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Pioglitazone hydrochloride tablet

A technology of pioglitazone hydrochloride tablets and pioglitazone hydrochloride, which is applied in the field of pioglitazone hydrochloride tablets, can solve the problems of poor solubility and low bioavailability of pioglitazone hydrochloride, and achieve the effects of improving bioavailability, increasing residence time, and improving solubility

Inactive Publication Date: 2018-03-23
广州市桐晖药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In order to solve the technical problems of poor solubility and low bioavailability of pioglitazone hydrochloride in the prior art, the invention provides a pioglitazone hydrochloride tablet with high bioavailability and improved solubility

Method used

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  • Pioglitazone hydrochloride tablet
  • Pioglitazone hydrochloride tablet
  • Pioglitazone hydrochloride tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020]

[0021] Weigh the pioglitazone hydrochloride, lecithin and stearic acid of the prescription to prepare the compound, add xylitol, malic acid polymer and magnesium stearate to the compound, stir well, then add the soft material made of absolute ethanol, 24 Granulate with a mesh sieve, dry, and tablet.

Embodiment 2

[0023]

[0024] The preparation method is the same as in Example 1.

Embodiment 3

[0026]

[0027] The preparation method is the same as in Example 1.

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PUM

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Abstract

The invention discloses a pioglitazone hydrochloride tablet, and belongs to the technical field of preparations. The pioglitazone hydrochloride tablet comprises a pioglitazone hydrochloride composition and a water-soluble auxiliary, wherein the pioglitazone hydrochloride composition is a composition of pioglitazone hydrochloride and lecithin, the compounding weight ratio of the pioglitazone hydrochloride to the lecithin is 1 to (2-8), the water-soluble auxiliary comprises sugar alcohol, an organic acid polymer and a lubricant, and the weight ratio of the sugar alcohol to the organic acid polymer is 1 to (3-12). The pioglitazone hydrochloride tablet has high bioavailability and increased solubility.

Description

technical field [0001] The invention relates to the technical field of preparations, in particular to a pioglitazone hydrochloride tablet. Background technique [0002] Pioglitazone is a thiazolidinedione antidiabetic drug, which is an insulin sensitizer. Its mechanism of action is to highly selectively activate peroxisome growth factor-activated receptors, adjust insulin control genes to strengthen the action of insulin in surrounding muscles, adipose tissue and liver, and promote the consumption of glucose and 2-deoxyglucose, thereby Improve the metabolism of glucose and lipids, have obvious anti-glucagon effect, reduce the level of insulin in plasma, and also inhibit the generation of glucose in the liver, reduce glyceride in blood, inhibit the synthesis of cholesterol in vivo and increase the oxidation of fatty acid effect. Clinical studies have shown that pioglitazone can improve insulin sensitivity in patients with insulin resistance, improve insulin responsiveness t...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/4439A61K47/24A61K47/12A61K47/20A61K47/26A61K47/34A61P3/10A61P13/12
CPCA61K9/2013A61K9/2018A61K9/204A61K31/4439
Inventor 张彤丽
Owner 广州市桐晖药业有限公司
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