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Preparation method of compound indigowoad root granular electuary

A technology of compound banlan and granule granules, which is applied to medical preparations with no active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc. It can solve problems such as affecting application, large dosage for patients, and many impurities, and achieve practical Strong, simple preparation method, improved extraction process effect

Inactive Publication Date: 2018-04-24
ANHUI YONSENT PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The traditional extraction method is rough, complex, outdated, and has many impurities, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects the clinical application of this product, and the extracted Radix isatidis contains low active ingredients. The long heat treatment process, the active ingredient is easy to decompose under high temperature and acidic conditions, resulting in a decrease in the retention rate of the active ingredient, which seriously affects the quality and clinical efficacy of subsequent preparations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] S1, preparation of isatidis extract

[0032] Wash the isatidis root and soak for 2 hours, then decoct the soaked isatidis root together with the soaking liquid for 1 hour, collect the decoction liquid, add water to the dregs and continue to decoct twice, the second time for 1 hour, and the third time for 1 hour, Concentrate under reduced pressure after merging the three decoction liquids to obtain the isatidis extract with a relative density of 1.08;

[0033] S2, enzymatic hydrolysis

[0034] Put the extract of Radix Radix in a constant temperature water bath, the temperature of the water bath is 40°C, add the mixed enzymolysis solution of polysaccharase and protease for enzymolysis for 10 hours, to extract polysaccharides, free amino acids and adenosine in the extract of Radix Radix and other active ingredients to obtain Radix Radix culture fluid;

[0035] S3, microbial degradation

[0036] Add 10 g of 0.2% potassium dihydrogen phosphate and 20 g of 0.1% ammonium su...

Embodiment 2

[0042] S1, preparation of isatidis extract

[0043] Wash the Radix Radix and soak it for 3 hours, then decoct the soaked Radix Radix together with the soaking liquid for 2 hours, collect the decoction liquid, add water to the dregs and continue decocting twice, the second time for 2 hours, and the third time for 1 hour. Concentrate under reduced pressure after merging the three decoction liquids to obtain the isatidis extract with a relative density of 1.31;

[0044] S2, enzymatic hydrolysis

[0045] Put the extract of Radix Radix in a constant temperature water bath, the temperature of the water bath is 45°C, add the mixed enzymolysis solution of polysaccharase and proteolytic enzyme for enzymolysis for 15 hours, to extract polysaccharides, free amino acids and adenosine in the extract of Radix Radix and other active ingredients to obtain Radix Radix culture fluid;

[0046] S3, microbial degradation

[0047] Add 50 g of 0.2% potassium dihydrogen phosphate and 60 g of 0.1% ...

Embodiment 3

[0053] S1, preparation of isatidis extract

[0054] Wash the Radix Radix and soak it for 2.5 hours, then decoct the soaked Radix Radix together with the soaking liquid for 2 hours, collect the decoction liquid, add water to the dregs and continue decocting twice, decoct the second time for 1.5 hours, and decoct the third time 1h, after merging the three decoctions, concentrating under reduced pressure to obtain the isatidis extract with a relative density of 1.22;

[0055] S2, enzymatic hydrolysis

[0056] Put the extract of Radix Radix in a constant temperature water bath, the temperature of the water bath is 42°C, add the mixed enzymolysis solution of polysaccharase and protease for enzymolysis for 12 hours, to extract polysaccharides, free amino acids and adenosine in the extract of Radix Radix and other active ingredients to obtain Radix Radix culture fluid;

[0057] S3, microbial degradation

[0058] Add 40 g of 0.2% potassium dihydrogen phosphate and 30 g of 0.1% ammo...

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PUM

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Abstract

The invention discloses a preparation method of a compound indigowoad root granular electuary. The method specifically includes the following steps of preparation of indigowoad root leaching liquid, enzymolysis, micro-biological degradation, freeze drying and prilling. The preparation method improves a traditional extraction process, and in the enzymolysis procedure, polysaccharide, free amino acid, adenosine and other effective components in the indigowoad root leaching liquid are extracted; micro-biological fermentative degradation is conducted to obtain alkaloid and other effective components, then a freeze drying technique is adopted for drying and water removal, and the effective components of indigowoad roots cannot be damaged at the same time, so that the problem that by adopting awater extraction and alcohol precipitation method, the dosage of ethyl alcohol influences the whole preparation process and the preparation stability is solved; the preparation method is simple, hightemperature reactions are not required, the effective components in the indigowoad roots are extracted to the maximum degree, the practicability is high, and the preparation method is suitable for industrialized production.

Description

technical field [0001] The invention belongs to the field of biopharmaceuticals, and in particular relates to a preparation method of compound isatis root granules. Background technique [0002] Banlangen Granules have the effects of clearing heat and detoxifying, cooling blood and relieving sore throat. It is used for sore throat and dry mouth and throat caused by excessive heat in the lung and stomach; acute tonsillitis sees the above syndromes. [0003] The current standard preparation method of Banlangen Granules in the National Pharmacopoeia is: decoct Banlangen twice, the first time for 2 hours, the second time for 1 hour, filter the decoction, combine the filtrates, concentrate to a relative density of 1.2 (50°C), and then Add ethanol to make the alcohol content reach 60%, let it stand for precipitation, take the supernatant, recover the ethanol and concentrate to an appropriate amount, add appropriate amount of auxiliary materials (dextrin or sucrose powder and dext...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/195A61K36/315A61K9/16A61K47/36A61P11/04
CPCA61K9/1652A61K36/195A61K36/315A61K2236/17A61K2236/19
Inventor 程玉柱夏运喜刘晓燕
Owner ANHUI YONSENT PHARMA