of 1,4-dioxane, add 0.04 g of compatibilizer tributyl citrate, and mechanically Stir for more than 24 hours to fully dissolve and mix the materials evenly, and prepare the 3D printing "ink". The 3D printer is Bio-Architect ®-WS. Put the above "ink" in the barrel of the 3D printer. The discharge needle is selected to be 150 μm. The printing parameters are set: each layer is printed in parallel, the gap is 0.2mm, and the Z-axis direction rises each time. The height is 0.2mm, the layers are vertically cross-stacked, the extrusion speed is set to 2mm / s, the temperature of the receiving platform is -15°C, and the printing size is 4mm*4mm*4mm cube. After the scaffold was printed, it was freeze-dried for 48 hours, and then dried in a vacuum oven at 50°C for more than 24 hours. The compressive strength within the elastic deformation range of the material is 42.3MPa.

Embodiment 3

[0030] Weigh 4g of PLGA (10W) and PCL (8W) according to the mass ratio of 5:5, add 1g of nHA powder into 10mL of 1,4-dioxane, add 0.2g of compatibilizer tributyl citrate, and mechanically Stir for more than 24 hours to fully dissolve and mix the materials evenly, and prepare the 3D printing "ink". The 3D printer is Bio-Architect®-WS. Put the above "ink" in the barrel of the 3D printer. The discharge needle is selected to be 150 μm. The printing parameters are set: each layer is printed in parallel, the gap is 0.2mm, and the Z-axis direction rises each time. The height is 0.2mm, the layers are vertically cross-stacked, the extrusion speed is set to 2mm / s, the temperature of the receiving platform is -15°C, and the printing size is 4mm*4mm*4mm cube. After the scaffold was printed, it was freeze-dried for 48 hours, and then dried in a vacuum oven at 50°C for more than 24 hours. The compressive strength of the material within the range of elastic deformation is 44.6MPa.

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Abstract

The invention relates to a method for preparing a PLGA / PCL / nHA composite bone repair porous scaffold by a 3D printing technology as well as a product and application of the method. The method comprises the following steps: mixing 1,4-dioxane which is used as a solvent with PLGA and PCL according to a mass ratio of 9:(1-5):5, adding nHA powder according to a mass fraction of 10-25%, and finally adding tributyl citrate as a compatibilizer to improve the uniformity of the material; using the solution as 3D printing 'ink', carrying out 3D printing with a 3D printer, selecting a 150-micron discharging needle, and setting printing parameters as follows: parallel printing is adopted for each layer with gaps of 0.1-0.3mm, the Z-axis direction is raised by 0.2mm each time, the layers are verticallycrossed and stacked, the extrusion speed is set to 1.5-2mm / s, and the temperature of a receiving platform is -20 to -10 DEG C; and after the scaffold is printed, carrying out freeze-drying for 48 hours, and then drying the scaffold in a vacuum oven at 50 DEG C for 24 hours or more to prepare a PLGA / PCL / nHA composite bone repair porous scaffold. The preparation method provided by the invention issimple and feasible; the prepared porous bone repair scaffold has proper pore size and porosity, good biocompatibility and mechanical strength, thereby providing a new idea for clinical treatment of large bone defects, and having a wide clinical application prospect.

Description

technical field [0001] The present invention relates to a method in the technical field of biomedical materials, in particular to a method for preparing a PLGA / PCL / nHA composite porous scaffold for bone repair by 3D printing technology and its product and application, using 1,4-dioxane as a solvent , tributyl citrate and other compatibilizers are used as additives to control the ratio of each component in the composite material while maintaining a stable solution. Finally, a porous bone repair scaffold with good material uniformity and good mechanical properties is prepared by 3D printing technology. Background technique [0002] The repair of large bone defects is a major problem in clinical orthopedics. With the development of tissue engineering, tissue engineered bone scaffold materials are expected to replace traditional autologous or allogeneic bone, avoiding secondary trauma to patients, and repairing bone defects. Provides a new idea [Dimitriou R, Injury, 2011]. 3D p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/18A61L27/50A61L27/56A61L27/58B33Y10/00B33Y70/00B33Y80/00
CPCA61L27/12A61L27/18A61L27/50A61L27/56A61L27/58A61L2430/02B33Y10/00B33Y70/00B33Y80/00C08L67/04
Inventor 何丹农杨迪诚祝闪闪金彩虹许国华
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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