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Technology for extracting shikimic acid from fresh illicium verum

A technology of shikimic acid and star anise, applied in the field of extraction technology, can solve the problems of organic structure change, no energy consumption, long cooling time, etc., and achieve the effects of short production cycle, low energy consumption, and low safety hazards

Inactive Publication Date: 2018-04-13
浙江工业大学上虞研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional thermal reflux method takes a long time to extract, consumes a lot of energy, and the extraction rate is also low
The intensity of sound and vibration is low during ultrasonic extraction; under high temperature conditions during microwave extraction, some organic structures in the sample may be changed and destroyed, and a long cooling time is required before taking out the extract
[0005] In conclusion, there have been many reports on the extraction and purification of shikimic acid, but a method with low energy consumption, short time, clean process, simple process and good separation effect has not been found so far, so a new and efficient shikimic acid extraction and purification method has been developed. Purification technology is very necessary

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] 1) Preparation of shikimic acid extract: pulverize fresh star anise, add distilled water with a weight ratio of 1:1, and then add star anise with 0.3% pectinase and 0.3% hemicellulase in order by weight, Enzyme hydrolyze at 25°C for 2 hours, heat up to 100°C to inactivate the enzyme for 20 minutes, and then treat it under a microwave with an output power of 600W for 3 minutes to obtain an enzymolysis solution; Extracted 3 times, and combined the extracts;

[0021] 2) Preparation of magnetic molecularly imprinted polymer: Suspension polymerization method, using shikimic acid as template molecule, oleic acid modified nano-Fe 3 o 4 Particles are magnetic components, tetravinylpyridine is a functional monomer, carboxyethyl cellulose aqueous solution is a dispersant, and ethylene glycol dimethacrylate is a crosslinking agent to prepare an octagonal shikimic acid magnetic molecular imprinted polymer.

[0022] 3) Mix the magnetic molecularly imprinted polymer obtained in ste...

Embodiment 2

[0024] 1) Grind the fresh star anise, add distilled water with a weight ratio of 1:2, and then add 0.5% pectinase and 0.7% hemicellulase in parts by weight, and enzymatically After 2 hours of hydrolysis, the temperature was raised to 100°C to inactivate the enzyme for 20 minutes, and then treated under microwave conditions with an output power of 600W for 2 minutes to obtain an enzymolysis solution; the enzymolysis solution was extracted with ethanol at a temperature of 70-90°C for 2- 3 times, combined extracts;

[0025] 2) Magnetic Molecularly Imprinted Polymer: Suspension polymerization method, using shikimic acid as template molecule, acid-modified nano-Fe 2 o 3 Particles are magnetic components, tetravinylpyridine is a functional monomer, carboxyethyl cellulose aqueous solution is a dispersant, and ethylene glycol dimethacrylate is a crosslinking agent to prepare an octagonal shikimic acid magnetic molecular imprinted polymer.

[0026] 3) Mix the magnetic molecularly imp...

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Abstract

The invention discloses a technology for extracting shikimic acid from fresh illicium verum. According to the technology, the fresh illicium verum serving as a raw material can be directly used without drying, energy consumption is low, the yield of shikimic acid is high and the safety hidden trouble is low. Ethanol is employed for extraction after enzymolysis treatment, and then a prepared magnetic molecularly imprinted polymer is used to adsorb the shikimic acid in a crude extract, so that separation of the shikimic acid can be realized simply and efficiently.

Description

technical field [0001] The invention relates to an extraction process, in particular to a process for extracting shikimic acid from fresh star anise. Background technique [0002] Star anise, also known as star anise, star anise, aniseed, scientific name Illiciumverum, is an important economic tree species with "medicine and food from the same source" in southern China. Yunnan, southern Fujian, western Guangdong. Star anise fruit can be used as seasoning, leaves and fruit can be steamed aromatic oil, called star anise oil, its content is generally 5% to 12%, fennel oil can be used in the food industry such as making liqueur; Spices for perfumes and cosmetics; in the medical industry, it can be used to prepare bactericides, kidney-invigorating agents, and prolactins, etc. In addition, the shikimic acid extracted from its fruit is also the key component of the only synthetic drug oseltamivir phosphate (Tamiflu) recommended by the International Health Organization to synthesi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C51/42C07C51/47C07C62/32
CPCC07C51/42C07C51/47C07C62/32
Inventor 贾建洪
Owner 浙江工业大学上虞研究院有限公司
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