Sheep-derived low-molecular-weight heparin and its preparation method and application

Abstract

The invention discloses low-molecular-weight heparin derived from sheep, including sheep dateparin sodium, sheep nadroparin calcium, sheep tinzaparin sodium, sheep betaparin sodium and sheep bemiparin sodium. The low molecular weight heparins of sheep origin above all have common provenance characteristics. In terms of chemical structure, the content of the main disaccharide ΔUA2S‑GlcNS6S (ΔIS) is between 66%‑74%. Sheep low-molecular-weight heparin and pig-derived low-molecular-weight heparin have similar physical and chemical properties and biological activities, which expands the source of low-molecular-weight heparin drugs. The preparation method of sheep low-molecular-weight heparin introduced by the invention is simple and easy, and the process is stable. The obtained product is refined and can fully meet the requirements of various pharmacopoeias for the current low-molecular-weight heparin. Sheep low-molecular-weight heparin also has halal properties that porcine-derived low-molecular-weight heparin does not have. It has a huge market in the majority of Muslim populations, countries and regions, and can be used in anticoagulant, antithrombotic, anti-inflammatory, anticancer and halal drugs.

Description

technical field

[0001] The invention relates to low-molecular-weight heparin derived from goats, including goat-daparin sodium, goat-nadroparin calcium, goat-tingzaparin sodium, goat-paparin sodium and goat-bemiheparin sodium, which are halal and belong to the field of medical and biotechnology. Background technique

[0002] Low Molecular Weight Heparin (LWMH) is currently the most widely used and most important anticoagulant and antithrombotic drug in clinical practice. Some low molecular weight heparins are also widely used in anti-inflammatory and anti-cancer clinical treatments. Low-molecular-weight heparin is prepared by depolymerization of natural macromolecular-weight heparin. At present, the source of medical low-molecular-weight heparin is almost all porcine intestinal mucosal heparin.

[0003] There are certain differences in the chemical structure of heparin derived from different animals or organs. The molecular structure of heparin consists of glucosamine and o...

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