Aminophylline tablet and preparation method thereof

A technology of aminophylline and cholophylline, which is applied in the field of aminophylline tablets and its preparation, can solve problems such as narrow range of blood drug concentration, improper control of drug dosage, cramps and allergies, etc., and achieve mass production and enrich health care effects , Improve the effect of bad taste

Inactive Publication Date: 2018-03-20
HUAYI PHARMA ANHUI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Ordinary aminophylline preparations need to be taken orally three times a day, night medication affects sleep, and aminophylline treatment blood concentration range is narrow, the blood concentration range is 10-20ug / mL, its bioavailability is related to the elimination rate in the body, Individual differences are large, and they are easily affected by various factors such as physiology, pathology, and drug combination. If the dosage is improperly controlled, the curative effect may not be obvious or poisoning may occur. After frequent administration, the blood concentration is prone to "peak and valley phenomenon". Cause side effects such as headache, nausea, vomiting, dizziness, insomnia, upper abdominal pain, fever, rapid heartbeat, cramps, and allergies

Method used

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  • Aminophylline tablet and preparation method thereof
  • Aminophylline tablet and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0021] An aminophylline tablet, made of the following raw materials in weight ratio: 45 parts of aminophylline, 45 parts of cholophylline, 305 parts of povidone K, 5 parts of whole milk powder, 5 parts of silicon dioxide, and 5 parts of vitamin C , 5 parts of vitamin E, 3 parts of honey, 0.5 parts of mugwort leaves, 1 part of kudzu root, 2 parts of medicinal soybean oil, and 2 parts of carboxymethyl cellulose.

[0022] Among them, Artemisia argyi and Pueraria lobata root were first soaked in ethanol for 12 hours, rinsed with sterile water, dried and crushed to nanometer scale.

[0023] A preparation method of aminophylline tablet, comprising the steps of:

[0024] (1) Take the aminophylline and cholophylline of formula quantity, granulate with 80 mesh sieve, dry at 50-60 ℃;

[0025] (2) Weigh the formula amount of povidone K30, whole milk powder, silicon dioxide, vitamin c, vitamin e, honey, mugwort leaf, kudzu root, dispersant, slow release agent, add purified water, ultraso...

Embodiment 2

[0029] An aminophylline tablet, made of the following raw materials in weight ratio: 60 parts of aminophylline, 55 parts of cholophylline, 306 parts of povidone K, 6 parts of whole milk powder, 6 parts of silicon dioxide, and 6 parts of vitamin C , 6 parts of vitamin E, 4 parts of honey, 0.7 parts of mugwort leaves, 2 parts of kudzu root, 3 parts of medicinal soybean oil, and 3 parts of carboxymethyl cellulose.

[0030] Among them, Artemisia argyi and Pueraria lobata root were first soaked in ethanol for 12 hours, rinsed with sterile water, dried and crushed to nanometer scale.

[0031] A preparation method of aminophylline tablet, comprising the steps of:

[0032] (1) Take the aminophylline and cholophylline of formula quantity, granulate with 80 mesh sieve, dry at 50-60 ℃;

[0033] (2) Weigh the formula amount of povidone K30, whole milk powder, silicon dioxide, vitamin c, vitamin e, honey, mugwort leaf, kudzu root, dispersant, slow release agent, add purified water, ultras...

Embodiment 3

[0037] An aminophylline tablet, made of the following raw materials in weight ratio: 55 parts of aminophylline, 48 parts of cholophylline, 306 parts of povidone K, 6 parts of whole milk powder, 6 parts of silicon dioxide, and 6 parts of vitamin C , 6 parts of vitamin E, 4 parts of honey, 0.7 parts of mugwort leaves, 2 parts of kudzu root, 3 parts of medicinal soybean oil, and 3 parts of carboxymethyl cellulose.

[0038] Among them, Artemisia argyi and Pueraria lobata root were first soaked in ethanol for 12 hours, rinsed with sterile water, dried and crushed to nanometer scale.

[0039] A preparation method of aminophylline tablet, comprising the steps of:

[0040] (1) Take the aminophylline and cholophylline of formula quantity, granulate with 80 mesh sieve, dry at 50-60 ℃;

[0041] (2) Weigh the formula amount of povidone K30, whole milk powder, silicon dioxide, vitamin c, vitamin e, honey, mugwort leaf, kudzu root, dispersant, slow release agent, add purified water, ultras...

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Abstract

The invention provides an aminophylline tablet and a preparation method thereof, which relate to the technical field of medicine, including aminophylline, cholophylline, povidone K30, whole milk powder, silicon dioxide, vitamin C, vitamin E, honey, and mugwort leaves , kudzu root, dispersant, sustained-release agent; comprising the following steps: (1) taking aminophylline and chophyline of formula quantity, 80 mesh sieve granulation, 50-60 ℃ drying; (2) weighing formula quantity Povidone K30, whole milk powder, silicon dioxide, vitamin C, vitamin E, honey, mugwort leaf, kudzu root, dispersant, sustained-release agent, added purified water, ultrasonic treatment for 12‑15min, heated in a water bath at 75°C; (3 ) adding the material obtained in step (1) to the material obtained in step (2), mechanically stirring, and mixing uniformly; (4) compressing the material in step (3), drying to obtain aminophylline tablets. The method for making the aminophylline into tablets of the invention has simple operation, good reproducibility, and is easy to realize mass production.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an aminophylline tablet and a preparation method thereof. Background technique [0002] Asthma is a disease characterized by airway hyperresponsiveness and reversible airway narrowing, clinically characterized by episodic expiratory dyspnea, cough and wheezing. At present, about 300 million people worldwide suffer from asthma, and 1 in every 250 deaths is caused by asthma. In 2000, the incidence of asthma among Chinese residents was 1.2%, and the total number of people was 15.6 million, an increase of 75% compared with 1980. Nearly 62,000 people died of asthma every year in my country, and it has been on the rise in recent years. [0003] Aminophylline is an antiasthmatic drug, and its chemical name is 1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione-1,2-ethylenediamine salt dihydrate. Aminophylline can act directly on bronchial smooth muscle, relieve spasm, achieve the purpose of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/522A61K36/488A61K47/46A61P11/06A61P37/04A61K31/375A61K31/355
CPCA61K9/2068A61K31/355A61K31/375A61K31/522A61K36/282A61K36/488A61K2300/00
Inventor 操铖高煜
Owner HUAYI PHARMA ANHUI CO LTD
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