Unlock instant, AI-driven research and patent intelligence for your innovation.

Preparation method of two-phase mixed dual-function high-molecular slow-release membrane

A dual-function, high-molecular technology, applied in the field of simple preparation of drug-loaded composite membranes, can solve the problems of curcumin toxicity, etc., and achieve the effect of reducing interfacial energy and good biocompatibility

Active Publication Date: 2018-03-16
FUZHOU UNIV
View PDF9 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no research report showing that curcumin is toxic to animals or humans, and the safe dose in clinical trials is even as high as 8000mg / day

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of two-phase mixed dual-function high-molecular slow-release membrane
  • Preparation method of two-phase mixed dual-function high-molecular slow-release membrane
  • Preparation method of two-phase mixed dual-function high-molecular slow-release membrane

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) Dissolve 0.5 g chitosan in 1.0% acetic acid solution;

[0028] (2) Under magnetic stirring, add 200 mg of aloe vera powder and stir well to make it evenly mixed;

[0029] (3) Put 200 mg of PLGA and 0.5 mg of Cur in a mixed solution containing 3 mL of dichloromethane and acetone (dichloromethane: acetone = 1: 3, v / v), and ultrasonicate the homogenizer for 1 min mixed into a homogeneous solution;

[0030] (4) Slowly add the solution obtained in step (3) into the solution obtained in step (2) under ultrasonic conditions, and the homogenizer is ultrasonicated for 5 minutes;

[0031] (5) The solution obtained in step (4) was magnetically stirred for 4 h to remove the organic solvent, poured into different molds and dried at room temperature to obtain the polymer sustained-release film, in which the final concentration of aloe was 2 wt%.

Embodiment 2

[0033] (1) 1.5 g chitosan was dissolved in 2.5% acetic acid solution;

[0034] (2) Under magnetic stirring, add 400 mg aloe vera powder, stir well to make it evenly mixed;

[0035] (3) Put 750 mg of PLGA and 2.5 mg of Cur in a mixed solution containing 5 mL of dichloromethane and acetone (dichloromethane: acetone = 1: 3, v / v), and ultrasonicate the homogenizer for 1 min mixed into a homogeneous solution;

[0036] (4) Slowly add the solution obtained in step (3) into the solution obtained in step (2) under ultrasonic conditions, and the homogenizer is ultrasonicated for 10 minutes;

[0037] (5) The solution obtained in step (4) was magnetically stirred for 4 h to remove the organic solvent, and then poured into different molds for vacuum freeze-drying to obtain the polymer sustained-release film, in which the final concentration of aloe was 4 wt%.

Embodiment 3

[0039] (1) Dissolve 0.8 g chitosan in 2.0% acetic acid solution;

[0040] (2) Under magnetic stirring, add 300 mg aloe vera powder, stir well to make it evenly mixed;

[0041] (3) Put 500 mg of PLGA and 1.5 mg of Cur in a mixed solution containing 4 mL of dichloromethane and acetone (dichloromethane: acetone = 1:3, v / v), and ultrasonicate the homogenizer for 1 min mixed into a homogeneous solution;

[0042] (4) Slowly add the solution obtained in step (3) to the solution obtained in step (2) under ultrasonic conditions, and the homogenizer is ultrasonicated for 8 minutes;

[0043] (5) The solution obtained in step (4) was magnetically stirred for 4 h to remove the organic solvent, and then poured into different molds for vacuum freeze-drying to obtain the polymer sustained-release film, in which the final concentration of aloe was 3 wt%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preparation method of a two-phase mixed dual-function high-molecular slow-release membrane. Selected materials have the advantages of good biological compatibility and internal degradability and are used with novel drug delivery systems such as micro-spheres, nanoparticles and vesicles to realize local drug delivery. Inflammation complication is resisted, skin regeneration and anti-blocking are promoted, composite materials are prepared by in-situ synthesis, the method for preparing oil / water two-phase uniform mixed composite materials is promising, interface energy of an oil / water phase interface can be effectively reduced, oil-phase PLGA (polylactic-co-glycolic acid) particles are uniformly dispersed on an organic substrate, chitosan / aloe and curcumin loaded poly-lactide-co-glycolide micro-spheres are combined, and the dual-function drug controlled slow-release membrane is prepared in a biomimetic manner.

Description

technical field [0001] The invention belongs to the field of pharmaceutical biodegradable polymer materials and preparation thereof, and in particular relates to a simple preparation method of a drug-loaded composite film for drug sustained release. Background technique [0002] In the process of drug release, traditional drug dosage forms are difficult to control and delay the release of drugs, and there will be problems such as poor stability, insufficient drug efficacy, and difficult to control drug toxicity. Local drug delivery systems mainly include implants and polymer films. Implants can be used as a local drug to increase the regulation of drug concentration in specific parts, make the drug closer to the target tissue, reduce the blood concentration fluctuation of the drug, and thereby reduce the Drug side effects. Therefore, implants have irreplaceable advantages in the treatment of cervicitis. Films composed of degradable aliphatic polyesters and natural macromol...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/12A61K47/36A61K47/46A61K47/34A61P31/00A61P29/00A61P39/06A61P1/16A61P9/00A61P7/02A61P19/02A61P35/00A61P37/04A61P43/00A61K9/50
CPCA61K9/5031A61K9/7007A61K31/12A61K47/34A61K47/36A61K47/46
Inventor 陈景帝刘小翠赵耀邹琳张其清
Owner FUZHOU UNIV