Rubidium-containing multistage mesoporous bioactive glass, and preparation method and application thereof

A bioactive glass and mesoporous technology, applied in tissue regeneration, medical science, prosthesis, etc., can solve the problems of shortening the preparation time, achieve the effects of shortening the time, high specific surface area, and ensuring stability

Active Publication Date: 2018-03-23
广州光鼎科技集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] One of the purposes of the present invention is to overcome the defects of the prior art and provide a rubidium-containing multilevel mesoporous bioactive glass and a preparation method thereof. The sol-gel method is used to add rubi

Method used

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  • Rubidium-containing multistage mesoporous bioactive glass, and preparation method and application thereof
  • Rubidium-containing multistage mesoporous bioactive glass, and preparation method and application thereof
  • Rubidium-containing multistage mesoporous bioactive glass, and preparation method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0039] The preparation method of rubidium-free MBG described in this embodiment comprises the following steps:

[0040] a Dissolve 8g of P123, 2.79g of calcium nitrate, 1.44g of triethyl phosphate, and 13.4g of ethyl orthosilicate in 120g of ethanol to obtain solution A, in which the molar ratio of calcium, phosphorus and silicon is 15:5:80.

[0041] b The solutions were mixed in a beaker at 20° C. and stirred by means of a magnetic stirrer for 12 hours.

[0042] c Immerse the polyurethane sponge in the gel for 10 minutes, then transfer the sponge to a petri dish, heat it with a hair dryer, and dry it for 5 minutes, and repeat this step 4 times.

[0043] d After being completely dried, calcined at 700° C. for 5 hours to obtain a rubidium-free mesoporous bioactive glass drug carrier.

Embodiment 2

[0045] The preparation method of rubidium-containing MBG described in this embodiment comprises the following steps:

[0046] a Dissolve 8 g of template agent P123, 1.86 g of calcium nitrate, 1.44 g of triethyl phosphate, and 13.4 g of ethyl orthosilicate in 120 g of ethanol to obtain solution A.

[0047] b Dissolve 0.48 g of target dopant rubidium chloride in 10 ml of deionized water to obtain solution B, in which the molar ratio of rubidium, calcium, phosphorus, and silicon is 5:10:5:80.

[0048] c Pour solution B into solution A and mix in a beaker at 20°C, and stir for 12 hours with the help of a magnetic stirrer to obtain a mixed gel.

[0049] d Immerse the polyurethane sponge in the obtained gel for 10 minutes, transfer the sponge to a petri dish, heat it with a hair dryer, and dry it for 5 minutes, and repeat this step 4 times.

[0050] e After being completely dried, it was calcined at 700° C. for 5 hours to obtain a rubidium-containing mesoporous bioactive glass drug c...

Embodiment 3

[0052] The preparation method of rubidium-containing MBG described in this embodiment comprises the following steps:

[0053] a Dissolve 8 g of template agent P123, 0.93 g of calcium nitrate, 1.44 g of triethyl phosphate, and 13.4 g of ethyl orthosilicate in 120 g of ethanol to obtain solution A.

[0054] b Dissolve 0.96 g of the target dopant rubidium chloride in 20 ml of deionized water to obtain solution B, in which the molar ratio of the four elements of rubidium, calcium, phosphorus, and silicon is 10:5:5:80.

[0055] c Pour solution B into solution A and mix in a beaker at 20°C, and stir for 12 hours with the help of a magnetic stirrer to obtain a mixed gel.

[0056] d Immerse the polyurethane sponge in the obtained gel for 10 minutes, transfer the sponge to a petri dish, heat it with a hair dryer, and dry it for 5 minutes, and repeat this step 4 times.

[0057] e After being completely dried, calcined at 700° C. for 5 hours to obtain a rubidium-containing mesoporous bi...

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Abstract

The invention belongs to the field of medical materials for repairing bone injury and related tissues, and particularly discloses rubidium-containing multistage mesoporous bioactive glass, and a preparation method and application thereof. The preparation method comprises the following steps: (1) dissolving a template agent, a calcium source, a phosphorus source and a silicone source in ethyl alcohol to obtain a solution A, and dissolving a rubidium source in deionized water to obtain a solution B; (2) mixing the solution A and the solution B, and stirring for 6 to 12 hours by means of a magnetic stirrer to obtain mixed gel; (3) soaking polyurethane sponge in the mixed gel in the step (3) for 10 to 20 minutes, taking the sponge out, heating and blow-drying the sponge, and repeating the steps for 3 to 6 times; and (4) after the sponge is completely dried, sintering to obtain a rubidium-containing mesoporous bioactive glass medicine carrier. The bioactive glass and the medicine carrier disclosed by the invention have the advantages of high specific surface area, high biocompatibility, high antibacterial property and the like, is applicable to a bone repair material, promotes wound healing of related tissues, and prevents bacterial infection.

Description

technical field [0001] The invention belongs to the field of multifunctional biomedical materials, and specifically relates to a rubidium-containing multilevel mesoporous bioactive glass and a preparation method thereof, which is used as a drug carrier for bone repair. Background technique [0002] Treating bone defects, especially large ones caused by trauma, infection, tumors or genetic malformations, presents a significant challenge to clinicians. To address these issues, bioactive mesoporous scaffolds have been extensively studied for bone tissue regeneration. In order to better regenerate defective bone tissue, bioactive scaffolds should not only be osteoconductive (for guiding new bone growth), but also be osteogenic (for promoting new bone formation) and angiogenic (for inducing ability to form blood vessels). Furthermore, osteomyelitis caused by bacterial infection is a frequent and serious complication in bone reconstruction surgery. Conventional treatment is adm...

Claims

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Application Information

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IPC IPC(8): A61L27/56A61L27/54A61L27/50A61L27/10A61L27/02
CPCA61L27/025A61L27/10A61L27/50A61L27/54A61L27/56A61L2300/216A61L2300/406A61L2300/602A61L2430/02
Inventor 刘咏和祥谭彦妮
Owner 广州光鼎科技集团有限公司
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